Consulta: subjectFacets:"Alkaloids"
Registros recuperados: 26
Data/hora: 13/06/2024 13:52:42

Actividad antioxidante de alcaloides de Erythrina americana Miller.
Provedor de dados: 32
Autores: Ibarra Estrada, Emmanuel.
Los alcaloides son compuestos que presentan efectos fisiológicos y propiedades farmacológicas a bajas concentraciones. Los objetivos de este estudio fueron extraer y aislar fracciones crudas de alcaloides y el compuesto erisodina de semillas de E. americana, estimar sus rendimientos y evaluar la actividad antioxidante de fracciones crudas de alcaloides y del compuesto puro erisodina. La actividad antioxidante de las fracciones de alcaloides libres hexánicos, libres metanólicos, liberados metanólicos y de erisodina se evaluó mediante el método del radical estable 2,2-difenil-1-picrilhidrazilo (DPPH) que al reaccionar con un antirradical sufre una decoloración de azul-violeta a amarillo; dicha reacción se midió espectrofotométricamente. Entre las fracciones...
Palavras-chave: Radical libre; Antirradical; Erisodina; Alcaloides; Erythrina americana; Free radical; Antiradical; Erysodine; Alkaloids; Maestría; Fisiología Vegetal.
Ano: 2010
URL: http://hdl.handle.net/10521/221

Estrategias nutricionales para mejorar la respuesta productiva de cerdos en engorda.
Provedor de dados: 32
Autores: Martínez Aispuro, José Alfredo.
El presente trabajo tuvo como objetivo reducir y/u optimizar la concentración de algunos nutrimentos en las dietas de cerdos de engorda que puede resultar benéfica en la formulación de raciones. Se realizaron 3 experimentos para evaluar el nivel de lisina, el uso de alcaloides y xilanasas en dietas para cerdos de engorda. En el experimento 1 se determinaron los niveles óptimos biológicos (NOB) de lisina total para cerdos en las etapas de crecimiento y finalización en el comportamiento productivo, las características de la canal, y la concentración de urea en plasma. El NOB para ganancia diaria de peso (GDP), conversión alimenticia, y ganancia de carne magra fue 0.88% de lisina total; mientras que el NOB para consumo de alimento fue 0.961% de lisina total....
Palavras-chave: Lisina; Alcaloides; Dietas con baja proteína; Xilanasas; Energía; Proteína; Lysine; Alkaloids; Low protein diets; Xylanase; Energy; Protein; Ganadería; Doctorado.
Ano: 2013
URL: http://hdl.handle.net/10521/2159

Actividad antioxidante de alcaloides de Erythrina americana Miller.
Provedor de dados: 32
Autores: Ibarra Estrada, Emmanuel.
Los alcaloides son compuestos que presentan efectos fisiológicos y propiedades farmacológicas a bajas concentraciones. Los objetivos de este estudio fueron extraer y aislar fracciones crudas de alcaloides y el compuesto erisodina de semillas de E. americana, estimar sus rendimientos y evaluar la actividad antioxidante de fracciones crudas de alcaloides y del compuesto puro erisodina. La actividad antioxidante de las fracciones de alcaloides libres hexánicos, libres metanólicos, liberados metanólicos y de erisodina se evaluó mediante el método del radical estable 2,2-difenil-1-picrilhidrazilo (DPPH) que al reaccionar con un antirradical sufre una decoloración de azul-violeta a amarillo; dicha reacción se midió espectrofotométricamente. Entre las fracciones...
Palavras-chave: Radical libre; Antirradical; Erisodina; Alcaloides; Erythrina americana; Free radical; Antiradical; Erysodine; Alkaloids; Maestría; Fisiología Vegetal.
Ano: 2010
URL: http://hdl.handle.net/10521/221

