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1,3,4-Thiadiazole and 1,2,4-triazole-3(4 H )-thione bearing salicylate moiety: synthesis and evaluation as anti- Candida albicans BJPS
Radwan,Awwad Abdoh; Alanazi,Fares Kaed; Al-Agamy,Mohammed Hamed.
Abstract Dramatically increased occurrence of both superficial and invasive fungal infections has been observed. Candida albicans appear to be the main etiological agent of invasive fungal infections. The anti-C. albicans activity of thiosemicarbazide, 1,3,4-Thiadiazole, and 1,2,4-triazole-3(4H)-thione compounds (compounds 3-23) were investigated. The MIC values of thiadiazole and triazole derivatives 10-23 were in the range of 0.08-0.17 µmol mL-1, while that of fluconazole was 0.052 µmol mL-1. Compound 11 (5-(2-(4-chlorobenzyloxy)phenyl)-N-allyl-1,3,4-thiadiazol-2-amine) and compound 18 (5-(2-(4-chlorobenzyloxy)phenyl)-4-allyl-2H-1,2,4-triazole-3(4H)-thione) were found to be the most active compounds, with MIC values of 0.08 µmol mL-1. The newly...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Anti-Candida/docking studies; Thiadiazole; Triazole.
Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502017000100614
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ความไวต่อสารเคมี Propiconazole ของเชื้อรา Bipolaris oryzae สาเหตุโรคใบจุดสีน้ำตาลในพื้นที่นาภาคกลาง Thai Agricultural
Sith Jaisong; Rasamee Dthikiattipong; Witchuda Rattanakarn; Wanporn Kemmuk; Kanungnid Sriwilai.
Fungicides are important tool for managing diseases in many crops. For example, managing Brown spot of rice relies on the application of fungicides. The heavy use of fungicides has triggered to the development of isolates of Bipolaris oryzae (Helminthosporium oryzae) resistant to fungicides. This survey, the farmers randomly were interviewed about fungicide application, showed that most of farmers (76%) used triazole fungicide. 18, 16, 8 and 8 % used dithiocarbamat, triazolobenzo strobirulin and benzimidazole repectively. In vitro fungicide sensitivity assays using poison media technique expressed propiconazole and haxaconazole at concentration 10 ppm inhibit completely mycelium growth. This study was undertaked for evaluating the prevalence of fungicide...
Tipo: PhysicalObject Palavras-chave: Bipolaris oryzae; Helminthosporium oryzae; Fungicide resistance; Brown spot; Propiconazole; Triazole; Rice; เชื้อรา; ความต้านทานสารเคมีกำจัดเชื้อรา; โรคใบจุดสีน้ำตาล; โพรพิโคนาโซล; ประสิทธิภาพการควบคุมโรค.
Ano: 2013 URL: http://anchan.lib.ku.ac.th/agnet/handle/001/5710
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