Data/hora: 13/06/2024 04:19:00

Provedor de dados: 	80	
País: 	Brazil	
Título: 	Comparative analysis of the venom proteome of four important Malaysian snake species	
Autores: 	Vejayan,Jaya; Khoon,Too Lay; Ibrahim,Halijah.	
Data: 	2014-01-01	
Ano: 	2014	
Palavras-chave: 	Mass spectrometry; Snake venoms; Proteomics; Two-dimensional gel electrophoresis.	
Resumo: 	BackgroundNaja kaouthia, Ophiophagus hannah, Bungarus fasciatusandCalloselasma rhodostomaare four venomous snakes indigenous to Malaysia. In the present study, their proteomic profile by two-dimensional gel electrophoresis (2-DE) have been separated and compared.ResultsThe 2-DE of venoms of the four species snake demonstrated complexity and obvious interspecies differences in proteome profiles. A total of 63 proteins were identified in the four species: C. rhodostoma -26, N. kaouthia -16, O. hannah -15 and B. fasciatus -6.ConclusionsDespite the identifications of major proteins in the four snake species, a large number of protein spots from the 2-DE were unidentified even though the spots displayed high-quality MALDI-TOF-MS spectra. Those identified included phospholipase A2 proteins in all four venoms, long neurotoxins in both cobra species and the C. rhodostomavenom found with the most varied types of peptidases, i.e. metalloproteinase kistomin, halystase and L-amino acid oxidase.	
Tipo: 	Info:eu-repo/semantics/article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992014000200317	
Editor: 	Centro de Estudos de Venenos e Animais Peçonhentos	
Relação: 	10.1186/1678-9199-20-6	
Formato: 	text/html	
Fonte: 	Journal of Venomous Animals and Toxins including Tropical Diseases  v.20 2014	
Fonte: 	info:eu-repo/semantics/openAccess