Data/hora: 05/06/2024 16:39:46

Provedor de dados: 	56	
País: 	Brazil	
Título: 	The role of necroptosis in neurosurgical diseases	
Autores: 	Liu,T.; Bao,Y.H.; Wang,Y.; Jiang,J.Y.	
Data: 	2015-04-01	
Ano: 	2015	
Palavras-chave: 	Molecular mechanism; Pathogenesis; Programmed cell death; Therapy.	
Resumo: 	Programmed necrosis or necroptosis is an alternative form of cell death that is executed through a caspase-independent pathway. Necroptosis has been implicated in many pathological conditions. Genetic or pharmacological inhibition of necroptotic signaling has been shown to confer neuroprotection after traumatic and ischemic brain injury. Therefore, the necroptotic pathway represents a potential target for neurological diseases that are managed by neurosurgeons. In this review, we summarize recent advances in the understanding of necroptotic signaling pathways and explore the role of necroptotic cell death in craniocerebral trauma, brain tumors, and cerebrovascular diseases.	
Tipo: 	Info:eu-repo/semantics/article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2015000400292	
Editor: 	Associação Brasileira de Divulgação Científica	
Relação: 	10.1590/1414-431x20144310	
Formato: 	text/html	
Fonte: 	Brazilian Journal of Medical and Biological Research  v.48 n.4 2015	
Fonte: 	info:eu-repo/semantics/openAccess