| Registro completo |
| Provedor de dados: |
Scientia Agricola
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| País: |
Brazil
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| Título: |
Variants in GH, IGF1, and LEP genes associated with body traits in Santa Inês sheep
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| Autores: |
Machado,Alessandro Lima
Meira,Ariana Nascimento
Jucá,Adriana de Farias
Azevedo,Hymerson Costa
Muniz,Evandro Neves
Coutinho,Luiz Lehmann
Mourão,Gerson Barreto
Pedrosa,Victor Breno
Pinto,Luís Fernando Batista
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| Data: |
2021-01-01
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| Ano: |
2021
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| Palavras-chave: |
Hormone
Carcass
Growth
Haplotype
Ovine
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| Resumo: |
ABSTRACT: Growth hormone (GH), insulin-like growth factor 1 (IGF1), and leptin (LEP) can be candidate genes for association studies because they play vital roles in the metabolism process. Thus, this study aimed to identify variants in these genes associated with body traits in Santa Inês sheep. The following were recorded: body weight at 100 (BW100) and 240 days (BW240), average daily gain (ADG), withers (WH) and croup (CH) heights, body length (BL), thoracic (TG) and leg (LG) girths, thoracic (TW) and croup (CW) widths, body depth (BD), rib eye area (REA), fat thickness (FT), and carcass finishing score (CFS). Single-locus association analysis was performed with 11 variants in IGF1, 18 in LEP, and 16 in GH. Moreover, two haplotypes in IGF1 and one haplotype in LEP were evaluated in haplotype association analysis. The single-locus analysis revealed 23 suggestive additive effects (p < 0.05), but no additive effect was found at the Bonferroni threshold. Haplotype association analysis revealed 19 additive effects, of which ten were at the Bonferroni threshold (p < 0.0074). In IGF1 gene, haplotype replacements were associated with ADG 20.51(7.37), CH 4.09(1.21), WH 3.52(1.20), BL 3.94(1.19), TG 3.88(1.30), TW 1.13(0.36), and LG 3.40(1.08); while in the LEP gene the haplotype replacement was associated with BW100 1.83(0.51), BD −2.51(0.56), and CFS −0.24(0.06). Therefore, there are haplotypes in IGF1 and LEP genes associated with body traits in Santa Inês sheep, which can be useful in marker-assisted selection.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-90162021000300401
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| Editor: |
São Paulo - Escola Superior de Agricultura "Luiz de Queiroz"
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| Relação: |
10.1590/1678-992x-2019-0216
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| Formato: |
text/html
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| Fonte: |
Scientia Agricola v.78 n.3 2021
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| Direitos: |
info:eu-repo/semantics/openAccess
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