Data/hora: 13/06/2024 17:15:46

Provedor de dados: | 3
País: | Brazil

Título:

In vitro activity of 2-pyridinecarboxylic acid against trypanosomes of the subgenus Schizotrypanum isolated from the bat Phyllostomus hastatus - doi: 10.4025/actascibiolsci.v33i4.6482

In vitro activity of 2-pyridinecarboxylic acid against trypanosomes of the subgenus Schizotrypanum isolated from the bat Phyllostomus hastatus - doi: 10.4025/actascibiolsci.v33i4.6482

Autores: | Corrêa, Paulo Roberto Ceridório; UEL; Pinto, Artur da Silveira; UFMG; Silva, Grácia Divina de Fátima; UFMG; Vieira Filho, Sidney Augusto; UFOP; Duarte, Lucienir Pains; UFMG; Yamada-Ogatta, Sueli Fumie; UEL.
Data: | 2011-09-02
Ano: | 2011
Palavras-chave: | Ciências Biológicas; Microbiologia; 2.12.02.00-1 bat trypanosome; Schizotrypanum; 2-pyridinecarboxylic acid; Antimicrobial activity Atividade antimicrobiana bat trypanosome; Schizotrypanum; 2-pyridinecarboxylic acid; Antimicrobial activity.
Resumo: | The effect of 2-pyridinecarboxylic acid (picolinic acid) on trypanosomes of the subgenus Schizotrypanum isolated from the bat Phyllostomus hastatus was determined in this study. Picolinic acid, at 50 &amp;micro;g mL-1, inhibited epimastigote growth by 99% after 12 days incubation. In addition, trypomastigote motility decreased by 50% after 6h and completely after 24h in the presence of 50 &amp;micro;g mL-1 picolinic acid. The 50% cytotoxic concentration on HEp-2 cell line was 275 &amp;micro;g mL-1 after 4 days incubation. Altogether, these results indicate higher toxicity against trypanosomes. The inhibitory effect of picolinic acid on epimastigote growth can be partially reversed by nicotinic acid and L-tryptophan, suggesting a competitive inhibition. Furthermore, two anti-Trypanosoma (Schizotrypanum) cruzi drugs were also evaluated with regard to bat trypanosome growth. Benznidazole, at 50 &amp;micro;g mL-1, inhibited epimastigote growth by 90% after 12 days incubation. Nifurtimox, at the same concentration, caused 96% growth inhibition after four days incubation. Corroborating a previous study, bat trypanosomes are a good model for screening new trypanocidal compounds. Moreover, they can be used to study many biological processes common to human pathogenic trypanosomatids.
Idioma: | Inglês

Identificador:

http://periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/6482

10.4025/actascibiolsci.v33i4.6482

Editor: | Universidade Estadual De Maringá

Formato:

application/pdf

application/pdf

Fonte:

Acta Scientiarum. Biological Sciences; v. 33, n. 4 (2011); 437-443

Acta Scientiarum. Biological Sciences; v. 33, n. 4 (2011); 437-443

Fonte:

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DECLARAÇÃO DE ORIGINALIDADE E CESSÃO DE DIREITOS AUTORAIS  Declaro que o presente artigo é original, não tendo sido submetido à publicação em qualquer outro periódico nacional ou internacional, quer seja em parte ou em sua totalidade. Declaro, ainda, que uma vez publicado na revista Acta Scientiarum. Biological Sciences, editada pela Universidade Estadual de Maringá, o mesmo jamais será submetido por mim ou por qualquer um dos demais co-autores a qualquer outro meio de divulgação científica. Através deste instrumento, em meu nome e em nome dos demais co-autores, porventura existentes, cedo os direitos autorais do referido artigo à Universidade Estadual de Maringá e declaro estar ciente de que a não observância deste compromisso submeterá o infrator a sanções e penas previstas na Lei de Proteção de Direitos Autorias (Nº9609, de 19/02/98).