Consulta: subjectFacets:"Kidney"
Registros recuperados: 74
Data/hora: 13/06/2024 06:04:55

Morphometric Parameters of the Human Adult Kidney: An Anatomical Study
Provedor de dados: 77
Autores: Murlimanju,B.V; Kumar,Buraje Madhuri; Kumar,Naveen; Prashanth,K.U; Rao,Chitra Prakash; Guru,Anitha; Prabhu,Latha V; Kumar,Chettiar Ganesh.
The purpose of this study was to determine the anatomic parameters of the kidney in adults. The Renal lengths, width at superior and inferior poles, thickness at the superior and inferior poles were measured in 151 adult cadaver kidneys. A digital vernier caliper was used for performing the measurements. The data were statistically analyzed. The mean renal length was 8.9 ± 0.9 cm on the right side and 9.1 ± 0.9 cm on the left side. The mean width of the superior pole of the right kidney was 4.9 ± 0.6 cm and the left kidney was 5 ± 0.7 cm. The width of inferior pole of the right and left kidneys were 4.8 ± 0.6 cm and 4.5 ± 0.7 cm respectively. The mean thickness of the superior pole of the right kidney was 3 ± 0.4 cm and left kidney was 3.2 ± 0.5 cm. The...
Tipo: Journal article
Palavras-chave: Inferior pole; Kidney; Length; Morphometry; Superior pole.
Ano: 2014
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022014000200045

Moringa oleifera Impairs the Morphology and Functions of the Kidney in Adult Wistar Rats
Provedor de dados: 77
Autores: Akinlolu,Abdulazeez Adelaja; Ghazali,Olaide Kamal; Ameen,Oloduowo Mubarak; Oyebanji,Seunayo Comfort; Omotoso,Gabriel Olaiya; Enaibe,Bernard Ufuoma.
We tested the hypothesis that Moringa oleifera impairs the morphology and functions of the kidney in rats. Twenty-four adult male Wistar rats were employed in the study. Rats of Control Group I received physiological saline while rats of Groups II ­ IV received 250, 500 and 750 mg/kg bodyweight of methanolic extract of Moringa oleifera respectively for twenty one days. No behavioral anomalies were observed in rats of Groups I ­ IV. Rats of Control Group I gained statistically significant increased bodyweight while rats of Groups II ­ IV experienced non-significant decreased bodyweight during experimental procedure. (P0.05). No statistical significant differences (P0.05) were observed in the analyses of the relative weights of kidneys of rats of Groups I ­...
Tipo: Journal article
Palavras-chave: Moringa oleifera; Toxicity profile; Kidney.
Ano: 2014
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022014000200016

Mixture of Kerosene and Xylene: a Contribution to Clearing Agents
Provedor de dados: 77
Autores: Ofusori,David A; Ayoka,Abiodun O; Adeeyo,Olusola A; Adewole,Stephen O.
The aim of this study was to substitute costly and hazardous compound- xylene, used as clearing agent, with less costly compounds (mixture of xylene and kerosene) having less toxicity and without compromising the cellular integrity and staining characteristics of the sections. Tissues (liver and kidney) obtained from a presumable healthy adult Wistar rat, were fixed in 10% formol saline, separated in to five groups (A, B, C, D and E) and processed for light microscopic study adopting H &amp;amp; E staining procedure. During the clearing section, groups A, B, C, D and E were respectively cleared in solvent 1 (xylene only), solvent 2 (70ml xylene : 30ml kerosene), solvent 3 (50ml xylene : 50ml kerosene), solvent 4 (30ml xylene : 70ml kerosene) and solvent 5...
Tipo: Journal article
Palavras-chave: Xylene; Kerosene; Clearing agent; Liver; Kidney.
Ano: 2009
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022009000100036

Absorption Levels and Morphological Features of Fetal Organs in Wistar Rats Treated with Lead Acetate
Provedor de dados: 77
Autores: Bomfim,Kátia Michelle dos Anjos; Garcia,Carlos Alexandre Borges; Reis,Francisco Prado; Palmeira,José Arnaldo Vasconcelos; Scher,Ricardo; de Lucca Júnior,Waldecy; Aragão,José Adeval; Vasconcelos,Francis Lima; Albuquerque Júnior,Ricardo Luiz Cavalcanti; Feitosa,Vera Lúcia Corrêa.
Lead is one of the heavy metals most used in industry. Poisoning due to long-term lead exposure is known as saturnism, and is an occupational illness that has been known for many years. Lead is highly toxic and can compromise the structural and functional patterns of organs and systems. The aim of this study was to examine the lungs and kidneys of fetuses from female Wistar rats exposed to lead acetate. In this study, the lungs and kidneys of 20 fetuses from female rats that had previously been treated with lead acetate were dissected, fixed, embedded in paraffin and stained with hematoxylin and eosin. Macroscopic changes to the shape, color and consistency of organs from fetuses treated with this heavy metal were observed, in comparison with organs from...
Tipo: Journal article
Palavras-chave: Lead acetate; Fetuses; Lung; Kidney.
Ano: 2012
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022012000100021

Normal and Variant Anatomy of Renal Hilar Structures and its Clinical Significance
Provedor de dados: 77
Autores: Trivedi,S; Athavale,S; Kotgiriwar,S.
Advanced imaging techniques have resulted in increasing use of minimally invasive approaches for nephron sparing surgeries of kidney. Need for precise knowledge of normal and variant anatomy of vascular pedicle of kidney is thus justified. Ample literature is available on the variations in the intrarenal vascular pattern of the kidney, which are seen frequently. But the variation in arrangement of structures at the renal hilum has not gained much interest up till now. One hundred (51 right and 49 left) embalmed kidneys were utilized for the present study. Careful dissection of renal hilar structures was carried out to observe antero-posterior relationship of structures at the hilum of the kidney. In majority (73%), the arrangement was not according to the...
Tipo: Journal article
Palavras-chave: Kidney; Laparoscopic partial nephrectomy; Renal hilum; Variations.
Ano: 2011
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022011000400052

Tangential Algorithm for Calculation of the Fractal Dimension of Kidney Tubuli Sections
Provedor de dados: 77
Autores: Gil,Julio; Gimeno,Miguel; Laborda,Jesús; Nuviala,Javier; Belanche,Ignacio.
We have developed a new algorithm to calculate the fractal dimension of dog kidney proximal convoluted tubule section. This algorithm is intermediate between box-counting and perimeter-stepping algorithms. The result of this new algorithm and correlations found between fractal dimensions and other Euclidian values of these tubuli, suggest that this algorithm is adequate to calculate fractal dimensions by points
Tipo: Journal article
Palavras-chave: Fractal; Kidney; Proximal convoluted tubuli.
Ano: 2006
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022006000100006

Triple Right Renal Vein: An Uncommon Variation
Provedor de dados: 77
Autores: Fernandes,R. M. P.; Conte,F. H. P.; Favorito,L. A.; Abidu-Figueiredo,M.; Babinski,M. A.
We report an unilateral three renal veins the right kidney in an elderly male cadaver. They were three calibrous veins having independent courses up to the inferior vena cava. No other vascular anomalies were noted in this specimen. This anatomical curiosity should be kept in mind by clinicians and academics that may manipulate this anatomical area
Tipo: Journal article
Palavras-chave: Anatomy; Anomalies; Human; Kidney; Vein.
Ano: 2005
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022005000300007

Fractal Dimension of Dog Kidney Proximal Convoluted Tubuli Sections by Mean Box-Counting Algorithm
Provedor de dados: 77
Autores: Gil,Julio; Gimeno,Miguel; Laborda,Jesús; Nuviala,Javier.
The possibility of characterizing the proximal convoluted tubuli of the dog kidney by means of a unique and objective value, is an attractive idea in order to automate its recognition in anatomy and patology. For this, we obtained a fractal dimension of the proximal convoluted tubuli in the dog kidney by mean box-counting method. The fractal value we obtained is a flat dimension, and it is different than the line fractal dimension of the dog kidney arterial pattern, which was previously calculated by us (Gil et al., 2006). Thus, from optical microscopy images, we are able to obtain a single quantitative measure to discriminate these dog kidney components. This measures can use to automate its recognition. Fractal geometry provides many advantages when...
Tipo: Journal article
Palavras-chave: Fractal; Kidney; Proximal convoluted tubuli.
Ano: 2006
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022006000500005

Morphometry and Vascularization of the Rabbit Kidneys (Oryctolagus cuniculus)
Provedor de dados: 77
Autores: Santos-Sousa,C. A; Stocco,A. V; Mencalha,R; Jorge,S. F; Abidu-Figueiredo,M.
Rabbits have been used as urologic models in many studies. The aim of this study was to characterize the renal morphology and anatomical variations of the renal pedicle in rabbit. The research ethics committee of Rio de Janeiro Federal Rural University approved this study. The animals were obtained from the university's necropsy unit. Dissections were performed in 50 adult rabbits, male and females, without macroscopic renal pathology. Kidney measurements were made with a digital caliper: length, width, and thickness. The length and origin of the renal arteries and main branches and length of the renal veins were also determined. The terminology of Nomina Anatomica Veterinaria was followed. The mean and standard deviation of the length of the right kidney...
Tipo: Journal article
Palavras-chave: Blood vessels; Kidney; Measurements; Variability; Rabbit.
Ano: 2015
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022015000400017

Effects of Aspartame on Fetal Kidney: A Morphometric and Stereological Study
Provedor de dados: 77
Autores: Martins,Marielza R Ismael; Azoubel,Reinaldo.
The objective of this study was the evaluation of aspartame effects on morphometric alterations of the glomerulus, proximal and distal convoluted tubules and collecting ducts of the rat fetal kidney during organogénesis. Fifteen pregnant rats averaging 24 g body weight, were divided into 3 groups (n=5 each) of controls, rats treated with aspartame exposed to room temperature and rats treated with aspartame heated to 40°C. Animals were given 14mg / kg aspartame by the intragastric route on the 9th, 10th, and 11th days of pregnancy. Karyometric and stereological techniques estimated morphological changes. A significant decrease of fetal body weight was observed in the group given aspartame kept at room temperature, compared to controls. Karyometry permitted...
Tipo: Journal article
Palavras-chave: Aspartame; Kidney; Morphometry.
Ano: 2007
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022007000400004

