Data/hora: 13/06/2024 05:27:46

Provedor de dados: | 3
País: | Brazil
Título: | The sleep-wakefulness cycle of Wistar rats with spontaneous absence-like epilepsy
Autores: | André, Edison Sanfelice; Bruno-Neto, Rafael; Valle, Angela Cristina do; Timo-Iaria, César.
Data: | 2015-07-01
Ano: | 2015
Palavras-chave: | 2.07.02.01-9 epilepsy; Absence seizures; Spike-wave; Sleep; Wakefulness; Rats Neurofisiologia.
Resumo: | Possible interactions between the sleep-wakefulness cycle and a new kind of spontaneous epilepsy, expressed as absence-like seizures and spike-wave bursts in FMUSP rats, are evaluated. The electro-oscillograms of some cortical and subcortical regions of the brain were recorded, as well as head, rostrum/vibrissae and eye movements. Recordings were performed uninterruptedly during 24 hours. The seizures were mostly concentrated in the wakefulness state but they could occur in any other phase, including paradoxical sleep. After the seizure, the rats usually returned to the same phase that was interrupted, although they often returned to wakefulness. There was an intense fragmentation of the sleep-wakefulness cycle. The incidence of each cycle phase was significantly reduced, except SIII of synchronized sleep and paradoxical sleep, thus maintaining the overall duration and architecture of the sleep-wakefulness cycle. The fragmentation of the cycle seems to be due to an impairment of the very processes that generate sleep and wakefulness. Electrophysiological and behavioral profiles of the FMUSP rats recommend accurate and comprehensive study of the animal model owing to its resemblance to seizures in humans and also to discrepancies with existing genetic or experimental epilepsy models.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês

Identificador:

http://periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/26908

10.4025/actascibiolsci.v37i3.26908

Editor: | Universidade Estadual De Maringá
Relação: | http://periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/26908/pdf_75
Formato: | application/pdf

Fonte:

Acta Scientiarum. Biological Sciences; v. 37, n. 3 (2015); 367-376

Acta Scientiarum. Biological Sciences; v. 37, n. 3 (2015); 367-376

1807-863X

1679-9283