Data/hora: 10/06/2024 06:43:58

Provedor de dados: | 55
País: | Brazil
Título: | A comparative study of single-dose treatment of chancroid using thiamphenicol versus Azithromycin
Autores: | B. Junior,Walter; Di Chiacchio,Nilton G.; Di Chiacchio,Nilton; Romiti,Ricardo; Criado,Paulo R.; Velho,Paulo Eduardo N. Ferreira.
Data: | 2009-06-01
Ano: | 2009
Palavras-chave: | Azithromycin; Chancroid; Haemophilus ducreyi; Single dose; Thiamphenicol.
Resumo: | A study was conducted in São Paulo, Brazil, to compare azithromycin with thiamphenicol for the single-dose treatment of chancroid. In all, 54 men with chancroid were tested. The etiology was determined by clinical characterization and direct bacterioscopy with Gram staining. None of the patients had positive serology or dark-field examination indicating active infection with Treponema pallidum. Genital infections due to Neisseria gonorrhoeae and herpes simplex virus were excluded by polymerase chain reaction testing. For 54 patients with chancroid, cure rates with single-dose treatment were 73% with azithromycin and 89% with thiamphenicol. HIV seropositivity was found to be associated with treatment failure (p=0.001). The treatment failed in all HIV positive patients treated with azithromycin (p=0.002) and this drug should be avoided in these co-infected patients. In the view of the authors, thiamphenicol is the most indicated single-dose regimen for chancroid treatment.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000300012
Editor: | Brazilian Society of Infectious Diseases
Relação: | 10.1590/S1413-86702009000300012
Formato: | text/html
Fonte: | Brazilian Journal of Infectious Diseases  v.13 n.3 2009
Fonte: | info:eu-repo/semantics/openAccess