A Rare Variation of the Retro-Aortic Left Renal Vein with Anastomotic Afluent from Inferior Mesenteric Vein
Provedor de dados: 77
Autores: Andrade,F. M.; Rocha,R. P.; Pereira,H. M.; Fernandes,R. M. P.; Babinski,M. A.
We report an uncommon anatomical variations of the left renal vein was found on dissected specimen in an elderly male cadaver: a retroaortic left renal vein. No other vascular anomalies were noted in this specimen. The anomaly result may be related to a particular pattern of left inferior vena cava. The abnormality have to be known for it may be undetected or be misleading in imaging. This anatomical curiosity should be kept in mind by clinicians and academics that may manipulate this anatomical area
Tipo: Journal article
Palavras-chave: Anatomy; Anomalies; Kidney; Retroaortic renal vein.
Ano: 2005
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022005000100001

Unilateral Renal Haemangiopericytoma: Report of a Rare Tumour
Provedor de dados: 77
Autores: Ribeiro,J. G. A.; Klojda,C. A. B.; Machado,F. A.; Favorito,L. A.; Cavalcante,A. G. L.; Babinski,M. A.
The pericytes are modified smooth muscle cells (SMCs) that surrounding capillaries and to change the diameter of vascular lumen. In this article we report a case of renal haemangiopericytoma. A 78-year-old woman was admitted with a complaint of abdominal pain. Ultrasonography revealed a solid injury in the third portion of the left kidney. Abdominal CT scan revealed a tumoral mass. Due the high index of suspicion of malignant neoplasia the patient was submitted to left radical nefrectomy. The histopathological evaluation confirmed haemangiopericytoma by immunohistochemistry. The patient fared well and was alive 5 years after radical nephrectomy
Tipo: Journal article
Palavras-chave: Kidney; Tumour; Haemangiopericytoma; Pathology; Immunohistochemistry.
Ano: 2006
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022006000300007

Histology and Renal Lipoperoxidation in Rats Exercised on a Treadmill and Submitted to Water Restriction
Provedor de dados: 77
Autores: Lorençoni,Roselene Modolo Regueiro; Pelai,Elisa Bizetti; Godoy,Moacir Fernandes; dos Santos,Alice Cristina Antonio; Miyoshi,Lívia Hissae; de Oliveira,Rebeca Nicolás Paronetto; Padovani,Carlos Roberto; Fregonesi,Cristina Elena Prado Teles; Camargo Filho,José Carlos Silva.
Physical effort stimulates an increase in oxygen consumption in tissues, generating toxic chemical species derived from oxygen (ROS), which are considered the initiators of the lipid peroxidation process (LPO), the major mechanism of cellular injury. As the essential mechanism for maintaining the electrolyte balance depends on an effective kidney function, oxidative stress in this organ can be a key factor in the development and persistence of hypertension. This study aimed to determine the kidney changes induced by a combination of fluid restriction and exercise in rats. The study consisted of 24 male Wistar rats of 90 days of age, divided into four groups, two of which were submitted to water restriction and exercise on a treadmill.Twenty-four hours...
Tipo: Journal article
Palavras-chave: Morphology; Oxidative Stress; Kidney.
Ano: 2015
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022015000200039

EFFECTS OF SODIUM CYCLAMATE IN KIDNEYS OF RATS FETUSES: A MORPHOMETRIC STUDY
Provedor de dados: 77
Autores: Ferraz de Arruda,José Germano; Tadeu Martins,Alex; Pereira Godoy,José Maria; Fácio Jr,Fernando Nestor; Azoubel,Reinaldo.
The cyclamate is used as artificial non-caloric sweetner in a wide variety of foods and beverages, being 30 times as sweet as sugar without the bitter after-taste of saccharin. It appears in the composition of the products as sodium and calcium cyclamates and cyclamic acid. The purpose of this research was to assess the effect of sodium cyclamate in kidneys of rats fetuses considering morphometric changes of glomerulus, proximal and distal convoluted tubules, and collecting duct. Ten pregnant rat (Rattus norvegicus) weighting an average of 238 g were divided into two groups: 5 in the control group and 5 in treated group with sodium cyclamate. Between the 10th and the 14th pregnancy day, 5 rats received an intraperitoneal daily injection of 60 mg/kg of body...
Tipo: Journal article
Palavras-chave: Kidney; Sodium cyclamate; Morphometry; Experimental study.
Ano: 2004
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022004000200005

Bilateral Origin of the Testicular Arteries from the Lower Polar Accessory Renal Arteries
Provedor de dados: 77
Autores: Panagouli,Eleni; Lolis,Evangelos; Venieratos,Dionysios.
The gonadal arteries (testicular or ovarian arteries) emerge normally from the lateral aspect of the abdominal aorta, a little inferior to the renal arteries. Several other sites of origin of these arteries have been recorded with the renal and accessory renal arteries being the most common. In the present case report, the testicular arteries originated from the lower polar accessory renal arteries in both sides. The testicular veins followed had the usual origin and course, while an accessory renal vein was observed only in the right side. These anomalies were combined with an abnormal left ureter exiting from the lower pole of the kidney. Only one male cadaver among 77 adult human cadavers of Caucasian origin presented this set of variations (frequency:...
Tipo: Journal article
Palavras-chave: Gonadal arteries; Kidney; Ureter; Abdominal aorta.
Ano: 2012
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022012000400010

Radiation Nephritis: Anti-inflammatory Effect of Dexamethasone in Adult Wistar Rats (Rattus norvegicus)
Provedor de dados: 77
Autores: Owoeye,O; Malomo,A. O; Elumelu,T. N; Salami,A. A; Osuagwu,F. C; Akinlolu,A. A; Adenipekun,A; Shokunbi,M. T.
The anti-inflammatory effect of dexamethasone on the irradiated kidneys of adult Wistar rats (Rattus norvegicus) was studied. Eighteen adult Wistar rats were, after acclimatization, randomly divided into 3 groups of 6 animals per group. The control group had normal saline, receiving neither drugs nor radiation. The second group received normal saline and radiation. The third group received pretreatment with dexamethasone at 1mg/kg body weight/day for 2 days followed by radiation. Radiation was delivered to the animals as a single fraction of 2.5 Gy of gamma rays from Cobalt-60 source, using an AECL Theatron 780-C Teletherapy machine. After exposure to the different interventions, the animals were sacrificed on the 14th post-irradiation day and the kidneys...
Tipo: Journal article
Palavras-chave: Radiation; Nephrons; Glomerulus; Nephritis; Anti-inflammatory; Kidney.
Ano: 2008
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022008000100011

Morphological Expression of the Renal Artery: A Direct Anatomical Study in a Colombian Half-caste Population
Provedor de dados: 77
Autores: Saldarriaga,Bladimir; Pinto,Sergio A; Ballesteros,Luis E.
Irrigation of the kidneys is usually provided by a single renal artery; however, variations on this pattern have frequently been reported. This study was aimed at establishing the renal arteries' frequency and morphological characteristics in cadaverous material taken from a half-caste population from Bucaramanga (Colombia). The sample included 195 renal blocks corresponding to 57 (14.6%) kidneys from females and 333 (85.4%) from males. The renal arteries were injected with synthetic resin (palatal GP41L); following the resin's polymerization, the renal blocks were placed in KOH solution for corrosion the renal parenchyma. The individuals from whom the renal blocks, 74.9% of the kidneys presented renal arteries single and 25.1% had additional renal...
Tipo: Journal article
Palavras-chave: Renal artery; Anatomical variations; Kidney.
Ano: 2008
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022008000100005

Morphometric Alterations Induced by the Toxicity of Variable Sizes of Silver Nanoparticles
Provedor de dados: 77
Autores: Almansour,Mansour; Jarrar,Qais; Battah,Abdelkader; Jarrar,Bashir.
Silver nanoprticles (SNPs) are invested in medical, industrial and environmental applications. Little if any, is known about the morphometric alterations induced by the toxicity of SNPs. The aim of the present work is to find out the effect of variable size of SNPs on different morphometric parameters. Adult healthy male mice (BAL/C) were subjected to (10 nm, 20 nm, 40 nm 60 nm and 100 nm) SNPs for 35 days. Silver NPs caused non-significant decline on the average weight, significant decline in food consumption, increase in water intake, unilateral blindness, tanning fur color and cholestasis together with a decrease in the relative ratio of the liver, kidney and spleen weight to body weight. Mice subjected to 10 nm and 20 nm were more affected than mice...
Tipo: Journal article
Palavras-chave: Silver nanoparticles; Morphology; Toxicology; Liver; Kidney; Spleen.
Ano: 2015
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022015000200022

Can Formaldehyde Exposure Induce Histopathologic and Morphometric Changes on Rat Kidney?
Provedor de dados: 77
Autores: Golalipour,Mohammad Jafar; Azarhoush,Ramin; Ghafari,Soraya; Davarian,Ali; Fazeli,Seyyed Amirhossein.
Formaldehyde is used traditionally for fixing the cadaver, and vaporized during dissection and practical studying on cadaver. This study was designed to determine the histopathologic and morphometric changes of rat kidney while all of the experiments were exposed to formaldehyde for 18 weeks. 28 male albino Wistar rats were divided into the following three experimental groups (E1: 2hrs/d, 2d/w; E2: 2hrs/d, 4d/w; E3: 4hrs/d, 4d/w) and one control group (C). when the exposure period was expired the animals were anaesthetized with chloroform. After cervical dislocation, the abdomen was dissected and the kidneys were taken. The kidney specimens were sectioned and stained with Haematoxylin and Eosin technique for histologic and morphometric study. Data were...
Tipo: Journal article
Palavras-chave: Formaldehyde; Exposure; Histology; Kidney; Rat; Morphometry.
Ano: 2009
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022009000400037

