Data/hora: 10/06/2024 15:19:21

Provedor de dados: | 80
País: | Brazil
Título: | Experimental Lachesis muta rhombeata envenomation and effects of soursop (Annona muricata) as natural antivenom
Autores: | Cremonez,Caroline Marroni; Leite,Flávia Pine; Bordon,Karla de Castro Figueiredo; Cerni,Felipe Augusto; Cardoso,lara Aimê; Gregório,Zita Maria de Oliveira; Souza,Rodrigo Cançado Gonçalves de; Souza,Ana Maria de; Arantes,Eliane Candiani.
Data: | 2016-01-01
Ano: | 2016
Palavras-chave: | Lachesis muta rhombeata; Bushmaster; Natural antivenom; Antiophidic action; Soursop; Annona muricata L.
Resumo: | Abstract  Background  In the Atlantic forest of the North and Northeast regions of Brazil, local population often uses the fruit juice and the aqueous extract of leaves of soursop (Annona muricata L.) to treat Lachesis muta rhombeata envenomation. Envenomation is a relevant health issue in these areas, especially due to its severity and because the production and distribution of antivenom is limited in these regions. The aim of the present study was to evaluate the relevance of the use of soursop leaf extract and its juice against envenomation by Lachesis muta rhombeata.  Methods  We evaluated the biochemical, hematological and hemostatic parameters, the blood pressure, the inflammation process and the lethality induced by Lachesis muta rhombeata snake venom. We also assessed the action of the aqueous extract of leaves (AmL) and juice (AmJ) from A. muricata on the animal organism injected with L. m. rhombeata venom (LmrV) in the laboratory environment.  Results  LmrV induced a decrease of total protein, albumin and glucose; and increase of creatine kinase, aspartate aminotransferase, and urea concentrations. It provoked hemoconcentration followed by reduction of hematocrit, an increase in prothrombin time and partial thromboplastin time and a decrease of the blood pressure. LmrV induced the release of interleukin-6, an increase in neutrophils and changes in the serum protein profile, characteristic of the acute inflammatory process. LD50 values were similar for the groups injected with LmrV and treated or untreated with AmJ and AmL. Both treatments play a role on the maintenance of blood glucose, urea and coagulation parameters and exert a protective action against the myotoxicity. However, they seem to worsen the hypotension caused by LmrV.  Conclusion  The treatments with AmJ and AmL present some beneficial actions, but they might intensify some effects of the venom. Therefore, additional studies on A. muricata are necessary to enable its use as natural antivenom for bushmaster snakebite.
Tipo: | Info:eu-repo/semantics/article
Idioma: | Inglês
Identificador: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992016000100310
Editor: | Centro de Estudos de Venenos e Animais Peçonhentos
Relação: | 10.1186/S40409-016-0067-6
Formato: | text/html
Fonte: | Journal of Venomous Animals and Toxins including Tropical Diseases  v.22 2016
Fonte: | info:eu-repo/semantics/openAccess