Data/hora: 10/06/2024 17:08:51

Provedor de dados: | 56
País: | Brazil
Título: | Human papillomavirus detection and p16 methylation pattern in a case of esophageal papilloma
Autores: | Afonso,L.A.; Moysés,N.; Cavalcanti,S.M.B.
Data: | 2010-07-01
Ano: | 2010
Palavras-chave: | Human papillomavirus; Esophageal cancer; Restriction fragment length polymorphism.
Resumo: | Esophageal cancer is a prevalent cancer worldwide. Some studies have reported the possible etiology of human papillomavirus (HPV) in benign and malignant papillomas of the esophagus but the conclusions are controversial. In the present study, we investigated an esophageal papilloma from a 30-year-old male patient presenting aphasia. HPV DNA was detected by generic PCR using MY09/11 primers, and restriction fragment length polymorphism revealed the presence of HPV54, usually associated with benign genital lesions. Hypermethylation of the pINK4A gene was also investigated due to its relation to malignant transformation, but no modification was detected in the host gene. Except for an incipient reflux, no risk factors such as cigarette smoking, alcohol abuse or an infected sexual partner were recorded. Since esophageal lesions may have a malignant potential, HPV detection and typing are useful tools for patient follow-up.
Tipo: | Info:eu-repo/semantics/report
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2010000700013
Editor: | Associação Brasileira de Divulgação Científica
Relação: | 10.1590/S0100-879X2010007500055
Formato: | text/html
Fonte: | Brazilian Journal of Medical and Biological Research  v.43 n.7 2010
Fonte: | info:eu-repo/semantics/openAccess