Data/hora: 05/06/2024 18:49:34

Provedor de dados: | 52
País: | Brazil
Título: | Mimosine and cyclophosphamide: a potential new combination therapy used to prevent tumor development
Autores: | Dipe,Vânius Vinícius; Gotardo,André Tadeu; Haraguchi,Mitsue; Górniak,Silvana Lima.
Data: | 2012-12-01
Ano: | 2012
Palavras-chave: | Leucaena leucocephala; Mimosine; Ehrlich tumor; Cyclophosphamide; Anticancer activity.
Resumo: | The effects of mimosine (MI), which is an amino acid that is derived from Leucaena leucocephala, were evaluated on the growth of ascitic Ehrlich tumors, and the effects of the combination treatment of MI and cyclophosphamide (CY) on tumor growth were also assessed. Mice were divided into groups that received the following treatments over the course of 20 days: phosphate buffer solution (CO), MI, Ehrlich cells (E), E plus CY (EC), E plus MI (EM) and E plus MI and CY (EMC). No signs of toxicity were detected in the mice from the MI group. The mice from the EMC group showed reductions in body weights when compared with those from the E group. The animals from the EC, EM and EMC groups showed reductions in ascitic volume compared with those from the E group. The mice from the EMC group showed reductions in total cell numbers of ascitic fluid compared with those from the E, EC and EM groups. The combination of MI and CY was the most effective treatment for Ehrlich tumor ascites.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132012000600010
Editor: | Instituto de Tecnologia do Paraná - Tecpar
Relação: | 10.1590/S1516-89132012000600010
Formato: | text/html
Fonte: | Brazilian Archives of Biology and Technology  v.55 n.6 2012
Fonte: | info:eu-repo/semantics/openAccess