Data/hora: 11/06/2024 12:19:50

Provedor de dados: | 55
País: | Brazil
Título: | Effectiveness of highly active antiretroviral therapy (HAART) used concomitantly with rifampicin in patients with tuberculosis and AIDS
Autores: | Sant'Anna,Flávia Marinho; Velasque,Luciane; Costa,Marli Jane; Schmaltz,Carolina Arana; Morgado,Mariza Gonçalves; Lourenço,Maria Cristina; Grinsztejn,Beatriz; Rolla,Valéria Cavalcanti.
Data: | 2009-10-01
Ano: | 2009
Palavras-chave: | Tuberculosis; AIDS; HAART; Rifampicin; Effectiveness.
Resumo: | This study evaluated the effectiveness of two HAART regimens concomitant to rifampicin based tuberculosis (TB) treatment. Patients with TB/HIV diagnosis followed at the TB program between June 2000 and March 2005 were prospectively evaluated. The different HAART regimens in antiretrovirals (ARV) treatment naïve and ARV experienced patients were compared. The effectiveness of HAART was defined as a VL &lt;80 copies/mL from month 4 to month 10 after TB treatment. One hundred and forty-two patients were included. Among these, 68 (47%) were treatment naïve and 76 (53%) previously exposed. Odds ratio (OR) in naïve patients treated with efavirenz (EFV) based regimen (n=42) compared to ritonavir/saquinavir (RTV/SQV) based regimen (n=26) was 8.0 (CI=1.67-38.35, p=0.008). OR from ARV experienced patients treated with RTV/SQV based regimen compared to EFV was 3.08 (CI=0.65-14.6, p=0.15), although with no statistical significance. Better effectiveness and tolerability were observed in antiretrovirals treatment naïve patients using EFV based regimens. Although not statistically significant, a favorable virologic response and a better tolerability were observed in the ARV experienced patients group who received a RTV/SQV based regimen.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000500010
Editor: | Brazilian Society of Infectious Diseases
Relação: | 10.1590/S1413-86702009000500010
Formato: | text/html
Fonte: | Brazilian Journal of Infectious Diseases  v.13 n.5 2009
Fonte: | info:eu-repo/semantics/openAccess