Atorvastatin Has no Effects on Kidney Tissues of Wistar Albino Rats in the Long-Term Intake: An Electron Microscopic Study
Provedor de dados: 77
Autores: Aktas,Ayfer; Serhan Tasdemir,M; Cudi Tuncer,M; Nergiz,Yusuf; Akkus,Murat; Bagriyanik,Hüsnü Alper.
In this study, we evaluated the ultrastructural findings of kidney with systemic administration of different doses of atorvastatin in a rat model. Statins may have anti-inflammatory effects that would play a role in preventing the cellular damage. The aim of this study was to investigate how atorvastatin could play a role in kidney tissues. Forty adult male Wistar albino rats (200­250 g) were randomly divided into 4 groups of ten rats each (A1, A2, A3 and Control). Three different doses of atorvastatin were used to determine the effects on kidney tissues during 90 day period. The kidneys of A1 (0.1-mg group), A2 (0.5-mg group) and A3 (1-mg group) group were excised and the tissues were examined after the 90 days by transmission electron microscopy. Despite...
Tipo: Journal article
Palavras-chave: Kidney; Wistar-albino rat; Statins; Atorvastatin; Ultrastructural.
Ano: 2011
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022011000100025

Morphogenesis of Kidney in Crossbred Pig (Sus scrofa) Foetii
Provedor de dados: 77
Autores: Sarma,Kamal; Ahmed,Bilal.
Twenty five numbers of crossbred pig foetii were selected based on their crown-rump length and subsequently divided into 5 age groups consisting of 5 animals in each group viz. group I (41-55 days), group II (56-70 days), group III (71-85 days), group IV (86-100 days) and groupV (101-114 days). No renal pelvis was evident in group I in all the kidneys under study. From group II onwards, the renal pelvis was distinct and extensive with a well developed ureter that originated from the middle of the pelvis in both the kidneys
Tipo: Journal article
Palavras-chave: Crossbred pig; Kidney; Ontogeny.
Ano: 2007
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022007000100019

Histopathologic Effect of Persea americana Aqueous Leaves Extract on the Liver and Kidney of Weaner Rabbits (California Species)
Provedor de dados: 77
Autores: Adisa,J. O; Ajayi,Y; Egbujo,E. C.
Persea americana (avocado) is widely grown in parts of Southeastern Nigeria and used as a medicinal plant in the treatment of several ailments by alternative medical practitioners but very little research has been carried out on its pharmacotoxicity. This study therefore intends to study the histopathologic effect(s) of Persea americana aqueous leaf extract on the liver and kidneys of rabbits. Fresh leaves of Persea americana were processed using the Soxhlet extraction to obtain the aqueous extract. Three (3) groups of weaner rabbits namely the control, the recommended dose and the high dose groups were given water, 75mg/kg/ and 150mg/kg per day of the extract respectively for 28 days. The animals were sacrificed, the liver and kidney were harvested, fixed...
Tipo: Journal article
Palavras-chave: Persea Americana; Liver; Kidney; Histopathology.
Ano: 2011
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022011000400053

Action of cobra venom on the renal cortical tissues: electron microscopic studies
Provedor de dados: 79
Autores: RAHMY,T. R.
The effect of intramuscular (IM) injection of a sub-lethal dose of Naja haje cobra venom (0.015 mug/gm body weight) on the ultrastructure of renal cortical tissues of rabbits was studied at different time intervals after envenomation. Succinic dehydrogenase (SDH) enzyme activity was also detected in the renal cortical tubules. Three hours after venom injection, slight changes were seen in visceral cells and glomerular endothelia. The cortical tubular epithelia revealed an increase of lysosomal structures, cytoplasmic vacuolization, and nuclear irregularity. Severe ultrastructural changes were recorded 6 hours after envenomation, including hypertrophied parietal cells, blebbed visceral epithelial cells, and foot process disorganization. Dilated glomerular...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Snake venom; Nephrotoxicity; Kidney; Ultrastructure.
Ano: 2001
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0104-79302001000100007

Renal and vascular effects of Crotalus durissus cumanensis venom and its crotoxin fraction
Provedor de dados: 80
Autores: Pereira,TP; Bezerra de Menezes,RRPP; Torres,AFC; Brito,TS; Batista-Lima,FJ; Vinhote,JFC; Sousa,DF; Ximenes,RM; Toyama,MH; Diz Filho,EBS; Magalhães,PJC; Monteiro,HSA; Martins,AMC.
In this study, we evaluated the actions of Crotalus durissus cumanensis venom (CDCmV), and its crotoxin (Crtx) fraction, on renal and vascular functions in Wistar rats. In isolated perfused kidneys, CDCmV (10 µg/mL) significantly increased the perfusion pressure (PP) from 110.7 ± 2.4 to 125.3 ± 2.8 mmHg after 30 minutes. This effect was accompanied by an increased renal vascular resistance (RVR) from 5.4 ± 0.1 to 6.2 ± 0.2 mmHg/mL.g-1.min-1. We observed decreases in urinary flow (UF) from 0.13 ± 0.01 to 0.05 ± 001 mL.g-1.min-1 and glomerular filtration rate (GFR) from 0.66 ± 0.06 to 0.18 ± 0.02 mL.g-1.min-1. Crtx did not change PP or RVR, but diminished GFR (from 0.65 ± 0.05 to 0.26 ± 003 mL.g-1.min-1) and UF (from 0.11 ± 0.008 to 0.09 ± 0.008...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Kidney; Vascular injuries; Crotalus durissus cumanensis; Crotoxin.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992011000300014

Non-neurotoxic activity of Malayan krait (Bungarus candidus) venom from Thailand
Provedor de dados: 80
Autores: Charoenpitakchai,Mongkon; Wiwatwarayos,Kulachet; Jaisupa,Nattapon; Rusmili,Muhamad Rusdi Ahmad; Mangmool,Supachoke; Hodgson,Wayne C.; Ruangpratheep,Chetana; Chanhome,Lawan; Chaisakul,Janeyuth.
Abstract  Background: Envenoming by kraits (genus Bungarus) is a medically significant issue in South Asia and Southeast Asia. Malayan krait (Bungarus candidus) venom is known to contain highly potent neurotoxins. In recent years, there have been reports on the non-neurotoxic activities of krait venom that include myotoxicity and nephrotoxicity. However, research on such non-neurotoxicity activities of Malayan krait venom is extremely limited. Thus, the aim of the present study was to determine the myotoxic, cytotoxic and nephrotoxic activities of B. candidus venoms from northeastern (BC-NE) and southern (BC-S) Thailand in experimentally envenomed rats.  Methods: Rats were administered Malayan krait (BC-NE or BC-S) venom (50 μg/kg, i.m.) or 0.9% NaCl...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Krait; Bungarus candidus; Myotoxicity; Nephrotoxicity; Venom; Kidney.
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992018000100304

Purification and biological effects of a C-type lectin isolated from Bothrops moojeni
Provedor de dados: 80
Autores: Barbosa,PSF; Martins,AMC; Toyama,MH; Joazeiro,PP; Beriam,LOS; Fonteles,MC; Monteiro,HSA.
Snake venom proteins from the C-type lectin family have very distinct biological activities despite their highly conserved primary structure, which is homologous to the carbohydrate recognition region of true C-type lectins. We purified a lectin-like protein (BmLec) from Bothrops moojeni venom and investigated its effect on platelet aggregation, insulin secretion, antibacterial activity, and isolated kidney cells. The BmLec was purified using two chromatographic steps: affinity chromatography and reverse phase high performance liquid chromatography (HPLC). BmLec showed a dose-dependent platelet aggregation and significantly decreased the bacterial growth rate in approximately 15%. During scanning electron microscopy, the profile of Xanthomonas axonopodis...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Bothrops moojeni; Kidney; Platelet aggregation; Insulin; Antibacterial activity.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992010000300016

Antivenom action on renal effects induced by Thalassophryne nattereri venom
Provedor de dados: 80
Autores: Martins,AMC; Barbosa,PSF; Sousa,DF; Alves,CD; Menezes,DB; Lima,C; Lopes-Ferreira,M; Fonteles,MC; Monteiro,HSA.
Thalassophryne nattereri (niquim) is a venomous fish responsible for numerous accidents involving fishermen in northern and northeastern Brazil. The aim of the present investigation was to evaluate the action of antivenom on renal effects caused by Thalassophryne nattereri venom. Isolated kidneys of Wistar rats were perfused with a previously dialyzed Krebs-Henseleit solution containing 6 g% bovine serum albumin. The antivenom action was studied through perfusion pressure (PP), renal vascular resistance (RVR), urinary flow (UF) and glomerular filtration rate (GFR). The niquim venom (1 µg/mL), the antivenom alone (1 µg/mL) or the venom incubated with antivenom were added to the system 30 minutes after the beginning of each perfusion. Previous works have...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Thalassophryne nattereri; Antivenom; Kidney.
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992009000100011

Polymerase chain reaction in detecting Leishmania sp in symptomatic and asymptomatic seropositive dogs
Provedor de dados: 80
Autores: Soares,M. J. V.; Moraes,J. R. E.; Roselino,A. M. F.
In human and canine renal histological studies of visceral leishmaniasis (VL), the etiological agent is rarely found in situ. The objective of this study was to evaluate PCR in identifying the etiological agent in spleen, liver, lymph node, and kidneys of VL-seropositive dogs. Twenty-five symptomatic (case group) and 15 asymptomatic (control group) VL-seropositive dogs of different breeds, sexes, and ages from Teresina, Piauí State, Brazil, were used. Serologic diagnosis was made by enzyme-linked immunosorbent assay and indirect immunofluorescence test. Animals were subjected to euthanasia and necropsy. Renal fragments were immersed in buffered formaldehyde solution. Spleen, liver, lymph node, and kidney samples were collected and frozen at -70ºC until DNA...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Dogs; Leishmania; PCR; Kidney.
Ano: 2005
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992005000400011

