Data/hora: 10/06/2024 18:10:39

Provedor de dados: | 56
País: | Brazil
Título: | Effects of simvastatin/ezetimibe on microparticles, endothelial progenitor cells and platelet aggregation in subjects with coronary heart disease under antiplatelet therapy
Autores: | Camargo,L.M.; França,C.N.; Izar,M.C.; Bianco,H.T.; Lins,L.S.; Barbosa,S.P.; Pinheiro,L.F.; Fonseca,F.A.H.
Data: | 2014-05-01
Ano: | 2014
Palavras-chave: | Endothelial microparticles; Platelet microparticles; Platelet aggregation; Endothelial progenitor cells; Simvastatin/ezetimibe.
Resumo: | It is not known whether the addition of ezetimibe to statins adds cardiovascular protection beyond the expected changes in lipid levels. Subjects with coronary heart disease were treated with four consecutive 1-week courses of therapy (T) and evaluations. The courses were: T1, 100 mg aspirin alone; T2, 100 mg aspirin and 40 mg simvastatin/10 mg ezetimibe; T3, 40 mg simvastatin/10 mg ezetimibe, and 75 mg clopidogrel (300 mg initial loading dose); T4, 75 mg clopidogrel alone. Platelet aggregation was examined in whole blood. Endothelial microparticles (CD51), platelet microparticles (CD42/CD31), and endothelial progenitor cells (CD34/CD133; CDKDR/CD133, or CD34/KDR) were quantified by flow cytometry. Endothelial function was examined by flow-mediated dilation. Comparisons between therapies revealed differences in lipids (T2 and T3&lt;T1 and T4 for total cholesterol, LDL-C, and triglycerides; P&lt;0.002 for all), as well as for endothelial function (T2&gt;T1 and T4, P=0.001). Decreased platelet aggregation was observed after aspirin (arachidonic acid, T1&lt;T3 and T4, P=0.034) and clopidogrel (adenosine, T3 and T4&lt;T1 and T2, P&lt;0.0001) therapy. Simvastatin/ezetimibe diphosphate did not change platelet aggregation, the amount of circulating endothelial and platelet microparticles, or endothelial progenitor cells. Cardiovascular protection following therapy with simvastatin/ezetimibe seems restricted to lipid changes and improvement of endothelial function not affecting the release of microparticles, mobilization of endothelial progenitor cells or decreased platelet aggregation.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2014000500432
Editor: | Associação Brasileira de Divulgação Científica
Relação: | 10.1590/1414-431X20143628
Formato: | text/html
Fonte: | Brazilian Journal of Medical and Biological Research  v.47 n.5 2014
Fonte: | info:eu-repo/semantics/openAccess