| Registro completo |
| Provedor de dados: |
Anais da ABC (AABC)
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| País: |
Brazil
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| Título: |
Effect of silymarin on sodium fluoride-induced toxicity and oxidative stress in rat cardiac tissues
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| Autores: |
Nabavi,Seyed M.
Nabavi,Seyed F.
Moghaddam,Akbar H.
Setzer,William N.
Mirzaei,Morteza
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| Data: |
2012-12-01
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| Ano: |
2012
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| Palavras-chave: |
Catalase
Glutathione
Sodium fluoride
Superoxide dismutase
Silymarin
TBARS
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| Resumo: |
This study aim to evaluate the protective effect of silymarin on sodium fluoride-induced oxidative stress in rat cardiac tissues. Animals were pretreated with silymarin at 20 and 10 mg/kg prior to sodium fluoride consumption (600 ppm through drinking water). Vitamin C at 10 mg/kg was used as standard antioxidant. There was a significant increase in thiobarbituric acid reactive substances level (59.36 ± 2.19 nmol MDA eq/g tissue) along with a decrease in antioxidant enzymes activity (64.27 ± 1.98 U/g tissue for superoxide dismutase activity and 29.17 ± 1.01 µmol/min/mg protein for catalase activity) and reduced glutathione level (3.8 ± 0.15 µg/mg protein) in the tissues homogenates of the sodium fluoride-intoxicated rats. Silymarin administration to animals before sodium fluoride consumption modified the levels of biochemical parameters.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652012000400026
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| Editor: |
Academia Brasileira de Ciências
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| Relação: |
10.1590/S0001-37652012005000056
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| Formato: |
text/html
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| Fonte: |
Anais da Academia Brasileira de Ciências v.84 n.4 2012
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| Direitos: |
info:eu-repo/semantics/openAccess
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