Developmental Methylome of the Medicinal Plant Catharanthus roseus Unravels the Tissue-Specific Control of the Monoterpene Indole Alkaloid Pathway by DNA Methylation
Provedor de dados: 5
Autores: Dugé De Bernonville, Thomas; Maury, Stéphane; Delaunay, Alain; Daviaud, Christian; Chaparro, Cristian; Tost, Jörg; O’connor, Sarah Ellen; Courdavault, Vincent.
Catharanthus roseus produces a wide spectrum of monoterpene indole alkaloids (MIAs). MIA biosynthesis requires a tightly coordinated pathway involving more than 30 enzymatic steps that are spatio-temporally and environmentally regulated so that some MIAs specifically accumulate in restricted plant parts. The first regulatory layer involves a complex network of transcription factors from the basic Helix Loop Helix (bHLH) or AP2 families. In the present manuscript, we investigated whether an additional epigenetic layer could control the organ-, developmental- and environmental-specificity of MIA accumulation. We used Whole-Genome Bisulfite Sequencing (WGBS) together with RNA-seq to identify differentially methylated and expressed genes among nine samples...
Tipo: Text
Palavras-chave: Alkaloids; DNA methylation; Epigenetics; Folivory; Organs; Plant specialized metabolism.
Ano: 2020
URL: https://archimer.ifremer.fr/doc/00652/76453/77543.pdf

Bufotenine is able to block rabies virus infection in BHK-21 cells
Provedor de dados: 80
Autores: Vigerelli,Hugo; Sciani,Juliana Mozer; Jared,Carlos; Antoniazzi,Marta Maria; Caporale,Graciane Maria Medeiros; Silva,Andréa de Cássia Rodrigues da; Pimenta,Daniel C.
Background Rabies is a fatal zoonotic neglected disease that occurs in more than 150 countries, and kills more than 55.000 people every year. It is caused by an enveloped single stranded RNA virus that affects the central nervous system, through an infection initiated by the muscular nicotinic acetylcholine receptor, according to many authors. Alkaloids, such as acetylcholine, are widespread molecules in nature. They are present in numerous biological fluids, including the skin secretion of many amphibians, in which they act (together with proteins, peptides and steroids) as protection agents against predators and/or microorganisms. Among those amphibians that are rich in alkaloids, there is the genus Rhinella.Methods Bufotenine was isolated from Rhinela...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Rabies; Rhinella; Bufotenine; Alkaloids; Toxins; Mass spectrometry.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992014000200336

Bromopyrrole alkaloids from the Caribbean sponge Agelas cerebrum
Provedor de dados: 20
Autores: Regalado, E.L.; Laguna, A.; Mendiola, J.; Thomas, O.P.; Nogueiras, C.
Bioguided fractionation of Agelas cerebrum crude extract resulted in isolation of four bromopyrrole and four bromopyrrole aminoimidazole alkaloids, identified as 5-bromopyrrole-2-carboxylic acid (1), 4-bromopyrrole-2-carboxylic acid (2), 3,4-bromopyrrole-2-carboxylic acid (3), 4,5-bromopyrrole-2-carboxylic acid (4), oroidin (5), bromoageliferin (6), dibromoageliferin (7) and dibromosceptrin (8) on the basis of spectroscopic data analyses (UV, IR, HRMS, 1D and 2D NMR) and comparison with literature data. This is the first report of compounds 2 and 3 in a marine sponge belonging to the Agelas genus and the first evidence of the presence of 1 from a natural source.
Tipo: Journal Contribution
Palavras-chave: Alkaloids; Sponges; Chemistry; Chemistry; Alkaloids; Sponges; Http://aims.fao.org/aos/agrovoc/c_1522; Http://aims.fao.org/aos/agrovoc/c_269; Http://aims.fao.org/aos/agrovoc/c_7321.
Ano: 2010
URL: http://hdl.handle.net/1834/3862

Parazoanthines A-E: Hydantoin Alkaloids from the Mediterranean Sea Anemone Parazoanthus axinellae
Provedor de dados: 20
Autores: Cachet, N.; Genta-Jouve, G.; Regalado, E.L.; Mokrini, R.; Amade, P.; Culioli, G.; Thomas, O.P.
Five new hydantoin alkaloids, named parazoanthines A-E (1-5), were isolated as the major constituents of the Mediterranean sea anemone Parazoanthus axinellae. Their structural elucidation was achieved through NMR spectroscopic and mass spectrometric analyses. The absolute configuration of the chiral compounds 1 and 4 was determined by comparison between experimental and TDDFT calculated CD spectra. The configuration of the trisubstituted double bond of 2, 3, and 5 was deduced from the 3JH6-C4 coupling constant value. This family of alkaloids represents the first example of natural 3,5- disubstituted hydantoins which do not exhibit a methyl at N-3. All compounds were tested for their natural toxicity (Microtox® assay) and parazoanthine C (3) exhibited the...
Tipo: Journal Contribution
Palavras-chave: Alkaloids; Alkaloids; Http://aims.fao.org/aos/agrovoc/c_269.
Ano: 2009
URL: http://hdl.handle.net/1834/3864

