Home Itens selecionados Provedores de dados OAI Créditos Sobre Ajuda

			Busca avançada
	Provedor de dados AgEcon (4.056) Infoteca-e (2.202) Organic Eprints (1.331) Buscador Latinoamericano (792) ArchiMer (631) Nature Precedings (617) Buscador Latinoamericano (574) Ciência Rural (458) R. Bras. Zootec. (334) Naturalis (321) Rev. Bras. Ciênc. Solo (287) Ciência e Agrotecnologia (276) Arq. Bras. Med. Vet. Zootec. (244) PAB (240) OceanDocs (230) Colegio de Postgraduados (226) OAK (224) eCrystals (213) Rev. Bras. Frutic. (211) BABT (189) Mais... Autor Hursthouse, Michael B. (211) Callear, Samantha K. (106) Threlfall, Terry L. (55) Coles, Simon J. (41) Coles (née Huth), Susanne L. (29) CARVALHO, H. W. L. de (28) Koese, B. (27) Huth, Susanne L. (26) CARDOSO, M. J. (24) CUNHA, G. R. da (24) FEITOSA, L. F. (20) LOPES, A. de M. (20) PACHECO, C. A. P. (20) BELTRÃO, N. E. de M. (19) Benfield, Mark (19) Detmann,Edenio (19) MELO, K. E. de O. (19) OLIVEIRA, I. R. de (19) Silva,A.A. (19) Tisdell, Clement A. (19) Mais... Palavra-chave Agricultural and Food Policy (701) Agribusiness (625) Crop Production/Industries (502) International Relations/Trade (465) Resource /Energy Economics and Policy (448) Environmental Economics and Policy (439) Food Consumption/Nutrition/Food Safety (427) Farm Management (403) Livestock Production/Industries (378) Community/Rural/Urban Development (330) Research Methods/ Statistical Methods (296) Marketing (287) Demand and Price Analysis (281) Food Security and Poverty (246) Research and Development/Tech Change/Emerging Technologies (242) Quality (236) ECUADOR (224) Land Economics/Use (220) Agricultural Finance (218) Organic (193) Mais... Tipo do documento Info:eu-repo/semantics/article (5.063) Conference Paper or Presentation (2.247) Text (1.409) Journal Article (758) Conference paper, poster, etc. (685) Journal article (586) Manuscript (518) Working or Discussion Paper (476) Documentos (INFOTECA-E) (449) Fôlder / Folheto / Cartilha (INFOTECA-E) (415) Tesis (397) Report (389) Comunicado Técnico (INFOTECA-E) (341) Artículo (286) Journal Contribution (266) Artigo de divulgação na mídia (INFOTECA-E) (261) Journal paper (246) Crystal Structure Data Holding (213) Article / Letter to the editor (202) Boletim de Pesquisa e Desenvolvimento (INFOTECA-E) (202) Mais... Ano 2008 (18.055) País Brazil (7.176) United States (4.056) Ecuador (1.366) Germany (1.331) United Kingdom (957) France (631) Chile (476) Argentina (434) Mexico (354) Netherlands (347) Belgium (230) Japan (224) Ukraine (131) Colombia (110) Cuba (110) Canada (98) Thailand (14) India (10) Mais... Idioma Inglês (6.876) Português (6.144) Espanhol (1.785) Francês (231) Japonês (183) deu (167) Russo (109) Húngaro (73) dan (59) Alemão (55) Italiano (14) Thailandês (14) fra (12) ces (10) nld (7) nor (5) swe (4) Holandês (3) ar (2) ita (2) Mais...		Registro completo Provedor de dados:  Nature Precedings País:  United Kingdom Título:  Successful use of axonal transport for drug delivery by synthetic molecular vehicles Autores:  Aaron G. Filler Garth Whiteside Mark Bacon Martyn Frederickson Franklyn A. Howe Miri K. Rabinowitz Alan J. Sokoloff Terrence Deacon Chris Abell Raj Munglani John R. Griffiths B. Anthony Bell Andrew Lever Data:  2008-08-06 Ano:  2008 Palavras-chave:  Biotechnology Chemistry Molecular Cell Biology Neuroscience Pharmacology Resumo:  We report the use of axonal transport to achieve intraneural drug delivery. We constructed a novel tripartite complex of an axonal transport facilitator conjugated to a linker molecule bearing up to a hundred reversibly attached drug molecules. The complex efficiently enters nerve terminals after intramuscular or intradermal administration and travels within axonal processes to neuron cell bodies. The tripartite agent provided 100-fold amplification of saturable neural uptake events, delivering multiple drug molecules per complex. _In vivo_, analgesic drug delivery to systemic and to non-targeted neural tissues was greatly reduced compared to existing routes of administration, thus exemplifying the possibility of specific nerve root targeting and effectively increasing the potency of the candidate drug gabapentin 300-fold relative to oral administration. Tipo:  Manuscript Identificador:  http://precedings.nature.com/documents/2164/version/1 oai:nature.com:10101/npre.2008.2164.1 http://hdl.handle.net/10101/npre.2008.2164.1 Fonte:  Nature Precedings Direitos:  Creative Commons Attribution 3.0 License Fechar

Empresa Brasileira de Pesquisa Agropecuária - Embrapa Todos os direitos reservados, conforme Lei n° 9.610 Política de Privacidade Área restrita		Embrapa Parque Estação Biológica - PqEB s/n° Brasília, DF - Brasil - CEP 70770-901 Fone: (61) 3448-4433 - Fax: (61) 3448-4890 / 3448-4891 SAC: https://www.embrapa.br/fale-conosco