Data/hora: 13/06/2024 03:41:32

Provedor de dados: | 3
País: | Brazil
Título: | Exercise protects rat testis from cyclophosphamide-induced damage - doi: 10.4025/actascibiolsci.v35i1.12475
Autores: | Ramos, Solange de Paula; Universidade Estadual de Londrina; Goessler, Karla Fabiana; Universidade Estadual de Londrina; Ruiz, Roberto Jose; Universidade Estadual de Londrina; Ferrari, Osny; Universidade Estadual de Londrina; Polito, Marcos Doederlein; Universidade Estadual de Londrina; Salles, Maria José Sparça; Universidade Estadual de Londrina.
Data: | 2012-12-18
Ano: | 2012
Palavras-chave: | 2.06.03.00-2 cyclophosphamide; Exercise; Reproductive tract Histologia.
Resumo: | To investigate the effect of chronic moderate exercise on male reproductive tract of Wistar rats submitted to a single dose of cyclophosphamide (CP). Animals were submitted to swimming exercise during 21 days or maintained at sedentary state. Trained (TCP) and sedentary (SCP) groups received a single dose of CP (200 mg kg-1, i.p.). Trained (TCo) and sedentary (SCo) control animals received sterile PBS. Animals were killed after one week and testis, epidydimis and seminal vesicle contend were weighted. Testis were embebbed in parafim and stained with hemotaxilin and eosin. Fifty seminiferous tubules of each animal were analyzed by Johnsen score. Mean Sertoli cells counts per tubule and Leydig cells counts per area were evaluated. CP treatment impairs body weight gain in trained and sedentary animals. Liver and seminal vesicle contend were reduced only in SCo group. SCP animals presented decreased Johnsen scores, indicating a slight toxicity over germinative cells, whereas trained (TCo and TCP) animals presented increased Johnsen scores. Training increased Sertoli cell counts and prevented their loss in TCP group. Leydig cells counts were increased in trained animals, but decreased in CP treated ones (TCP). We conclude that exercise have some protective effect on male reproductive tract submitted to a single dose of CP.
Tipo: | Estudos morfológicos
Idioma: | Inglês

Identificador:

http://periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/12475

10.4025/actascibiolsci.v35i1.12475

Editor: | Universidade Estadual De Maringá

Formato:

application/pdf

application/pdf

Fonte:

Acta Scientiarum. Biological Sciences; v. 35, n. 1 (2013); 105-113

Acta Scientiarum. Biological Sciences; v. 35, n. 1 (2013); 105-113

Fonte:

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DECLARAÇÃO DE ORIGINALIDADE E CESSÃO DE DIREITOS AUTORAIS  Declaro que o presente artigo é original, não tendo sido submetido à publicação em qualquer outro periódico nacional ou internacional, quer seja em parte ou em sua totalidade. Declaro, ainda, que uma vez publicado na revista Acta Scientiarum. Biological Sciences, editada pela Universidade Estadual de Maringá, o mesmo jamais será submetido por mim ou por qualquer um dos demais co-autores a qualquer outro meio de divulgação científica. Através deste instrumento, em meu nome e em nome dos demais co-autores, porventura existentes, cedo os direitos autorais do referido artigo à Universidade Estadual de Maringá e declaro estar ciente de que a não observância deste compromisso submeterá o infrator a sanções e penas previstas na Lei de Proteção de Direitos Autorias (Nº9609, de 19/02/98).