Ergot Disease of Pearl Millet
Provedor de dados: 30
Autores: R.P.
Palavras-chave: Millets; Hybrids; Alkaloids; Agronomic characters; Self pollination; Fungi; Grain; Yield losses; Cultural control; Integrated control.
Ano: 1990
URL: http://agropedia.iitk.ac.in/openaccess/?q=node/4083

The genus &lt;i&gt;Batzella&lt;/i&gt;: a chemosystematic problem
Provedor de dados: 27
Autores: Van Soest, R.W.M.; Braekman, J.C.; Faulkner, D.J.; Hajdu, E.; Harper, M.K.; Vacelet, J.
Biogenetically unrelated cyclic guanidine alkaloids and pyrroloquinoline alkaloids have been reported from sponges assigned to the genus &lt;i&gt;Batzella&lt;/i&gt;. These sponges have been assigned to this genus because of their possession of a simple complement of thin strongyles in irregular plumoreticulate arrangement. Cyclic guanidine alkaloids were first reported from an alleged axinellid species from the Caribbean, &lt;i&gt;Ptilocaulis&lt;/i&gt; aff. &lt;i&gt;P. spiculifer&lt;/i&gt;, and subsequently from a second Carribean specimen identified as &lt;i&gt;Ptilocaulis spiculifer&lt;/i&gt; and at the same time from a Red Sea poecilosclerid, &lt;i&gt;Hemimycale&lt;/i&gt; sp. Closely related compounds were described from a Caribbean specimen identified...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Alkaloids; Chemotaxonomy; Batzella; Poecilosclerida.
Ano: 1996
URL: http://www.vliz.be/imisdocs/publications/303650.pdf

Mortality of Plutella xylostella larvae treated with Aspidosperma pyrifolium ethanol extracts
Provedor de dados: 86
Autores: Trindade,Roseane Cristina Prédes; Silva,Paulo Pedro da; Araújo-Júnior,João Xavier de; Lima,Ivanildo Soares de; Paula,José Elias de; Sant'Ana,Antônio Euzébio Goulart.
The objective of this work was to assess the effects of Aspidosperma pyrifolium ethanol extracts on cabbage moth (Plutella xylostella) larvae. The ethanol extracts of the stem bark, fruits and roots of A. pyrifolium were obtained by classical phytochemical methods, and the resulting subfractions were tested on P. xylostella, using 4 and 5 mg L-1. The crude ethanol extract of the stem bark was more lethal. The alkaloid-rich aqueous subfraction derived from the stem bark extract caused 100% larval mortality at 4 mg L-1. Insecticidal activity was associated with the presence of the monoterpenoid indole alkaloids aspidofractinine, 15-demethoxypyrifoline, and N-formylaspidofractinine. These alkaloids presented excellent insecticidal properties against P....
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Alkaloids; Cabbage moth; Insecticidal activity; Organic extracts; Pereiro-do-sertão.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-204X2008001200024

Alkaloids in Solanum torvum Sw (Solanaceae): (With 2 Tables &amp;amp; 1 Figure)
Provedor de dados: 85
Autores: Pérez-Amador,MC; Muñoz Ocotero,V; García Castañeda,JM; González Esquinca,AR.
A comparison was made between plants of Solanum torvum Sw that grow in Chiapas, Mexico, and plants of the same species originating from India. This was effected to establish either similarities or differences between these plants in total alkaloid contents and presence of solasodine, an important alkaloid for the partial synthesis of steroids. The total alkaloid content (0.12%) of the plants coming from Chiapas and India was the same. However, solasodine was found only in the plants of Chiapas. In addition, the total amount of glycoalkaloids (0.038%) and two glycosilated compounds derived from solasodine, solasonine (0.0043%) and solamargine (0.0028%), were determined.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Solanaceae; Solanum torvum; Alkaloids; Solasodine; Solamargine.
Ano: 2007
URL: http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S1851-56572007000100004

