Data/hora: 10/06/2024 15:22:31

Provedor de dados: | 56
País: | Brazil
Título: | Association between MCP-1 -2518A&amp;gt;G polymorphism and asthma susceptibility: a meta-analysis
Autores: | Chen,Wenli; Cui,Jiewei; Xiang,Guoan; Zhang,Jianpeng; Gao,Hongmei.
Data: | 2019-01-01
Ano: | 2019
Palavras-chave: | MCP-1; Polymorphism; Asthma; Susceptibility; Meta-analysis.
Resumo: | The published data on the association between MCP-1 -2518A&gt;G polymorphism and asthma susceptibility are inconclusive. Therefore, we performed a meta-analysis to estimate the impact of MCP-1 -2518A&gt;G polymorphism on asthma susceptibility. PubMed, Web of Science, Wanfang, and China National Knowledge Infrastructure (CNKI) databases were used to identify eligible studies. The pooled odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were used to calculate the strength of association. Sensitivity analysis was performed to evaluate the influence of individual studies on the estimates of overall effect, and funnel plots and Egger's test were used to assess publication bias. Eight publications with 1562 asthma patients and 1574 controls were finally identified. Overall, we found no significant association between MCP-1 -2518A&gt;G polymorphism and asthma susceptibility in any of the genetic model comparisons. After stratified analysis by ethnicity, the results showed that a significant association with asthma risk was found in Caucasians in all the genetic models. However, a protective association was found in Africans under the dominant model. The present meta-analysis suggested that the MCP-1 -2518 A&gt;G polymorphism is a risk factor for asthma in the Caucasian population, nevertheless it has a protective effect in the African population.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2019001100602
Editor: | Associação Brasileira de Divulgação Científica
Relação: | 10.1590/1414-431x20198549
Formato: | text/html
Fonte: | Brazilian Journal of Medical and Biological Research  v.52 n.11 2019
Fonte: | info:eu-repo/semantics/openAccess