Data/hora: 05/06/2024 11:41:28

Provedor de dados: 	56	
País: 	Brazil	
Título: 	Toxicity to sea urchin egg development of the quinone fraction obtained from Auxemma oncocalyx	
Autores: 	Costa-Lotufo,L.V.; Ferreira,M.A.D.; Lemos,T.L.G.; Pessoa,O.D.L.; Viana,G.S.B.; Cunha,G.M.A.	
Data: 	2002-08-01	
Ano: 	2002	
Palavras-chave: 	Auxemma oncocalyx; Quinones; Sea urchin eggs; Oncocalyxone A.	
Resumo: 	Auxemma oncocalyx Taub. belongs to the Boraginaceae family and is native to the Brazilian northeast where it is known as "pau-branco". We investigated the ability of the water soluble fraction isolated from the heartwood of A. oncocalyx to inhibit sea urchin egg development. This fraction contains about 80% oncocalyxone A (quinone fraction), a compound known to possess strong cytotoxic and antitumor activities. In fact, the quinone fraction inhibited cleavage in a dose-dependent manner [IC50 of 18.4 (12.4-27.2) µg/ml, N = 6], and destroyed the embryos in the blastula stage [IC50 of 16.2 (13.7-19.2) µg/ml, N = 6]. We suggest that this activity is due to the presence of oncocalyxone A. In fact, these quinones present in A. oncocalyx extract have strong toxicity related to their antimitotic activity.	
Tipo: 	Info:eu-repo/semantics/other	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2002000800010	
Editor: 	Associação Brasileira de Divulgação Científica	
Relação: 	10.1590/S0100-879X2002000800010	
Formato: 	text/html	
Fonte: 	Brazilian Journal of Medical and Biological Research  v.35 n.8 2002	
Fonte: 	info:eu-repo/semantics/openAccess