Renal- and calcium-dependent vascular effects of Polybia paulista wasp venom
Provedor de dados: 80
Autores: Vinhote,JFC; Torres,AFC; Dantas,RT; Praciano,TP; Menezes,RRPPB; Sousa,DF; Brito,TS; Lima,FJB; Toyama,MH; Magalhães,PJ; Monteiro,HSA; Martins-Nunes,AMC.
In the present study, the effects of Polybia paulista venom (PPV) on renal and vascular tissues were investigated. Isolated kidneys perfused with PPV (1 and 3 μg/mL) had increased perfusion pressure, renal vascular resistance, urinary flow, and glomerular filtration rate; and reduced sodium tubular transport. Histological evaluation demonstrated deposits of proteins in Bowman's space and tubular lumen, and focal areas of necrosis. The venom promoted a cytotoxic effect on Madin-Darby canine kidney (MDCK) cells. A significant increase in lactic dehydrogenase levels was observed in response to venom exposure. In isolated mesenteric vascular beds, pressure and vascular resistance augmented in a dose-dependent manner. PPV increased the contractility of aortic...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Polybia paulista; Venom; Kidney; Aorta; MDCK.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992011000200011

Feasibility Constraints and Protective Behavior in Efficient Kidney Exchange
Provedor de dados: 31
Autores: Nicolo,   Antonio; Rodriguez Alvarez,   Carmelo.
We propose a model of Kidney-Exchange that incorporates the main European institutional features. We assume that patients do not consider all compatible kidneys homogeneous and patients are endowed with reservation values over the minimal quality of the kidney they may receive. Under feasibility constraints, patients' truthful revelation of reservation values is incompatible with constrained efficiency. In the light of this result, we introduce an alternative behavioral assumption on patients' incentives. Patients choose their revelation strategies as to “protect” themselves from bad outcomes and use a lexicographic refinement of maximin strategies. In this environment, if exchanges are pairwise, then priority rules or rules that maximize a fixed ordering...
Tipo: Working or Discussion Paper
Palavras-chave: Kidney; Matching; Protective Behavior; Institutional and Behavioral Economics; C78; D78.
Ano: 2009
URL: http://purl.umn.edu/50671

Renal Dose Dopamine Mediates the Level of Aquaporin-2 Water Channel (Aqp2) in Broiler Chickens
Provedor de dados: 89
Autores: Chang,Z; Zhang,H; Wu,X; Nabi,F; Rehman,MU; Yuan,X; Mehmood,K; Zhou,D.
ABSTRACT Aquaporin 2 (AQP2) is a small protein located in the collecting tubules of kidneys; it plays an important role in the concentration and production of urine. The aim of this study was to determine the expression level of the AQP2 gene in the kidney of broiler chickens after the administration of renal­dose dopamine. Broiler chickens (25 days-old) were randomly divided into two groups (n=20 per group): intravenous administration of saline solution (control group) or renal-dose dopamine (dopamine group). The expression and localization of the AQP2 gene were evaluated by real-time quantitative polymerase chain reaction (RT-qPCR) and immunohistochemistry (IHC), respectively. The protein level of AQP2 was analyzed by western blot analysis. The dopamine...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: AQP2; Renal dose dopamine; Kidney; Broiler chickens.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-635X2017000300387

Osmoregulatory responses to dietary protein and water intake in the granivorous Zonotrichia capensis (Passerine, Emberizidae)
Provedor de dados: 97
Autores: ALDEA,PATRICIA; SABAT,PABLO.
We studied the osmoregulatory responses of the granivore Zonotrichia capensis, acclimated to high- and low-protein diets as well as two levels of water intake. We tested whether Z. capensis has the ability to modify the proportion of nitrogenous waste in the excreta when protein intake and water intake varies. After 21 days of acclimation, plasma osmolality was not significantly affected by dietary treatment; however, excreta osmolality was higher in the high-protein group compared to the low-protein group. Nitrogenous wastes in Z. capensis are excreted mainly in the form of uric acid. The proportion of kidney devoted to medullary tissue was 40 % higher in dehydrated birds than in hydrated birds. Excreta osmolality was higher in dehydrated birds, and in...
Tipo: Journal article
Palavras-chave: Granivory; Kidney; Nitrogenous waste; Osmoregulation; Passerines.
Ano: 2007
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-078X2007000400006

Diabetic nephropathy in dogs: literature review
Provedor de dados: 195
Autores: Martorelli, Cínthia Ribas; Kogika, Márcia Mery; Caragelasco, Douglas Segalla.
Diabetes mellitus caused by insulin deficiency and chronic hyperglycemia usually presents complications including cataract, retinopathy, recurrent infections and ketoacidosis. Chronic hyperglycemia can cause long-term complications such as diabetic nephropathy. In humans, diabetic nephropathy is characterized mainly by glomerular injury and usually it is associated with systemic hypertension. The mechanisms proposed for the pathogenesis of diabetic nephropathy could be glomerular injury, as well as renal tubular damage. However, there are few studies analyzing the relationship between diabetes mellitus and kidney damage in dogs. The objective of this review is to clarify the pathophysiological mechanisms of diabetic nephropathy and to analyze the available...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Canine; Kidney; Hyperglycemia; Diabetes mellitus canino; Rim; Hiperglicemia; Diabetes mellitus.
Ano: 2018
URL: http://www.revistamvez-crmvsp.com.br/index.php/recmvz/article/view/37712

New records of Leptospira spp. in wild marsupials and a rodent in the eastern Brazilian Amazon through PCR detection
Provedor de dados: 36
Autores: SOUZA ROCHA,Katarine de; SCHUPP DE SENA MESQUITA,Gleiciane; SILVA FERREIRA,Maeli Fernanda; LEITE BARROS,Flávia de Nazaré; MACEDO,Renata Cecília Soares de Lima; ARAÚJO SARAIVA,Elane de; MENDES-OLIVEIRA,Ana Cristina; DUARTE CERQUEIRA,Valíria; SCOFIELD,Alessandra; GOES CAVALCANTE,Gustavo; ABEL,Isis; GUIMARÃES DE MORAES,Carla Cristina.
ABSTRACT We analyzed the presence of Leptospira spp. in liver and kidney tissue of wild marsupials and rodents trapped in a periurban forest in the eastern Brazilian Amazon. We examined 25 individuals of four marsupial and seven rodent species for the presence of the 16S rRNA gene of Leptospira in the DNA extracted from 47 liver and kidney tissue samples using PCR. We detected positive samples in 12% (3/25) of the individuals, in kidney fragments of two marsupial species (Didelphis marsupialis and Marmosops pinheiroi) and in a liver fragment of one rodent species (Echimys chrysurus). These are the first records of Leptospira spp. in M. pinheiroi and E. chrysurus and it is the first molecular survey of marsupials and rodents in the Brazilian Amazon.
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Didelphimorphia; Rodentia; Live traps; Kidney; Liver; 16S rRNA.
Ano: 2020
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0044-59672020000400305

Haematology and melanoma crophage centers of Nile tilapia fed supplemented diet with propolis
Provedor de dados: 3
Autores: Ledic-Neto, Jerko; Universidade Federal de Santa Catarina; Dotta, Geovana; Universidade Federal de Santa Catarina; Garcia, Patrícia; Universidade Federal de Santa Catarina; Brum, Aline; Universidade Federal de Santa Catarina; Gonçalves, Eduardo Luis Tavares; Universidade Federal de Santa Catarina; Martins, Maurício Laterça; Universidade Federal de Santa Catarina.
The objective of this study was to investigate the influence of dietary supplementation with propolis on hematology and number and area of melanomacrophage centers in spleen and kidney of tilapia. After acclimation, fish (24.7 ± 7.4 gmean weight) were distributed in 6 tanks 100 L, 6 fish per tank, in triplicate, at a temperature 24.0 ± 2.8oC, with two treatments: Fish fed 2% propolis supplemented diet and fish fed non-supplemented diet. To monitor the evolution of the effects, two samples were collected: half of the fish from each treatment were used after 15 days and the other half after 21, composing two feeding times. After each feeding time, blood, spleen and kidney were collected. After twenty one days feeding on 2% propolis supplemented diet, fish...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: 5.06.03.00-0 fish; Blood; Kidney; Spleen; Hemosiderin Aquicultura.
Ano: 2014
URL: http://periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/22024

Variations in human renal arteries - doi: 10.4025/actascibiolsci.v35i2.11178
Provedor de dados: 3
Autores: Soares, Tania Regina Santos; Universidade Estadual de Maringá; Ferraz, Juliana Soares; Faculdade Ingá; Dartibale, Camila Buziquia; Universidade Estadual de Maringá; Oliveira, Inandiara Rafaella Marco; Faculdade Ingá.
Kidneys are especially irrigated by a pair of arteries originated from the aorta artery. The presence of additional renal arteries is the most frequent variation in this vascularization, an aspect important to be known in renal surgeries and radiological procedures (SAMPAIO; PASSOS, 1992). This study aimed to observe the prevalence of numeric variation and the origin of the additional renal artery. For this purpose, 24 cadavers and 26 blocks were used; each block contained the kidneys and their respective arteries and veins, the abdominal aorta and inferior vena cava, taken from adults of different ethnicity and genders, from the Department of Morphological Science, State University of Maringá (DCM/UEM) and Laboratory of Anatomy, Ingá Faculty (UNINGÁ)....
Tipo: Estudo morfológico
Palavras-chave: 2.06.04.01-7 additional; Multiple; Anatomy; Vascularization; Kidney; Vessels Anatomia humana.
Ano: 2013
URL: http://periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/11178

The impact of long-term consumption of diets enriched with olive, cottonseed or sesame oils on kidney morphology: A stereological study
Provedor de dados: 42
Autores: HASSANZADEH-TAHERI,MOHAMMADMEHDI; HASSANZADEH-TAHERI,MAHSA; JAHANI,FARNAZ; ERFANIAN,ZAHRA; MOODI,HESAM; HOSSEINI,MEHRAN.
Abstract: To date, most of studies have only focused on metabolic effects of dietary oils while recent evidence proposes that they can influence kidneys structure. Therefore, the aim of this study was to evaluate the impact of long-term consumption of olive, cottonseed and sesame oils on renal morphology in rats. 70 male Wistar rats randomly assigned into seven equal groups and treated with standard diet (control), the standard diet enriched with 10% or 20% (W/W) of either olive oil (OLI10%, OLI20%), cottonseed oil (COT10%, COT20%) or sesame oil (SES10%, SES20%) for 5 months. Quantitative features of the kidney including kidney and cortex volumes and the number of glomeruli were analyzed stereologically. Moreover, kidney sections histologically were...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Cottonseed oil; Histopathology; Kidney; Olive oil; Sesame oil; Stereology.
Ano: 2019
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652019000300702