ASSESSMENT OF BENZOPHENANTHRIDINE AND PROTOPINE ALKALOIDS IN BROILER CHALLENGED AND NOT BY SALMONELLA HEIDELBERG
Provedor de dados: 89
Autores: Previato do Amaral,PFG; Otutumi,LK; Rodrigues,GV; Lima,ET; Fernandes,JIM; Vendrame,A; Mezalira,TS; Suenaga,SS; Sestari,DAO; Cestari,IED; Martins,LA.
ABSTRACT Salmonellosis is a globally important zoonosis, and Salmonella Heidelberg is one of the most prevalent serovars in poultry production worldwide, as well as in food poisoning cases. Antimicrobial drugs were previously widely used to face health challenges in animal production; however, since their ban as performance enhancers, many alternative strategies have been proposed. One of these strategies is the use of plant extracts, such as those containing the alkaloids benzophenanthridine and protopine. These compounds have antimicrobial, anti-inflammatory, immunomodulation, and nutritional effects. The objective of the present study was to evaluate the effects of the supply of a product containing benzophenanthridine and protopine (Sangrovit(r)WS 100...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Alkaloids; Broilers; Intestinal morphology; Performance; Sanguinarine.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-635X2016000300525

Ajmalicine Bioproduction in Catharanthus Roseus (L) G. Don Inoculated with Arbuscular Mycorrhiza and Fertilized with Nitrogen
Provedor de dados: 90
Autores: Monnerat,Cecília Silva; Freitas,Marta Simone Mendonça; Vieira,Ivo José Curcino; Martins,Marco Antônio; Carvalho,Almy Junior Cordeiro de; Santos,Paulo Cesar dos; Lima,Thaísa Capato.
ABSTRACT Catharanthus roseus (L) G. Don (Madagascar periwinkle) belongs to the Apocynaceace family and is widely spread throughout tropical and subtropical regions of the world. The plant produces several important alkaloids, such as ajmalicine and serpentine, which are used in the treatment of circulatory diseases. The potential of inoculation with arbuscular mycorrhizal fungi (AMF) and nitrogen fertilization to enhance the production of alkaloids was investigated in periwinkle. A greenhouse experiment was carried out to evaluate the effects of arbuscular mycorrhizal fungi and N fertilizer dosages on plant growth, production of ajmalicine, and nutrient content in roots. The concentration of ajmalicine was determined by reverse-phase high-performance...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Periwinkle; Apocynaceae; Alkaloids; Plant nutrition.
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-06832018000100416

Secondary metabolismin in Annonaceae: potencial source of drugs
Provedor de dados: 94
Autores: Martínez-Vázquez,Mariano; Estrada-Reyes,Rosa.
Several species of Annona (Annonaceae) are used in traditional Mexican medicine by their anti-anxiety, anticonvulsant and tranquilizing properties. It has been reported that the alkaloids isolated from some species of the Annona have affinity to serotonergic 5-HT1A receptors and modulate dopaminergic transmission, which is involved in depressive disorders. In this review it is showed the results of the antidepressant-like effect of an alkaloid extract from the aerial parts of Annona cherimola (TA) in mice. The antidepressant-like effect was evaluated in the forced swimming test. To elucidate a possible mechanism of action, experiments of synergism with antidepressant drugs, such as imipramine (IMI), clomipramine (CLIMI), and fluoxetine (FLX), were carried...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Antidepressant; Alkaloids; Annona sp.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-29452014000500017

State of the art in Cassia grandis L. f. (cañandonga)
Provedor de dados: 98
Autores: Lafourcade Prada,Ariadna; Rodríguez Amado,Jesús Rafael; Escalona Arranz,Julio César; Laurido Fuenzalida,Claudio.
Introduction: the species Cassia grandis L. f. (cañandonga) is recognized by the Cuban Health System and the population for its antianemic properties, in spite of the unpleasant odor of its fruit. Objectives: to perform a bibliographic update about the chemical, toxicological and pharmacologic characteristics of the study species. Methods: an extensive review was conducted in international databases such as HighWire, DOAJ, EBSCO, Scielo, Scopus, Chemical Abstract, Medline, PudMed, and Pharmaceutical Abstract, in addition to the national database CuMed from the year 1900 until 2012. Results: there are still not enough studies that certify its usefulness and pharmaco-toxicological safety as antianemic, and few pharmaceutical formulations have been developed....
Tipo: Journal article
Palavras-chave: Cassia grandis; Antianemic; Anemia; Anthraquinones; Alkaloids.
Ano: 2014
URL: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S1028-47962014000100004

