Data/hora: 13/06/2024 02:28:49

Provedor de dados: | 3
País: | Brazil
Título: | Venom of the giant ant Dinoponera quadriceps attenuates inflammatory pain in mouse cutaneous wound healing model
Autores: | Assreuy, Ana Maria Sampaio; Adjafre, Beatriz Lima; Sousa, Évilla Rayanne Oliveira; Alves, Ana Paula Negreiros Nunes; Pires, Alana de Freitas; Quinet, Yves; Mota, Mário Rogério Lima.
Data: | 2020-02-07
Ano: | 2020
Palavras-chave: | DqV; Hypernociception; Leukocyte infiltrate; Scar.
Resumo: | Arthropod venoms are potential sources of bioactive substances, providing tools for the validation of popular use and new drugs design. Ants belonging to the genus Dinoponera are used in the folk medicine to treat inflammatory conditions. It was previously demonstrated that the venom of the giant ant Dinoponera quadriceps (DqV), containing a mixture of polypeptides, elicit antinociceptive effect in mice models of chemical, mechanical and thermal nociception. The aim of this study was to evaluate DqV antiinflammatory and antihypernociceptive effects in a mice model of traumatic cutaneous wound. Colonies of D. quadriceps were collected in the ‘‘Serra de Maranguape’’ (State of Ceará, northeastern Brazil), a small mountain range located on the coastal zone, and the venom secreted by the ant glands was extracted with capillary tubes, further lyophilized and maintained at -20 ± 1ºC until use. Wounds were performed in the dorsum of Swiss mice. Animals received intravenous (i.v.) injection of DqV (50 µg -1kg day-1) during 3 days for evaluation of inflammatory parameters present in the wounds: hypernociception, leukocyte infiltrate, myeloperoxidase activity, nitrite nitrate-1 content. Data was tested by two-way ANOVA and Bonferroni’s post-hoc test. DqV reduced (2.7 folds) hypernociception at 48 hours, leukocyte infiltration by 65% at 6 hours and myeloperoxidase activity by 60% at 0.5 hour after wound induction. In conclusion, the venom extracted from D. quadriceps glands attenuates inflammation and hypernociception in mice cutaneous wounds.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês

Identificador:

http://periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/47680

10.4025/actascibiolsci.v42i1.47680

Editor: | Universidade Estadual De Maringá
Relação: | http://periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/47680/751375149339
Formato: | application/pdf

Fonte:

Acta Scientiarum. Biological Sciences; Vol 42 (2020): Publicação contínua; e47680

Acta Scientiarum. Biological Sciences; v. 42 (2020): Publicação contínua; e47680

1807-863X

1679-9283

Fonte:

Copyright (c) 2020 Acta Scientiarum. Biological Sciences

https://creativecommons.org/licenses/by/4.0