Effects of Tityus stigmurus (Thorell 1876) (Scorpiones: Buthidae) venom in isolated perfused rat kidneys
Provedor de dados: 42
Autores: SILVA,NATHALIA A.; ALBUQUERQUE,CLEIDE M.R.; MARINHO,ALINE D.; JORGE,ROBERTA J.B.; SILVA NETO,ANTONIO G.; MONTEIRO,HELENA S.A.; SILVA,TÚLIO D.; SILVA,MÁRCIA V.; CORREIA,MARIA TEREZA S.; PEREIRA,TICIANA P.; MARTINS,ALICE M.C.; MENEZES,DALGIMAR B.; XIMENES,RAFAEL M.; MARTINS,RENÉ D.
ABSTRACT Scorpions belonging to the Tityus genus are of medical interest in Brazil. Among them, Tityus stigmurus is the main scorpion responsible for stings in the Northeast region. After a sting, the scorpion venom distributes rapidly to the organs, reaching the kidneys quickly. However, there are few studies concerning the renal pathophysiology of scorpion poisoning. In this study, we evaluated the effects of T. stigmurus venom (TsV) on renal parameters in isolated rat kidneys. Wistar rats (n = 6), weighing 250-300 g, were perfused with Krebs-Henseleit solution containing 6 g/100 mL bovine serum albumin. TsV at 0.3 and 1.0 μg/mL was tested, and the effects on perfusion pressure (PP), renal vascular resistance (RVR), urinary flow (UF), glomerular...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: 2D-PAGE; Kidney; MDCK; Venom; Tityus stigmurus.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652016000200665

The Cystic Fibrosis Transmembrane Regulator (CFTR) in the kidney
Provedor de dados: 42
Autores: MORALES,MARCELO M.; FALKENSTEIN,DORIS; LOPES,ANÍBAL GIL.
The cystic fibrosis transmembrane regulator (CFTR) is a Cl- channel. Mutations of this transporter lead to a defect of chloride secretion by epithelial cells causing the Cystic Fibrosis disease (CF). In spite of the high expression of CFTR in the kidney, patients with CF do not show major renal dysfunction, but it is known that both the urinary excretion of drugs and the renal capacity to concentrate and dilute urine is deficient. CFTR mRNA is expressed in all nephron segments and its protein is involved with chloride secretion in the distal tubule, and the principal cells of the cortical (CCD) and medullary (IMCD) collecting ducts. Several studies have demonstrated that CFTR does not only transport Cl- but also secretes ATP and, thus, controls other...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: CFTR; Kidney; Nephron; Chloride channel.
Ano: 2000
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652000000300013

Multiple congenital defects in a newborn foal
Provedor de dados: 45
Autores: Silva,J.F.; Serakides,R.; França,S.A.; Boeloni,J.N.; Ocarino,N.M.
A case of multiple congenital defects in a newborn foal is reported. The animal showed hypoplasia of the left pelvic limb bones, uterus unicornis, congenital diaphragmatic hernia, and unilateral renal and ureteral agenesis. This report includes the macroscopic and microscopic lesions observed in the case.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Foal; Congenital defects; Uterus; Kidney; Diaphragm.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352014000601671

Parasitism by Paratanaisia bragai (Digenea, Eucotylidae) in commom waxbill (Estrilda astrild)
Provedor de dados: 45
Autores: Tavela,A.O.; Carretta Junior,M.; Oliveira,A.R.; Carneiro,F.T.; Silva,V.H.D.; Braga,F.R.; Peixoto,J.V.; Carvalho,G.D.; Araújo,J.V.; Paula,T.A.R.
O trematodeo digenético Paratanaisia bragai é descrito como parasito dos túbulos coletores renais e ureteres de aves. Esse helminto é usualmente pouco patogênico para a maioria dos hospedeiros; porém, em altas cargas parasitárias e em animais mais suscetíveis, pode causar sérios danos que resultam em apatia, perda de peso, desidratação e até mesmo a morte. O presente trabalho objetivou relatar pela primeira vez o trematoide P. bragai parasitando os rins de um passeriforme da espécie Estrilda astrild, conhecido popularmente como bico-de-lacre, de distribuição cosmopolita. A partir da análise histopatológica dos rins da ave, observou-se a presença dos vermes adultos e de ovos, grande dilatação dos ductos coletores renais, destruição e achatamento das células...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Kidney; Trematode; Parasitism; Passeriformes.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352014000401276

Echobiometrics kidney and renal artery triplex doppler of canine fetuses
Provedor de dados: 45
Autores: Feliciano,M.A.R.; Cardilli,D.J.; Nepomuceno,A.C.; Crivalero,R.M.; Silva,M.A.M.; Coutinho,L.N.; Oliveira,M.E.F.; Vicente,W.R.R.
The aim of this study was to assess the sogographic parameters and biometry of canine fetal kidneys using the B mode, and to determinate the vascular index of the fetal renal arteries using the Doppler Triplex. Twenty four Shi-tzu and Pug, weighting between 4 and 10kg, aging between 4 and 6 years old were evaluated. The B mode, the fetal renal echobiometry and regularity of the renal surface, echotexture and cortex:medular ratio were evaluated during the 5th, 6th, 7th and 8th weeks of pregnancy. At the same time point of the B mode evaluation, the Doppler Triplex was carried out to assess the sistolic peak velocity (SPV), end diastolic velocity (EDV), vascular resistive (RI) and pulsatility index (PI). B mode revealed no fetal renal abnormalities and...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Canine; Kidney; Fetuses; B-mode ultrasound; Vascular index.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352014000200018

Variable number tandem repeats in the promoter region of prostacyclin synthase gene in choline deficient rats
Provedor de dados: 47
Autores: Denninghoff,Valeria C.; Ossani,Georgina P.; Uceda,Ana M.; Avagnina,Maria A.; Elsner,Boris; Monserrat,Alberto J.
Weanling Sprague-Dawley rats were fed on a choline-deficient diet with hydrogenated vegetable oil and corn oil as lipids develop acute renal failure. Pathogenesis of the latter is controversial and an ischemic mechanism has been proposed. Arachidonic acid derivatives are involved in the regulation of vascular tonus. Vasospasm could be due to an increase in tromboxane A2-mediated vasoconstriction or to a decrease in prostacyclin-induced vasodilatation. Enzymes involved in the synthesis of both compounds are tromboxane A2- and prostacyclin-synthase respectively. The aim of this study was to identify the variable number tandem repeats (VNTR) in the promoter region of prostacyclin synthase gene and verify if there exists a relationship between the occurrence...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: VNTR; Prostacyclin synthase gene; Kidney.
Ano: 2010
URL: http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S0327-95452010000200002

Protective effect of aqueous suspension of dried latex of Calotropis procera against oxidative stress and renal damage in diabetic rats
Provedor de dados: 47
Autores: Kumar,Vijay L.; Padhy,Biswa M.
Calotropis species have been used in the traditional medicinal system for the treatment of diseases of the liver and abdomen. In view of the antioxidant and anti-hyperglycemic properties of an aqueous suspension obtained from the dried latex of Calotropis procera, the present study was carried out to evaluate its efficacy in affording protection against alloxan induced changes in rat kidney. A single intraperitoneal injection of alloxan (150 mg/kg) in rats produced hyperglycemia within 3 days and altered kidney functions over a period of 90 days. Daily oral administration of the aqueous suspension (100 and 400 mg/kg) in diabetic rats produced anti-hyperglycemic effect that was comparable to that of glibenclamide (10 mg/kg). Unlike glibenclamide, the...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Diabetes; Kidney; Anti-oxidant; Anti-hyperglycemic.
Ano: 2011
URL: http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S0327-95452011000300001

Structure of the kidney of Bufo arenarum: Intermediate segment, distal tubule and collecting tubule
Provedor de dados: 47
Autores: Farías,Alejandro; Hermida,Gladys Noemí; Fiorito,Luisa Eleonora.
The ultrastructure of the intermediate segment (IS), distal tubule and collecting tubule (CT) of the south american toad Bufo arenarum, was studied by light and transmission electron microscopy. The IS is composed of cubical ciliated cells which propel the urine along the renal tubule. The distal tubule is divided into two portions: the early distal tubule (EDT) and the late distal tubule (LDT). The EDT is characterized by only one type of cells with well developed basolateral interdigitations and numerous elongated mitochondria, which are oriented normal to the basal surface. The "macula densa - like" is a specialized zone of the EDT in contact with the vascular pole, where cells are more tightly packed than in the rest of the tubule. The LDT shows two...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Amphibia; Kidney; Ultrastructure; Renal tubules.
Ano: 2003
URL: http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S0327-95452003000100003

p53-Rb signaling pathway is involved in tubular cell senescence in renal ischemia/reperfusion injury
Provedor de dados: 47
Autores: Li,Kailong; Du,Xiaolan; He,Yani; Zhao,Lin; Yang,Jvrong; Song,Ruihua; Chen,Lin.
Objective: To investigate the course of tubular cell senescence and expressions of p53, p21, and Rb during the late phase of ischemia/reperfusion (IRI) in the kidney, and assess the effects of the p53-Rb pathway on tubular cell senescence. Methods: Experimental models of unilateral renal IRI were used in p53(+/+) and p53(-/-) mice. Histological changes at the tubular level, progress of cell senescence, and the expression of Rb, p21, and/or p53 proteins in tubular cells were studied at different moments in time after IRI. Results: Chronic tubulointerstitial fibrosis was much more severe and widely distributed in IRI kidneys of p53(+/+) mice in later stages than in earlier stages. Senescent tubular cells were significantly increased at 3 and 6 months after...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Cell senescence; Cell cycle regulatory protein; Ischemia/reperfusion injury; Kidney.
Ano: 2007
URL: http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S0327-95452007000200003