Differences in wing melanization and pigmentation pattern in Drosophila buzzatii (Diptera: Drosophilidae) under chemical stress
Provedor de dados: 99
Autores: Mongiardino Koch,Nicolás; Hasson,Esteban; Soto,Ignacio M.
Recently, the genetic basis and developmental mechanisms underlying the process of melanization have become progressively elucidated, allowing us to study the evolutionary processes that govern the huge variability of pigmentation observed in nature. However, environmental factors contributing to such variability have received little attention, even though they might have profound ecological consequences. Here we describe a method for analyzing the wing melanization patterns of drosophilids in both qualitative and quantitative ways. We test this method on wings of Drosophila buzzatii Patterson &amp;amp; Wheeler individuals, reared in control and alkaloid-enriched mediums. The alkaloids were extracted from the secondary host of these flies, Echinopsis...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Drosophila buzzatii; Melanin; Ecotoxicology; Alkaloids; Stress.
Ano: 2012
URL: http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S0373-56802012000100008

Sustainable production of bioactive alkaloids in Psychotria L. of southern Brazil: propagation and elicitation strategies
Provedor de dados: 39
Autores: Magedans,Yve Verônica da Silva; Rodrigues-Corrêa,Kelly Cristine da Silva; Costa,Cibele Tesser da; Matsuura,Hélio Nitta; Fett-Neto,Arthur Germano.
ABSTRACT Psychotria is the largest genus in Rubiaceae. South American species of the genus are promising sources of natural products, mostly due to bioactive monoterpene indole alkaloids they accumulate. These alkaloids can have analgesic, antimutagenic, and antioxidant activities in different experimental models, among other pharmacological properties of interest. Propagation of genotypes with relevant pharmaceutical interest is important for obtaining natural products in a sustainable and standardized fashion. Besides the clonal propagation of elite individuals, the alkaloid content of Psychotria spp. can also be increased by applying moderate stressors or stress-signaling molecules. This review explores advances in research on methods for plant...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Abiotic stress; Alkaloids; Elicitation; Monoterpenes; Plant propagation; Psychotria; Southern Brazil; Sustainability.
Ano: 2019
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-33062019000400607

Synthesis of Chiral 1,3-Dienes through Ring-Closing Metathesis of Enantioenriched Enynes: Potential Precursors of Morphane Analogs
Provedor de dados: 42
Autores: GARCIA-MUÑOZ,MARÍA JESÚS; SIRVENT,ANA; FOUBELO,FRANCISCO; YUS,MIGUEL.
ABSTRACT A simple methodology for the synthesis of enynes by indium mediated diastereoselective allylation of aromatic N-tert-butanesulfinylimines bearing alkenyl groups at ortho-position with allyl bromide has been developed. The addition of the allyl indium intermediate to the chiral imine took place with excellent diastereoselectivity. Ruthenium-catalyzed ring-closing metathesis of the resulting enynes provided the expected cyclic 1,3-dienes in good to moderate yields. These chiral dienes are potential precursors of biologically and pharmacologically active morphane derivatives.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Allylation; Imines; Dienes; Enynes; Metathesis; Alkaloids.
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652018000301059

Cytotoxicity and bacterial membrane destabilization induced by Annona squamosa L. extracts
Provedor de dados: 42
Autores: PINTO,NÍCOLAS C.C.; SILVA,JUCÉLIA B.; MENEGATI,LAURA M.; GUEDES,MARIA CLARA M.R.; MARQUES,LUCAS B.; SILVA,THIAGO P. DA; MELO,ROSSANA C.N. DE; SOUZA-FAGUNDES,ELAINE M. DE; SALVADOR,MARCOS J.; SCIO,ELITA; FABRI,RODRIGO L.
ABSTRACT This study aimed to further investigate the cytotoxicity against tumor cell lines and several bacterial strains of Annona squamosa and its mode of action. Methanol extracts of A. squamosa leaves (ASL) and seeds (ASS) were used. ASL showed significant antibacterial activity against S. aureus, K. pneumoniae and E. faecalis with MIC values of 78, 78 and 39 µg/mL respectively. Moreover, ASL exhibited significant biofilm disruption, rapid time dependent kinetics of bacterial killing, increased membrane permeability and significantly reduced the cell numbers and viability. Regarding the cytotoxicity against tumor cell lines, ASS was more active against Jurkat and MCF-7 cells, with CI50 1.1 and 2.1 µg/mL, respectively. ASL showed promising activity...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Alkaloids; Annona squamosa; Antibacterial; Citotoxicity; Herbal medicine.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652017000502053

