Data/hora: 10/06/2024 18:10:11

Provedor de dados: | 60
País: | Brazil
Título: | Antiplatelet activity of white and pink Nelumbo nucifera Gaertn flowers
Autores: | Durairaj,Brindha; Dorai,Arthi.
Data: | 2010-09-01
Ano: | 2010
Palavras-chave: | Nelumbo nucifera Gaertn/phytochemical constituents; Nelumbo nucifera Gaertn/pharmacognosy; Nelumbo nucifera Gaertn/Antiplatelet activity; Ayurvedic medicine; Natural products; Aspirin.
Resumo: | Nelumbo nucifera Gaertn (Nelumbonaceae) a plant used in Ayurvedic medicine (common name: lotus), is a perennial, large and rhizomatous aquatic herb most prevalent in South India. Preliminary phytochemical screening of both white and pink Nelumbo nucifera flowers revealed the presence of phytochemical constituents (flavonoids, alkaloids, phenols etc,). Hence, an attempt has been made to screen the effect of Nelumbo nucifera flowers (both types) on platelet aggregation. The antiplatelet activity of hydroethanolic extract of both types of flowers was studied using platelet-rich plasma in different concentrations (100-500µg/ml). Both white and pink Nelumbo nucifera flower extracts showed dose-dependent effective antiplatelet activity with maximum activity at 500µg/ml concentration; prevention of platelet aggregation was 50% of that achieved with standard aspirin. Furthermore, the antiplatelet activity of white flowers was relatively high (p&lt;0.05; ANOVA) compared to pink flowers. In conclusion, these observations suggest that both varieties of Nelumbo nucifera flower extracts exert different levels of inhibitory action on platelets in vitro (secretion and platelet aggregation suppression) due to differences in phytochemical content (alkaloids, flavonoids, phenols, tannins, phytosteroids, glycosides and saponins).
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502010000300023
Editor: | Universidade de São Paulo, Faculdade de Ciências Farmacêuticas
Relação: | 10.1590/S1984-82502010000300023
Formato: | text/html
Fonte: | Brazilian Journal of Pharmaceutical Sciences  v.46 n.3 2010
Fonte: | info:eu-repo/semantics/openAccess