Data/hora: 04/06/2024 13:20:10

Provedor de dados: 	19	
País: 	Japan	
Título: 	Characterization of a novel thrombospondin-related protein in Toxoplasma gondii	
Autores: 	Kawase, Osamu; Nishikawa, Yoshifumi; Bannai, Hiroshi; Matsuo, Tomohide; Xuan, Xuenan.	
Data: 	2010-06	
Ano: 	2010	
Palavras-chave: 	Ca2+-dependent secretion; Microneme protein; Secreted protein with an alteredthrombospondin repeat; Toxoplasma gondii.	
Resumo: 	Toxoplasma gondii is an obligate intracellular protozoan parasite that invades a wide range of host cells. Upon encountering host cells, the parasite releases a large variety of proteins from secretory organelles, such as micronemes, rhoptries and dense granules. The secretion of microneme protein is essential for parasite invasion. We found that a secreted protein with an altered thrombospondin repeat of Toxoplasma gondii (TgSPATR) was a novel microneme protein, which was different from known microneme proteins that carry thrombospondin repeat domains. TgSPATR was secreted in response to an intra-parasitic elevation of Ca2+ and probably secreted during early stages of parasite invasion. Thus, we suggested that TgSPATR, new member of microneme secretory protein, had a possible function in the invasion.	
Idioma: 	Inglês	
Identificador: 	http://ir.obihiro.ac.jp/dspace/handle/10322/2819	
Editor: 	Elsevier	
Formato: 	application/pdf	
Fonte: 	Elsevier Ireland Ltd