Secondary metabolites from marine microorganisms
Provedor de dados: 42
Autores: KELECOM,ALPHONSE.
After 40 years of intensive research, chemistry of marine natural products has become a mature field. Since 1995, there are signals of decreased interest in the search of new metabolites from traditional sources such as macroalgae and octocorals, and the number of annual reports on marine sponges stabilized. On the contrary, metabolites from microorganisms is a rapidly growing field, due, at least in part, to the suspicion that a number of metabolites obtained from algae and invertebrates may be produced by associated microorganisms. Studies are concerned with bacteria and fungi, isolated from seawater, sediments, algae, fish and mainly from marine invertebrates such as sponges, mollusks, tunicates, coelenterates and crustaceans. Although it is still to...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Bacteria; Fungi; Alkaloids; Despsipeptides; Terpenoids; Acetogenins; Biological activities.
Ano: 2002
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652002000100012

Plant-derived antimalarial agents: new leads and efficient phythomedicines. Part I. Alkaloids
Provedor de dados: 42
Autores: Oliveira,Alaíde B.; Dolabela,Maria Fâni; Braga,Fernão C.; Jácome,Rose L.R.P.; Varotti,Fernando P.; Póvoa,Marinete M.
Malaria remains one of the most serious world health problem and the major cause of mortality and morbidity in the endemic regions. Brazil is among the 30 high-burden countries and most of the cases occur in the Legal Amazonian Region. New chemotherapeutical agents are needed for the treatment of malaria. Many plant species are used in traditional medicines of malarious countries and a relatively few number of these have been investigated for evaluation of their antimalarial effect. Still lower is the number of those that have had the active natural compounds isolated and the toxicity determined. This area is, then, of great research interest. discovery project of antimalarial natural products from plants traditionally used to treat malaria must include in...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Natural products; Alkaloids; Antimalarial activity; Medicinal plants; Phytomedicines.
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652009000400011

Therapeutic effects of Sophora moorcroftiana alkaloids in combination with albendazole in mice experimentally infected with protoscolices of Echinococcus granulosus
Provedor de dados: 56
Autores: Ma,X.M.; Bao,G.SH.; Wan,J.M.; Liao,D.J.; Yin,SH.F.; Meng,X.Q.; Zhou,G.K.; Lu,X.M.; Li,H.Y.
The objective of the present study was to determine if the combination of alkaloids from Sophora moorcroftiana seeds and albendazole might be effective in the treatment of experimental echinococcosisin female NIH mice (6 weeks old and weighing 18-20 g, N = 8 in each group) infected withprotoscolices of Echinococcus granulosus. Viable protoscolices (N = 6 x 103) were cultured in vitro in 1640 medium and mortality was calculated daily. To determine the in vivo efficacy, mice were inoculated intraperitoneally with viable protoscolices and then treated once daily by gavage for three months with the alkaloids (50 mg kg-1 day-1) and albendazole (50 mg kg-1 day-1), separately and in combination (both alkaloids at 25 mg kg-1 day-1 and albendazole at 25 mg kg-1...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Sophora moorcroftiana; Echinococcus granulosus; Alkaloids; Cytokines; Ethnobotany; Therapeutics.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007001000014

