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| Registros recuperados: 48 | |
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| Nascimento, Luciana Cordeiro do; Universidade Federal da Paraíba; Nery, Aparecida Rodrigues; UFP; Rodrigues, Luís Nery; UFCG. |
| O presente trabalho teve como objetivo avaliar o controle de doenças do mamoeiro, utilizando extratos vegetais (alho, angico e manjericão), óleos naturais (urucum e algodão), indutores de resistência (Bion®, Ecolife® e Agro-mos®) e fungicida Mancozeb/Dithane. O Experimento I consistiu-se da avaliação dos tratamentos sobre o crescimento micelial de Colletotrichum gloeosporioides, in vitro; no Experimento II, efetuou-se a inoculação artificial do fungo sobre frutos sadios de mamão e avaliou-se a severidade da podridão peduncular, por meio de escala de notas e, no Experimento III, aplicaram-se os tratamentos em mudas de mamoeiro, inoculadas artificialmente com C. gloeosporioides, avaliando-se a antracnose com escala de notas. Os resultados obtidos... |
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Palavras-chave: 5.01.00.00-9 Agronomia Carica papaya L.; Antracnose; Produtos naturais; Pós-colheita Fitossanidade Carica papaya L.; Anthracnose; Natural products; Postharvest. |
| Ano: 2008 |
URL: http://periodicos.uem.br/ojs/index.php/ActaSciAgron/article/view/3500 |
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| SOUZA,JULIANA M. DE; GALAVERNA,RENAN; SOUZA,ALINE A.N. DE; BROCKSOM,TIMOTHY J.; PASTRE,JULIO C.; SOUZA,RODRIGO O.M.A. DE; OLIVEIRA,KLEBER T. DE. |
| ABSTRACT We present a comprehensive review of the advent and impact of continuous flow chemistry with regard to the synthesis of natural products and drugs, important pharmaceutical products and definitely responsible for a revolution in modern healthcare. We detail the beginnings of modern drugs and the large scale batch mode of production, both chemical and microbiological. The introduction of modern continuous flow chemistry is then presented, both as a technological tool for enabling organic chemistry, and as a fundamental research endeavor. This part details the syntheses of bioactive natural products and commercial drugs. |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Continuous flow; Natural products; APIs; Synthesis. |
| Ano: 2018 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652018000301131 |
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| Antinarelli,Luciana M.R.; Pinto,Nícolas C.; Scio,Elita; Coimbra,Elaine S.. |
| Leishmaniasis is a complex of diseases caused by Leishmania protozoa which treatment is restricted to a limited number of drugs that exhibit high toxicity, collateral effects and are often costly. There are a variety of tropical plants distributed in Brazil, and for many poor people the therapy for several diseases is based mainly on the use of traditional herbal remedies. In this work, the cytotoxic activity of 17 plant methanol extracts was evaluated on several Leishmania species and murine macrophages. Among them, the extract of Casearia sylvestris, Piptocarpha macropoda, Trembleya parviflora, Samanea tubulosa and Plectranthus neochilus showed a promissing leishmanicidal activity, exhibiting IC50 values below of 20 µg/mL against at least one species of... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Brazil; Casearia sylvestris; Leishmanicidal activity; Medicinal plants; Natural products. |
| Ano: 2015 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652015000200733 |
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| MERCADANTE-SIMÕES,MARIA OLÍVIA; MAZZOTTINI-DOS-SANTOS,HELLEN C.; NERY,LAYS A.; FERREIRA,PERACIO R.B.; RIBEIRO,LEONARDO M.; ROYO,VANESSA A.; OLIVEIRA,DARIO A. DE. |
| The bark of the underground stem of Tontelea micrantha (Mart. ex. Schult.) A. C. Sm., a native Brazilian Cerrado species, is used in folk medicine for treating kidney ailments. The structures of the underground and the aerial stems were examined and their barks were analyzed for the presence of secondary metabolites. Bark fragments were processed according to conventional techniques in plant anatomy and their chemical compositions examined using histochemical and phytochemical tests, thin layer chromatography, and high-efficiency liquid chromatography. The underground stem is a sobol with unusual cambial activity. Laticifers that secrete terpenoids were present in the cortex and phloem of both organs and can contribute to the identification of the species... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Natural products; Pharmacognosy; Secondary metabolites; Sobol. |
| Ano: 2014 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652014000301167 |
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| GÓMEZ-CANSINO,ROCIO; GUZMÁN-GUTIÉRREZ,SILVIA LAURA; CAMPOS-LARA,MARÍA GUADALUPE; ESPITIA-PINZÓN,CLARA INES; REYES-CHILPA,RICARDO. |
| ABSTRACT In Mexican Traditional Medicine 187 plant species are used in the treatment of respiratory conditions that may be associated with tuberculosis. In this contribution, we review the ethnobotany, chemistry and pharmacology of 63 species whose extracts have been assayed for antimycobacterial activity in vitro. Among these, the most potent is Aristolochia brevipes (MIC= 12.5 µg/mL), followed by Aristolochia taliscana, Citrus sinensis, Chrysactinia mexicana, Persea americana, and Olea europaea (MIC<64 µg/mL). Other potent extracts (inhibition > 95%, 50 µg/mL) include: Amphipterygium adstringens, Larrea divaricata, and Phoradendron robinsoni. Several active compounds have been identified, the most potent are: Licarin A (isolated from A. taliscana),... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Tuberculosis; Medicinal plants; Natural products; Mycobacterium tuberculosis. |
