| Registro completo |
| Provedor de dados: |
BJPS
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| País: |
Brazil
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| Título: |
Effect of stearic acid on the properties of metronidazole/methocel K4M floating matrices
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| Autores: |
Lara-Hernández,Belem
Hernández-León,Alejandra
Villafuerte-Robles,Leopoldo
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| Data: |
2009-09-01
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| Ano: |
2009
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| Palavras-chave: |
Metronidazole
Methocel K4M
Stearic acid
Matrices hydration
Gastric retention
Sodium bicarbonate
Sustained release
Drugs/release mechanism
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| Resumo: |
The properties of metronidazole/Methocel K4M sustained release floating tablets have been studied varying the proportion of the lubricant, stearic acid, on formulations with and without sodium bicarbonate. The variables studied include technological properties of the tablets such as tablet hardness and ejection pressure, the drug release profile, the hydration kinetics and the floating behaviour. The presence of stearic acid and sodium bicarbonate improves the floating behaviour for more than 8 hours. The hydration volume, the tablet hardness and the ejection pressure decrease as the stearic acid content increases and the polymer content decreases. Drug dissolution increases with increasing proportions of stearic acid and decreasing proportions of the polymer in the tablets. The presence of sodium bicarbonate extends the differences in dissolution produced by stearic acid. These results are attributed to decreasing matrices coherence with an increasing quantity of stearic acid and a reducing polymer proportion. The carbon dioxide bubbles produced by sodium bicarbonate expand the matrices facilitating the dissolution, although their presence obstructs also the diffusion path through the hydrated gel layer.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502009000300016
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| Editor: |
Universidade de São Paulo, Faculdade de Ciências Farmacêuticas
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| Relação: |
10.1590/S1984-82502009000300016
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| Formato: |
text/html
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| Fonte: |
Brazilian Journal of Pharmaceutical Sciences v.45 n.3 2009
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| Direitos: |
info:eu-repo/semantics/openAccess
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