Consulta: subjectFacets:"Ayurvedic herb"
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Data/hora: 12/06/2024 17:06:12

Analysing the antidepressant and drug efflux competence of Clitoria ternatea L. as P-glycoprotein inhibitor to facilitate blood brain barrier
Provedor de dados: 3
Autores: Margret, Arockiya Anita; Dhayabaran, Violet; Suvaithenamudhan, Suvaiarasan; Parthasarathy, Subbiah.
Clitoria ternatea L. is a vital ayurvedic herb featured with a wide spectrum of mental health benefits. The present study investigates the competence of the plant against depression and to inhibit the membrane efflux protein P-glycoprotein (P-gp) that can regulate and restrict drug permeation into the brain. Antidepressant competence of the aqueous plant extract was assessed by animal despair studies on depression induced female mice models. The P-glycoprotein inhibitory potential of active phytocompounds was evaluated by molecular docking assay and substantiated by a cell line study. The in vivo studies exhibited a significant difference in the immobility time thereby establishing antidepressant activity. The histopathological sections from cortex region...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Mental health; Ayurvedic herb; Kaempferol 3-O-(2״ 6״-di-O-rhamnopyranosyl) glucopyranoside; Animal despair studies; Rhodamine transport assay; Molecular docking.
Ano: 2019
URL: http://periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/46629