Tissue mRNA expression in rat of newly described matrix metalloproteinases
Provedor de dados: 48
Autores: BERNAL,FABIÁN; HARTUNG,HANS-PETER; KIESEIER,BERND C.
Matrix metalloproteinases (MMPs) comprise a large group of endoproteinases that degrade all protein components of the extracellular matrix. Functionally, MMPs contribute to several different physiological as well as pathological conditions. The number of newly described MMPs has increased in recent years, although current knowledge about their expression pattern in various tissues remains incomplete. Here we analyzed the relative mRNA expression of the most recently described MMPs _ MT5-MMP (MMP-24), MT6-MMP (MMP-25), MMP-27 and epilysin (MMP-28) _ in a broad selection of rat tissues using real time-PCR. MMP-24 mRNA was found to be widely expressed with predominance in the central nervous system. MMP-25 mRNA, in contrast, exhibited peak expression levels...
Tipo: Journal article
Palavras-chave: Bone; CNS; Epilysin; Kidney; MT5-MMP; MT6-MMP; Testis.
Ano: 2005
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602005000200016

Alpinia oxyphylla Miq. extract changes miRNA expression profiles in db-/db- mouse kidney
Provedor de dados: 48
Autores: Du,Guankui; Xiao,Man; Zhang,Xuezi; Wen,Maoyu; Pang,Chi; Jiang,Shangfei; Sang,Shenggang; Xie,Yiqiang.
Abstract  Background A number of dysregulated miRNAs have been identified and are proposed to have significant roles in the pathogenesis of type 2 diabetes mellitus or renal pathology. Alpinia oxyphylla has shown significant anti-inflammatory properties and play an anti-diabetes role. The objective of this study was to detect the alteration of miRNAs underlying the anti-diabetes effects of A. oxyphylla extract (AOE) in a type II diabetic animal model (C57BIKsj db-/db-).  Results Treatment with AOE for 8 weeks led to lower concentrations of blood glucose, urine albumin, and urine creatinine. 17 and 13 miRNAs were statistically identified as differentially regulated in the DB/DB and db-/db- AOE mice, respectively, compared to the untreated db-/db- mice. Of...
Tipo: Journal article
Palavras-chave: MiRNA; Db-/db- mice; Alpinia oxyphylla Miq; Kidney; Diabetic nephropathy.
Ano: 2017
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602017000100206

Lycopene Protects the Diabetic Rat Kidney Against Oxidative Stress-mediated Oxidative Damage Induced by Furan
Provedor de dados: 52
Autores: Pandir,Dilek; Unal,Betul; Bas,Hatice.
Furan is a food and environmental contaminant and a potent carcinogen in animals. Lycopene is one dietary carotenoid found in fruits such as tomato, watermelon and grapefruit. The present study was designed to explore the protective effect of lycopene against furan-induced oxidative damage in streptozotocin (STZ)-induced diabetic rat kidney. At the end of the experimental period (28 days), we found that lycopene markedly decreased the malondialdehide (MDA) levels in the kidney, urea, uric acid and creatinine levels in the serum of furan-treated rats. The increase of histopathology in the kidney of furan-treated rats were effectively suppressed by lycopene. Furthermore, lycopene markedly restored superoxide dismutase (SOD), catalase (CAT), glutathione...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Furan; Lycopene; Kidney; Oxidative stress; Diabetes.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132016000100314

Nephroprotective and anti-inflammatory effects of aqueous extract of Melissa officinalis L. on acetaminophen-induced and pleurisy-induced lesions in rats
Provedor de dados: 52
Autores: Müzell,Denise Pereira; Lunardelli,Adroaldo; Leite,Carlos Eduardo; Fagundes,Rodrigo Medeiros; Saciura,Vasyl Custódio; Reichel,Carlos Luiz; Oliveira,Jarbas Rodrigues de; Astarita,Leandro Vieira.
This study assessed the bioactive properties of an aqueous extract of M. officinalis for its anti-inflammatory activity and its protection against hepatic and renal lesions induced by acetaminophen (APAP). Animals pre-treated with the crude extract in pleurisy induced by carrageenan showed a reduction in the amounts of exudate, in the numbers of leukocytes and polymorphonuclear cells. Intragastric administration of the extract for seven days prior to the APAP-induced lesion showed no protective effect on the liver. The treatment with the extract induced an increase of serum aspartate aminotransferase, indicating a rise of toxicity. Contrarily, the same treatment reduced the APAP induced lesion in kidney, with respect to ν-glutamyltransferase. The results...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Acetaminophen; Melissa officinalis; Pleurisy; Anti-inflammatory; Kidney; Liver.
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132013000300006

Histopathologic changes in the kidney tissue of Prochilodus lineatus Valenciennes, 1836 (Characiformes, Prochilodontidae) induced by sublethal concentration of Trichlorfon exposure
Provedor de dados: 52
Autores: Veiga,Marcelo Leite da; Rodrigues,Edson de Lara; Pacheco,Fabio Juliano; Ranzani-Paiva,Maria José Tavares.
Studies were carried out to analyse the kidney histopathological alterations of "curimbatá", Prochilodus lineatus, were analyzed. An acute bioassay was made by the water contamination with 0.2muml/l of Dipterex 500 (Trichlorfon). The kidney tissue collected after 24 hours of exposure showed an enlargement of intercapsular space with glomerular atrophy, hypertrophy of the kidney tube cells, with small granules on its cytoplasm and little nuclear alteration. Blood overflowing from capillaries with pyknotic nuclei and vacuoles in the cytoplasm it was also noticed. After 48 hours, the kidney tissue showed glomerular expansion, impossibility to visualize the intercapsular space as well as cytoplasm limit of many cells. The parietal capsular epithelium and the...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Kidney; Prochilodus lineatus; Curimbatá; Trichlorfon.
Ano: 2002
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132002000200007

Alkaline phosphatase activity in plasma and liver of rats submitted to chronic exposure to fluoride
Provedor de dados: 52
Autores: Fernandes,Mileni da Silva; Iano,Flávia Godoy; Rocia,Vivian; Yanai,Marcela Mitsuko; Leite,Aline de Lima; Furlani,Tatiana Almeida; Buzalaf,Marília Afonso Rabelo; Oliveira,Rodrigo Cardoso de.
The aim of this study was to compare the effect of fluoride (F) on alkaline phosphatase activity in the liver and plasma of the rats. Four groups of male Wistar rats (n=6), which received drinking water containing 5, 15 or 50 ppm F or deionized water (control) throughout the experiment were included in the study. The animals were euthanized and had their tissues and blood plasma collected for the analysis of fluoride and alkaline phosphatase. There was an increase in F concentration in most tissues in the animals treated with higher F concentrations, except for the heart. The alkaline phosphatase assay showed an increase in the activity in the liver and blood plasma of the animals treated with fluoride concentrations of 15 and 50 ppm (p&lt;0.05). This...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Alkaline phosphatase; Fluoride; Liver; Kidney.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132011000600014

Expression of Ghrelin and GHSR-1a in Long Term Diabetic Rat's Kidney
Provedor de dados: 52
Autores: Yildirim,Aysegul Burcin; Karabulut,Derya; Dundar,Munis; Ulusoy,Hasan Basri; Sonmez,Mehmet Fatih.
The aim of this work was to study the relative ghrelin and growth hormone secretagogue receptor (GHS-R)1a gene expression in the kidney of long-term diabetic rats. Forty male Wistar albino rats were divided into four groups: C- control group, DI- one month diabetic rats group, DII- two months diabetic rats group, and DIII- three months diabetic rats group. Diabetes was induced by streptozotocin STZ (40mg/kg i.p). The rats were decapitated under ketamine anesthesia and their kidney tissues were removed. Tissue GHS-R mRNA levels, ghrelin expression, and histopathological damage scores were compared. Dilatation in the distal tubules, epithelial desquamation into the lumen of the tubules and transparent tubules showing glycogen vacuolation were observed in all...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Diabetes mellitus; Ghrelin; GHSR-1a; Kidney; Immunohistochemistry; RT-PCR.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132016000100300

Targeted preemptive therapy according to perceived risk of CMV infection after kidney transplantation
Provedor de dados: 55
Autores: Pinto,Cahue Henrique; Tedesco-Silva Jr,Helio; Felipe,Claudia Rosso; Ferreira,Alexandra Nicolau; Cristelli,Marina; Viana,Laila Almeida; Aguiar,Wilson; Medina-Pestana,José.
ABSTRACT  Background: The identification of the best strategy to manage cytomegalovirus infection is hampered by uncertainties regarding the risk/benefit ratios of universal prophylaxis versus preemptive therapy, the impact of indirect cytomegalovirus effects and the associated costs. This study investigated the efficacy and safety of targeted preemptive therapy according to perceived risk of cytomegalovirus infection after kidney transplantation.  Methods: 144 adult kidney transplant recipients were enrolled in this 12-month study. None received cytomegalovirus pharmacological prophylaxis. Only high risk patients (positive donor/negative recipient (D+/R−), use of induction therapy with antithymocyte globulin, treatment of rejection) received preemptive...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Cytomegalovirus; Kidney; Transplant; Preemptive therapy.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000600576

Renal involvement in leprosy: retrospective analysis of 461 cases in Brazil
Provedor de dados: 55
Autores: Silva Júnior,Geraldo Bezerra da; Daher,Elizabeth De Francesco.
BACKGROUND: Renal lesions in leprosy have been extensively described, including amyloidosis, glomerulonephritis, nephrosclerosis, tubulointerstitial nephritis and granulomas. MATERIAL AND METHODS: A retrospective study was designed to detect renal function abnormalities in 461 leprosy patients, without any co-morbidity, seen in a university hospital in northeast Brazil. The laboratory test results concerning renal function were examined in the patients' medical records. RESULTS: The mean age was 39 ± 18 years and 217 (47%) were male. The mean duration of disease was 21 ± 38 months. Levels of creatinine above 1.4mg/dL had been detected in 40 patients (8.6%). The levels of creatinine and urea were higher in lepromatous leprosy patients. Proteinuria,...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Leprosy; Kidney; Renal abnormalities; Renal failure.
Ano: 2006
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702006000200007

