Data/hora: 13/06/2024 17:34:15

Provedor de dados: 	55	
País: 	Brazil	
Título: 	Cefepime versus extended spectrum β-lactamase-producing Enterobacteriaceae	
Autores: 	Nogueira,Keite da Silva; Daur,Alessandra Vale; Reason,Iara Taborda de Messias; Gales,Ana Cristina; Costa,Libera Maria Dalla.	
Data: 	2011-04-01	
Ano: 	2011	
Palavras-chave: 	Enterobacteriaceae; Beta-lactamases; Cephalosporin resistance.	
Resumo: 	The objective of this study was to evaluate the susceptibility to cefepime of a large group of ESBL- producing enterobacteria recently isolated in a Brazilian teaching hospital . The study included 280 strains of ESBL-producing enterobacteria, isolated between 2005 and 2008. The presence of the genes blaCTX-M, blaTEM and blaSHV was determined by PCR and confirmed by nucleotide sequencing. Susceptibility testing for cefepime was performed by disc-diffusion, agar dilution method and E-test®. Among the isolates, 34 (12.1%) presented a cefepime inhibition zone &amp;gt; 21 and MIC &lt; 8 mg/L by agar dilution and E-strip methods. The use of cefepime for the treatment of infections caused by ESBL-producing bacteria has been controversial. Some studies of PD/PK show the probability of achieving the required PD parameters for cefepime, when the MICs were &lt; 8 mg/L, whereas others have reported therapeutic failure with the same MIC. Additional data is essential to come to terms about the report and treatment with cefepime in ESBL-producing organisms especially when these microorganisms are isolated from sterile sites and from critically ill patients.	
Tipo: 	Info:eu-repo/semantics/article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000200014	
Editor: 	Brazilian Society of Infectious Diseases	
Relação: 	10.1590/S1413-86702011000200014	
Formato: 	text/html	
Fonte: 	Brazilian Journal of Infectious Diseases  v.15 n.2 2011	
Fonte: 	info:eu-repo/semantics/openAccess