| Registro completo |
| Provedor de dados: |
BJM
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| País: |
Brazil
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| Título: |
Comparative analysis of two component signal transduction systems of the Lactobacillus acidophilus group
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| Autores: |
Cui,Yanhua
Qu,Xiaojun
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| Data: |
2011-03-01
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| Ano: |
2011
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| Palavras-chave: |
Lactobacillus acidophilus group
Two component system
Histidine protein kinase
Response regulator protein
Bioinformatics analysis
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| Resumo: |
The Lactobacillus acidophilus group is a phylogenetically distinct group of closely related lactobacilli. Members of this group are considered to have probiotic properties and occupy different environmental niches. Bacteria generally sense and respond to environmental changes through two component systems (TCSs) which consist of a histidine protein kinase (HPK) and its cognate response regulator (RR). With the use of in silico techniques, the five completely sequenced L. acidophilus group genomes were scanned in order to predict TCSs. Five to nine putative TCSs encoding genes were detected in individual genomes of the L. acidophilus group. The L. acidophilus group HPKs and RRs were classified into subfamilies using the Grebe and Stock classification method. Putative TCSs were analyzed with respect to conserved domains to predict biological functions. Putative biological functions were predicted for the L. acidophilus group HPKs and RRs by comparing them with those of other microorganisms. Some of TCSs were putatively involved in a wide variety of functions which are related with probiotic ability, including tolerance to acid and bile, production of antimicrobial peptides, resistibility to the glycopeptide antibiotic vancomycin, and oxidative condition.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822011000100019
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| Editor: |
Sociedade Brasileira de Microbiologia
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| Relação: |
10.1590/S1517-83822011000100019
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| Formato: |
text/html
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| Fonte: |
Brazilian Journal of Microbiology v.42 n.1 2011
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| Direitos: |
info:eu-repo/semantics/openAccess
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