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| Botto,Adrian E. Cambindo; Muñoz,Juan C.; Giono,Luciana E.; Nieto-Moreno,Nicolás; Cuenca,Carmen; Kornblihtt,Alberto R.; Muñoz,Manuel J.. |
| Abstract Splicing, the process that catalyzes intron removal and flanking exon ligation, can occur in different ways (alternative splicing) in immature RNAs transcribed from a single gene. In order to adapt to a particular context, cells modulate not only the quantity but also the quality (alternative isoforms) of their transcriptome. Since 95% of the human coding genome is subjected to alternative splicing regulation, it is expected that many cellular pathways are modulated by alternative splicing, as is the case for the DNA damage response. Moreover, recent evidence demonstrates that upon a genotoxic insult, classical DNA damage response kinases such as ATM, ATR and DNA-PK orchestrate the gene expression response therefore modulating alternative splicing... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: DNA damage; Alternative splicing; ATR; ATM; DNA-PK. |
| Ano: 2020 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572020000200310 |
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| Baillieul, Marion. |
| The development of middle-infrared (MIR) sensors for organic pollutants monitoring in the aquatic environment is currently a challenge of great importance. The mid-infrared sensor based on evanescent wave spectroscopy is a promising analytical tool for simultaneous detection and quantification of a variety of pollutants such as hydrocarbon compounds. Chalcogenide glasses are particularly well adapted for sensing applications due to their wide domain of transparence (up to 10-16 µm depending on their composition). The aims of this study are to synthetize chalcogenide thin films for developing mid-infrared optical integrated platforms and perform their functionalization with polymers in order to increase the sensor sensitivity. Among (GeSe2)100-x(Sb2Se3)x... |
| Tipo: Text |
Palavras-chave: Capteur optique; Moyen infrarouge; Verres de chalcogénures; ATR; BTEX; SEIRA; Optical sensing; Mid-infrared; Chalcogenide glasses; ATR; BTEX; SEIRA. |
| Ano: 2018 |
URL: https://archimer.ifremer.fr/doc/00499/61020/64422.pdf |
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