| Registro completo |
| Provedor de dados: |
OAK
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| País: |
Japan
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| Título: |
Characterization of a novel thrombospondin-related protein in Toxoplasma gondii
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| Autores: |
Kawase, Osamu
Nishikawa, Yoshifumi
Bannai, Hiroshi
Matsuo, Tomohide
Xuan, Xuenan
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| Data: |
2010-06
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| Ano: |
2010
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| Palavras-chave: |
Ca2+-dependent secretion
Microneme protein
Secreted protein with an alteredthrombospondin repeat
Toxoplasma gondii
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| Resumo: |
Toxoplasma gondii is an obligate intracellular protozoan parasite that invades a wide range of host cells. Upon encountering host cells, the parasite releases a large variety of proteins from secretory organelles, such as micronemes, rhoptries and dense granules. The secretion of microneme protein is essential for parasite invasion. We found that a secreted protein with an altered thrombospondin repeat of Toxoplasma gondii (TgSPATR) was a novel microneme protein, which was different from known microneme proteins that carry thrombospondin repeat domains. TgSPATR was secreted in response to an intra-parasitic elevation of Ca2+ and probably secreted during early stages of parasite invasion. Thus, we suggested that TgSPATR, new member of microneme secretory protein, had a possible function in the invasion.
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| Idioma: |
Inglês
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| Identificador: |
http://ir.obihiro.ac.jp/dspace/handle/10322/2819
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| Editor: |
Elsevier
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| Formato: |
application/pdf
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| Direitos: |
Elsevier Ireland Ltd
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