| Ano: 2017 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652017000100031 |
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| WISINTAINER,GABRIELLE G.N.S.; SIMÕES,EVELYNE R.B.; LEMOS,TELMA L.G.; MOURA,SIDNEI; SOUZA,LUCIANA G.S.; FONSECA,ALUISIO M.; MORAES,MANOEL ODORICO; PESSOA,CLAUDIA; ROESCH-ELY,MARIANA; HENRIQUES,JOÃO A.P.. |
| Biflorin is an o-naphthoquinone with proven cytotoxic effects on tumor cells showing antimicrobial, antitumor and antimutagenic activities. Biflorin is an isolated compound taken from the roots of the plantCapraria biflora L. (Schrophulariaceae), indigenous of the West Indies and South America, which is located in temperate or tropical areas. This compound has shown to be strongly active against grampositive and alcohol-acid-resistant bacteria. It has been efficient in inhibiting the proliferation tumor cell lines CEM, HL-60, B16, HCT-8 and MCF-7. Recently, SK-Br3 cell line was treated with biflorin showing important cytotoxic effects. In this article, information related to the first structural characterization studies are presented, as well as the latest... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Biological activity; Biflorin; Capraria biflora; Natural products. |
| Ano: 2014 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652014000401907 |
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| Braga,Virgínia F.; Mendes,Giselle C.; Oliveira,Raphael T.R.; Soares,Carla Q.G.; Resende,Cristiano F.; Pinto,Leandro C.; Santana,Reinaldo de; Viccini,Lyderson F.; Raposo,Nádia R.B.; Peixoto,Paulo H.P.. |
| This work describes an efficient micropropagation protocol for Verbena litoralis and the study of the antinociceptive and antioxidant activities in extracts of this species. For the establishment in vitro, surface-sterilization procedures and PVPP showed high efficiency in fungal-bacterial contamination and phenol oxidation controls. Nodal segments cultivation in MS medium supplemented with 6-benzyladenine (7.5 µM)/α-naphthaleneacetic acid (NAA; 0.005 µM) induced multiple shoots. Elongated shoots were rooted with IAA (0.2 µM). Acclimatization rates were elevated and the plants showed the typical features of this species. The hexanic fraction (HF) of powdered leaves presented a radical scavenging activity with IC50 = 169.3 µg mL-1. HF showed a non-dose... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Tissue culture; Biodiversity conservation; Biological effects; Natural products. |
| Ano: 2012 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652012000100014 |
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| Arantes,L.P.; Machado,M.L.; Zamberlan,D.C.; da Silveira,T.L.; da Silva,T.C.; da Cruz,I.B.M.; Ribeiro,E.E.; Aschner,M.; Soares,F.A.A.. |
| Guarana (Paullinia cupana) is habitually ingested by people in the Amazon region and is a key ingredient in various energy drinks consumed worldwide. Extension in longevity and low prevalence of chronic age-related diseases have been associated to habitual intake of guarana. Anti-aging potential of guarana was also demonstrated in Caenorhabditis elegans; however, the mechanisms involved in its effects are not clear. Herein, we investigated the putative pathways that regulate the effects of guarana ethanolic extract (GEE) on lifespan using C. elegans. The major known longevity pathways were analyzed through mutant worms and RT-qPCR assay (DAF-2, DAF-16, SKN-1, SIR-2.1, HSF-1). The possible involvement of purinergic signaling was also investigated. This... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Aging; Antioxidant; Guarana; Lifespan; Natural products; Xanthines. |
| Ano: 2018 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2018000900602 |
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| Soares,Luciana Arantes; Sardi,Janaína de Cássia Orlandi; Gullo,Fernanda Patrícia; Pitangui,Nayla de Souza; Scorzoni,Liliana; Leite,Fernanda Sangalli; Giannini,Maria José Soares Mendes; Almeida,Ana Marisa Fusco. |
| Millions of people and animals suffer from superficial infections caused by a group of highly specialized filamentous fungi, the dermatophytes, which only infect keratinized structures. With the appearance of AIDS, the incidence of dermatophytosis has increased. Current drug therapy used for these infections is often toxic, long-term, and expensive and has limited effectiveness; therefore, the discovery of new anti dermatophytic compounds is a necessity. Natural products have been the most productive source for new drug development. This paper provides a brief review of the current literature regarding the presence of dermatophytes in immunocompromised patients, drug resistance to conventional treatments and new anti dermatophytic treatments. |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Dermatophytes; Filamentous fungi; Natural products; Synthetic product. |
| Ano: 2013 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822013000400003 |
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| Registros recuperados: 48 | |
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