Role of sympathetic nervous system and neuropeptides in obesity hypertension
Provedor de dados: 56
Autores: Hall,J.E.; Brands,M.W.; Hildebrandt,D.A.; Kuo,J.; Fitzgerald,S.
Obesity is the most common cause of human essential hypertension in most industrialized countries. Although the precise mechanisms of obesity hypertension are not fully understood, considerable evidence suggests that excess renal sodium reabsorption and a hypertensive shift of pressure natriuresis play a major role. Sympathetic activation appears to mediate at least part of the obesity-induced sodium retention and hypertension since adrenergic blockade or renal denervation markedly attenuates these changes. Recent observations suggest that leptin and its multiple interactions with neuropeptides in the hypothalamus may link excess weight gain with increased sympathetic activity. Leptin is produced mainly in adipocytes and is believed to regulate energy...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Obesity; Leptin; Angiotensin; Kidney; Sodium excretion.
Ano: 2000
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000000600001

Characterization of renin mRNA expression and enzyme activity in rat and mouse mesangial cells
Provedor de dados: 56
Autores: Andrade,A.Q.; Casarini,D.E.; Schor,N.; Boim,M.A.
Renin is an enzyme involved in the stepwise generation of angiotensin II. Juxtaglomerular cells are the main source of plasma renin, but renin activity has been detected in other cell types. In the present study we evaluated the presence of renin mRNA in adult male Wistar rat and mouse (C-57 Black/6) mesangial cells (MC) and their ability to process, store and release both the active and inactive forms of the enzyme. Active renin and total renin content obtained after trypsin treatment were estimated by angiotensinogen consumption analyzed by SDS-PAGE electrophoresis and quantified by angiotensin I generation by HPLC. Renin mRNA, detected by RT-PCR, was present in both rat and mouse MC under basal conditions. Active renin was significantly higher...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Renin; Prorenin; Mesangial cell; Kidney.
Ano: 2002
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2002000100003

Effects of microcystin-LR in isolated perfused rat kidney
Provedor de dados: 56
Autores: Nobre,A.C.L.; Jorge,M.C.M.; Menezes,D.B.; Fonteles,M.C.; Monteiro,H.S.A.
Microcystin is a hepatotoxic peptide which inhibits protein phosphatase types 1 and 2A. The objective of the present study was to evaluate the physiopathologic effects of microcystin-LR in isolated perfused rat kidney. Adult Wistar rats (N = 5) of both sexes (240-280 g) were utilized. Microcystin-LR (1 µg/ml) was perfused over a period of 120 min, during which samples of urine and perfusate were collected at 10-min intervals to determine the levels of inulin, sodium, potassium and osmolality. We observed a significant increase in urinary flow with a peak effect at 90 min (control (C) = 0.20 ± 0.01 and treated (T) = 0.32 ± 0.01 ml g-1 min-1, P&amp;lt;0.05). At 90 min there was a significant increase in perfusate pressure (C = 129.7 ± 4.81 and T = 175.0 ±...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Microcystin-LR; Kidney; Perfused kidney.
Ano: 1999
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999000800008

Relationship between the actions of atrial natriuretic peptide (ANP), guanylin and uroguanylin on the isolated kidney
Provedor de dados: 56
Autores: Santos-Neto,M.S.; Carvalho,A.F.; Forte,L.R.; Fonteles,M.C.
Guanylin and uroguanylin are peptides that bind to and activate guanylate cyclase C and control salt and water transport in many epithelia in vertebrates, mimicking the action of several heat-stable bacteria enterotoxins. In the kidney, both of them have well-documented natriuretic and kaliuretic effects. Since atrial natriuretic peptide (ANP) also has a natriuretic effect mediated by cGMP, experiments were designed in the isolated perfused rat kidney to identify possible synergisms between ANP, guanylin and uroguanylin. Inulin was added to the perfusate and glomerular filtration rate (GFR) was determined at 10-min intervals. Sodium was also determined. Electrolyte dynamics were measured by the clearance formula. Guanylin (0.5 µg/ml, N = 12) or uroguanylin...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: ANP; Guanylin; Uroguanylin; Kidney; Natriuresis; CGMP.
Ano: 1999
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999000800012

Effect of antibodies to intercellular adhesion molecule type 1 on the protection of distant organs during reperfusion syndrome in rats
Provedor de dados: 56
Autores: Souza-Moraes,M.R.; David-Filho,R.; Baptista-Silva,J.C.C.; Ullian,M.; Franco,M.F.; Gabriel Jr.,A.; Smith,B.; Burihan,E.
We investigated kidney and lung alterations caused by intercellular adhesion molecule type 1 (ICAM-1) blockade after ischemia and reperfusion of hind limb skeletal muscles. Rats were submitted to ligature of the infrarenal aorta for 6 h. The animals were randomized into three groups of 6 rats each: group I, sacrificed after ischemia; group II, reperfusion for 24 h, and group III, reperfusion for 24 h after receiving monoclonal anti-ICAM-1 antibodies. At the end of the experiment, blood samples were collected for creatinine, lactate dehydrogenase, creatine phosphokinase, potassium, pH and leukocyte counts. Samples were taken from the muscles of the hind limbs and from the kidneys and lungs for histological analysis and measurement of the neutrophil...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: ICAM-1; Neutrophil; Myeloperoxidase; Kidney; Lung; Reperfusion.
Ano: 2003
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2003000500007

Dermatan sulfate reduces monocyte chemoattractant protein 1 and TGF-β production, as well as macrophage recruitment and myofibroblast accumulation in mice with unilateral ureteral obstruction
Provedor de dados: 56
Autores: Belmiro,C.L.R.; Gonçalves,R.G.; Kozlowski,E.O.; Werneck,A.F.; Takyia,C.M.; Leite-Jr.,M.; Pavão,M.S.G.
Selectins play an essential role in most inflammatory reactions, mediating the initial leukocyte-rolling event on activated endothelium. Heparin and dermatan sulfate (DS) bind and block P- and L-selectin function in vitro. Recently, we reported that subcutaneous administration of DS inhibits colon inflammation in rats by reducing macrophage and T-cell recruitment and macrophage activation. In the present study, we examined the effect of porcine intestinal mucosa DS on renal inflammation and fibrosis in mice after unilateral ureteral obstruction (UUO). Twenty-four adult male Swiss mice weighing 20-25 g were divided into 4 groups: group C (N = 6) was not subjected to any surgical manipulation; group SH (N = 6) was subjected to surgical manipulation but...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Glycosaminoglycans; Dermatan sulfate; Kidney; Inflammation.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2011000700003

Renal actions of angiotensin-(1-7)
Provedor de dados: 56
The heptapeptide angiotensin-(1-7) is considered to be a biologically active endproduct of the renin-angiotensin system. This angiotensin, which is devoid of the most known actions of angiotensin II such as induction of drinking behavior and vasoconstriction, has several selective effects in the brain and periphery. In the present article we briefly review recent evidence for a physiological role of angiotensin-(1-7) in the control of hydroelectrolyte balance
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Angiotensin antagonists; Angiotensin II; Hydroelectrolyte balance; Renin-angiotensin system; Kidney; Water transport.
Ano: 1997
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1997000400012

Detection of cytomegalovirus infections by PCR in renal transplant patients
Provedor de dados: 56
Autores: Costa,S.C.B.; Miranda,S.R.P.; Alves,G.; Rossi,C.L.; Figueiredo,L.T.M.; Costa,F.F.
Cytomegalovirus (CMV) is the single most important infectious agent affecting recipients of organ transplants. To evaluate the incidence and the clinical importance of CMV infection in renal transplants in Brazil, 37 patients submitted to renal allograft transplants were tested periodically for the presence of cytomegalovirus DNA in urine using the polymerase chain reaction (PCR), and for the presence of IgM and IgG antibodies against CMV by enzyme-linked immunosorbent assay (ELISA) and indirect immunofluorescence (IIF). The PCR-amplified products were detected by gel electrophoresis and confirmed by dot-blot hybridization with oligonucleotide probes. Thirty-two of the 37 patients (86.4%) were positive by at least one of the three methods. In six patients,...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Transplantation; CMV; PCR; Kidney.
Ano: 1999
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999000800004

Nitric oxide synthase blockade and body fluid volumes
Provedor de dados: 56
Autores: Balaszczuk,A.M.; Tomat,A.; Bellucci,S.; Fellet,A.; Arranz,C.
The influence of chronic nitric oxide synthase inhibition with N G-nitro-L-arginine methyl ester (L-NAME) on body fluid distribution was studied in male Wistar rats weighing 260-340 g. Extracellular, interstitial and intracellular spaces, as well as plasma volume were measured after a three-week treatment with L-NAME (~70 mg/kg per 24 h in drinking water). An increase in extracellular space (16.1 ± 1.1 vs 13.7 ± 0.6 ml/100 g in control group, N = 12, P&lt;0.01), interstitial space (14.0 ± 0.9 vs 9.7 ± 0.6 ml/100 g in control group, P&lt;0.001) and total water (68.7 ± 3.9 vs 59.0 ± 2.9 ml/100 g, P&lt;0.001) was observed in the L-NAME group (N = 8). Plasma volume was lower in L-NAME-treated rats (2.8 ± 0.2 ml/100 g) than in the control group (3.6 ± 0.1...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Nitric oxide; Kidney; Heart; Body fluid; Hypertension; Extracellular space; Intracellular space; L-NAME.
Ano: 2002
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2002000100019

Kallikrein-like amidase activity in renal ischemia and reperfusion
Provedor de dados: 56
Autores: Carattino,M.D.; Cueva,F.; Fonovich-de-Schroeder,T.M.; Zuccollo,A.
We assessed a kallikrein-like amidase activity probably related to the kallikrein-kinin system, as well as the participation of leukocyte infiltration in renal ischemia and reperfusion. Male C57BL/KSJmdb mice were subjected to 20 or 60 min of ischemia and to different periods of reperfusion. A control group consisted of sham-operated mice, under similar conditions, except for ischemia induction. Kallikrein-like amidase activity, Evans blue extravasation and myeloperoxidase activity were measured in kidney homogenates, previously perfused with 0.9% NaCl. Plasma creatinine concentration increased only in the 60-min ischemic group. After 20 min of ischemia and 1 or 24 h of reperfusion, no change in kallikrein-like amidase activity or Evans blue extravasation...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Kidney; Ischemia-reperfusion; Kallikrein; Vascular permeability; Leukocyte infiltration.
Ano: 2000
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000000500015