Evaluation of the effects of Uncaria rhynchophylla alkaloid extract on LPS-induced preeclampsia symptoms and inflammation in a pregnant rat model
Provedor de dados: 56
Autores: Wu,Liang-Zhi; Xiao,Xiao-Min.
Excessive pro-inflammatory cytokines result in adverse pregnancy outcomes, including preeclampsia-like phenotypes, and fetal growth restriction. Anti-inflammation might be an effective therapy. The aim of this research was to investigate whether Uncaria rhynchophylla alkaloid extract (URE), a highly safe anti-inflammation constituent of the herb, can inhibit inflammation and improve clinical characteristics of preeclampsia in a lipopolysaccharide (LPS)-induced preeclampsia rat model. The rat model was established by daily administration of LPS (1 μg/kg body weight per day) from gestational day (GD) 14 to 19. Different doses of URE (35, 70, and 140 mg/kg body weight per day) were administered from GD 14 to GD 19. The effects of URE on proteinuria, maternal...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Preeclampsia; Inflammation; Uncaria rhynchophylla; Alkaloids.
Ano: 2019
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2019000600602

Application of HPLC-DAD for the quantification of Lycorine in Galanthus elwesii Hook
Provedor de dados: 60
Autores: Emir,Ahmet; Emir,Ceren; Bozkurt,Buket; Onur,Mustafa Ali; Somer,Nehir Unver; Kaya,Gulen Irem.
ABSTRACT In the present study, a reversed-phase high-performance liquid chromatographic method has been used for the quantitative determination of lycorine in the aerial parts and bulbs of G. elwesii Hook. A simple method for the extraction of lycorine in low mass plant samples was employed utilizing pre-packed columns with diatomaceous earth (Extrelut(r)). The chromatographic separation was performed using an isocratic system with a mobile phase of trifluoroacetic acid-water-acetonitrile (0.01:92.5:7.5, v/v/v) applied at a flow rate 1 mL min-1 using diode array detector. The content of lycorine in the bulbs and aerial parts of G. elwesii collected from Demirci (Manisa) was found as 0.130 and 0.162 %, respectively. Additionally, in the bulbs of the...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Alkaloids; Amaryllidaceae; Plant extracts; High Performance Liquid Chromatography/method validation; High Perfomance Liquid Chromatography/quantitative analysis.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502017000100603

Ipomoea brasiliana poisoning on buck reproduction
Provedor de dados: 65
Autores: Cunha,Ana Lizia Brito da; Medeiros,Juliana Pinto de; Riet-Correa,Franklin; Gardner,Dale; Chaves,Hisadora Advíncula da Silva; Silva Filho,Givaldo Bom da; Souza,Francisco de Assis Leite; Evêncio Neto,Joaquim; Mendonça,Fábio de Souza.
ABSTRACT:  Swainsonine-containing plants comprise a group of important poisonous plants in Brazil. This research aimed to characterize both the behavioral changes related to reproduction and appearance of lesions in the reproductive system of bucks poisoned by Ipomoea brasiliana. I. brasiliana plants were collected and administered at a dose of 4g/kg (800µg swainsonine/kg) to two groups of bucks for 45 days. Goats from Group I were euthanized on the 46th day of the experiment, and goats from Group II were euthanized on the 120th day. Group III was composed of goats that did not receive I. brasiliana and were euthanized on the 120th day of the experiment. Reproductive behavioral changes were observed starting on day 20 and were characterized by an absence...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Alkaloids; Lysosomal storage disease; Plant poisoning; Ruminants.
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782018001000552

Different leaf extracts from Brunfelsia uniflora in mice
Provedor de dados: 65
Autores: Carvalho,Ciro José Sousa de; Melo,Marília Martins; Michell,Ana Flávia Ribeiro Machado; Torres,Bruno Benetti Junta; Riet-Correa,Franklin; Guedes,Roberto Maurício Carvalho; Ferraz,Vany Perpetua; Soto-Blanco,Benito; Silva,Silvana Maria Medeiros de Sousa.
ABSTRACT: In Brazil, at least 16 poisonous plant species can affect the central nervous system of livestock. Recently in the state of Piauí, Northeastern Brazil, Brunfelsia uniflora was reported as a cause of nervous signs in donkeys, cattle, and small ruminants. In order to assess the toxicity of B. uniflora extracts, 20 Swiss mice were distributed into four groups (n=5) receiving by gavage alkaloids, flavonoids, saponins, or saline (control group). After administration of the extracts in a single dose (5g kg-1), all mice were observed daily for clinical signs. Mice that received the extracts showed moderate to severe clinical signs, including piloerection, vocalization, and seizures. All mice dosed with saponins died between 10 and 20min after...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Toxicity; Alkaloids; Saponins; Flavonoids; Brunfelsia; Solanaceae.
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782018000100552