Role of nitric oxide and prostaglandin in the maintenance of cortical and renal medullary blood flow
Provedor de dados: 56
Autores: Gomez,S.I; Strick,D.M.; Romero,J.C.
This study was undertaken in anesthetized dogs to evaluate the relative participation of prostaglandins (PGs) and nitric oxide (NO) in the maintenance of total renal blood flow (TRBF), and renal medullary blood flow (RMBF). It was hypothesized that the inhibition of NO should impair cortical and medullary circulation because of the synthesis of this compound in the endothelial cells of these two territories. In contrast, under normal conditions of perfusion pressure PG synthesis is confined to the renal medulla. Hence PG inhibition should predominantly impair the medullary circulation. The initial administration of 25 µM kg-1 min-1 NG-nitro-L-arginine methyl ester produced a significant 26% decrease in TRBF and a concomitant 34% fall in RMBF, while the...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Kidney; NG-nitro-L-arginine methyl ester; Meclofenamate; Renal circulation.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2008000200014

Glomerular filtration is reduced by high tidal volume ventilation in an in vivo healthy rat model
Provedor de dados: 56
Autores: Luque,A.; Shimizu,M.H.M.; Andrade,L.; Sanches,T.R.; Seguro,A.C.
Mechanical ventilation has been associated with organ failure in patients with acute respiratory distress syndrome. The present study examines the effects of tidal volume (V T) on renal function using two V T values (8 and 27 mL/kg) in anesthetized, paralyzed and mechanically ventilated male Wistar rats. Animals were randomized into two groups of 6 rats each: V T8 (V T, 8 mL/kg; 61.50 ± 0.92 breaths/min; positive end-expiratory pressure, 3.0 cmH2O; peak airway pressure (PAW), 11.8 ± 2.0 cmH2O), and V T27 (V T, 27 mL/kg; 33.60 ± 1.56 breaths/min; positive end-expiratory pressure, none, and PAW, 22.7 ± 4.0 cmH2O). Throughout the experiment, mean PAW remained comparable between the two groups (6.33 ± 0.21 vs 6.50 ± 0.22 cmH2O). For rats in the V T27 group,...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Artificial respiration; Kidney; Physiology; Glomerular filtration rate; Wistar rats.
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2009001100017

Actions of Crotalus durissus terrificus venom and crotoxin on the isolated rat kidney
Provedor de dados: 56
Autores: Monteiro,H.S.A.; Silva,I.M.S.C. da; Martins,A.M.C.; Fonteles,M.C.
Many studies have reported the occurrence of lethal acute renal failure after snakebites. The aim of the present investigation was to determine alterations in renal function produced by Crotalus durissus terrificus venom and crotoxin as well as the histological alterations induced by these venoms. Isolated kidneys from Wistar rats weighing 240 to 280 g were perfused with Krebs-Henseleit solution containing 6 g% of previously dialyzed bovine serum albumin. The effects of Crotalus durissus terrificus venom and crotoxin were studied on glomerular filtration rate (GFR), urinary flow (UF), perfusion pressure (PP) and percentage sodium tubular transport (%TNa+). The infusion of Crotalus durissus terrificus venom (10 µg/ml) and crotoxin (10 µg/ml) increased GFR...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Crotalus durissus terrificus venom; Crotoxin; Kidney.
Ano: 2001
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2001001000017

Guanylin peptides: cyclic GMP signaling mechanisms
Provedor de dados: 56
Autores: Forte,L.R.; Freeman,R.H.; Krause,W.J.; London,R.M.
Guanylate cyclases (GC) serve in two different signaling pathways involving cytosolic and membrane enzymes. Membrane GCs are receptors for guanylin and atriopeptin peptides, two families of cGMP-regulating peptides. Three subclasses of guanylin peptides contain one intramolecular disulfide (lymphoguanylin), two disulfides (guanylin and uroguanylin) and three disulfides (E. coli stable toxin, ST). The peptides activate membrane receptor-GCs and regulate intestinal Cl- and HCO3- secretion via cGMP in target enterocytes. Uroguanylin and ST also elicit diuretic and natriuretic responses in the kidney. GC-C is an intestinal receptor-GC for guanylin and uroguanylin, but GC-C may not be involved in renal cGMP pathways. A novel receptor-GC expressed in the opossum...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Kidney; Intestine; Guanylate cyclase; Chloride secretion; Sodium excretion.
Ano: 1999
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999001100002

Renal effects of uroguanylin and guanylin in vivo
Provedor de dados: 56
Autores: Carrithers,S.L.; Hill,M.J.; Johnson,B.R.; O'Hara,S.M.; Jackson,B.A.; Ott,C.E.; Lorenz,J.; Mann,E.A.; Giannella,R.A.; Forte,L.R.; Greenberg,R.N.
Uroguanylin and guanylin are newly discovered endogenous heat-stable peptides that bind to and activate a membrane bound guanylyl cyclase signaling receptor (termed guanylyl cyclase C; GC-C). These peptides are not only found in blood but are secreted into the lumen of the intestine and effect a net secretion of electrolytes (Na+, K+, Cl-, HCO3-) and fluid into the intestine via a cyclic guanosine-3',5'-monophosphate (cGMP) mechanism. GC-C is also the receptor for Escherichia coli heat-stable enterotoxin (STa) and activation by STa results in a diarrheal illness. Employing mouse renal in vivo models, we have demonstrated that uroguanylin, guanylin, and STa elicit natriuretic, kaliuretic, and diuretic effects. These biological responses are time- and...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Guanylyl cyclase C; Heat-stable enterotoxin; Kidney; Natriuresis; Sodium-potassium ATPase; Differential display PCR.
Ano: 1999
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999001100003

Intermittent hemodialysis in dogs with chronic kidney disease stage III
Provedor de dados: 65
Autores: Melchert,Alessandra; Geraldes,Silvano Salgueiro; Vieira,André Nanny Le Sueur; Takahira,Regina Kiomi; Ramos,Paulo Roberto Rodrigues; Barretti,Pasqual; Padovani,Carlos Roberto; Sant’Ana,Paula Bilbau; Ribeiro,José Francisco Antunes; Guimarães-Okamoto,Priscylla Tatiana Chalfun.
ABSTRACT: Intermittent hemodialysis (IHD) is a form of renal replacement that is used in veterinary medicine for cases involving drug removal, electrolyte imbalance, acute kidney injury, and chronic kidney disease (CKD). The aim of the present study was to verify the efficacy of IHD in dogs with CKD staged at grade III and to evaluate the effect of IHD on quality of life. Twelve dogs with CKD at stage III met the inclusion criteria and were divided equally into two groups. The control group (n=6) received only clinical treatment and intravenous fluid therapy, and the hemodialysis group (n=6) received clinical and IHD treatments. Blood samples were collected before and after treatments in both groups. We evaluated complications and clinical parameters of...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Dialysis; CKD; Kidney; Nephrology; Dog.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782017001000601

Renal cell carcinoma with peritoneal carcinomatosis in a mare
Provedor de dados: 65
Autores: Mesquita,Leonardo Pereira; Mesquita Neto,Francisco Duque de; Varaschin,Mary Suzan; Wouters,Angélica Terezinha Barth; Wouters,Flademir.
ABSTRACT: Renal cell carcinoma, especially with extensive involvement of peritoneal cavity, is rarely described in horses. This study described a case of renal cell carcinoma in an 8-year-old mare, which presented with an enlargement in the left flank, decreased appetite and straining to defecate. Clinically, a tumor in the left retroperitoneal space was detected by rectal examination and ultrasonography. The animal died after one month of clinical evolution. At necropsy, the left kidney was completely effaced by a 50cm in diameter, irregular, round, lobulated cystic mass with necro-hemorrhagic areas. Within the peritoneal cavity, there was severe hemoperitoneum and numerous sessile and pedunculated masses ranging from 2.0 to 15.0cm diameter that were...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Equine; Renal neoplasia; Pathology; Kidney; Tumor.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782017000100602

Protein concentrates obtained from pig by-products using pH-shifting technique: a preliminary study
Provedor de dados: 65
Autores: Costa,Claudine Garcia Chaves da; Paula,Marielle Maria de Oliveira; Massingue,Armando Abel; Torres Filho,Robledo de Almeida; Ramos,Eduardo Mendes; Carneiro,João de Deus de Souza.
ABSTRACT:  This study aimed to investigate the extraction and characterization of protein concentrates from pig by-products (heart, liver and kidneys) using the pH-shifting technique. From the solubility profiles (pH 2 to 12), the protein extraction was performed at alkaline pH (10.0 to 11.5), obtaining two fractions: soluble (SC) and insoluble (IC). Higher protein content (71 to 77%) and extractability (214 to 459 mg/g) were observed in heart and liver concentrates; whereas, for water holding capacity (WHC) the highest values (4.20 to 4.54 g water/g protein) were for the heart (SC) and kidney (SC and IC) concentrates. All concentrates had high emulsion stability and higher WHC than commercial protein extenders (whey and soybean). The concentrates obtained...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Heart; Kidney; Liver; Protein extensor; PH-shifting.
Ano: 2019
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782019000600751

Anatomo-pathological and epidemiological analysis of urinary tract lesions in dogs
Provedor de dados: 65
Autores: Sapin,Carolina da Fonseca; Silva-Mariano,Luisa Cerqueira; Bassi,Jordana Nunes; Grecco,Fabiane Borelli.
ABSTRACT: In dogs, diseases of the urinary tract are common and can be caused by disorders of varied etiology. The objective of this study was to classify qualitatively and quantitatively urinary tract lesions of 363 dogs, which were classified according to its anatomical distribution and etiology. The data was obtained from the revision of 36 years of protocols from the Regional Laboratory of Diagnosis (LRD/UFPel) and it represents 4.0% of diagnoses from a total of 8980 for that period and species. Renal injury accounted for 93.1% of cases, with 309 being primary kidney lesions; from which the main lesions were the tubulointerstitial nephritis (142 cases) often associated with Leptospirosis (47). Injuries of lower urinary tract accounted for 6.9% of the...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Dogs; Urinary tract; Kidney; Nefritis.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782016000801443