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| Registros recuperados: 66 | |
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| Lv,Dan; Pan,Li-hong; Zhang,Ren; Yang,Jie; Chen,Hao; Wen,Yanzhang; Huang,Mi; Ma,Xinhua; Wang,Qiang; Yang,Xinzhou. |
| Hepatocellular carcinoma is one of the most prevalent malignancies and a leading cause of cancer-related mortality worldwide. However, the therapies to prevent hepatocellular carcinoma are still limited and the emergence of drug resistance leads to the development of new anti-cancer drugs and combinational chemotherapy regimens. Our study was aimed to explore the anticancer effects of the essential oil extract (EEEO) from Euphorbia esula which has been widely used in traditional Chinese folk medicine and possessed potential cytotoxic effects in several human tumor cells. However, the mechanisms of EEEO-induced anti-proliferation and apoptosis have not been completely elucidated. In this study, EEEO was prepared by hydro-distillation and the main chemical... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Euphorbia esula; Hepatocellular carcinoma; Apoptosis; Reactive oxygen species; Mitochondrial pathway. |
| Ano: 2020 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502020000100506 |
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| Martins,Carolina Fernandes Ribas; Salles,Bruno César Corrêa; Brigagão,Maisa Ribeiro Pereira Lima; Rodrigues,Maria Rita; Ferreira,Eric Batista; Duarte,Stella Maris da Silveira; Paula,Fernanda Borges de Araujo. |
| abstract This study was conducted to evaluate the effects of the ethanolic extract of Passiflora edulis leaves on blood glucose, protein glycation, NADPH oxidase activity and macrophage phagocytic capacity after Candida albicans exposure in diabetic rats. The Passiflora edulis Sims leaves were dried to 40°C, powdered, extracted by maceration in 70% ethanol, evaporated under reduced pressure and lyophilised. The biochemical tests performed were total phenolic content (TP) as determined by the Folin-Ciocalteu assay, trapping potential DPPH assay and total iron-reducing potential. Diabetes was induced by alloxan injection. Protein glycation was determined by AGE and fructosamine serum concentrations. Extract-treated diabetic animals demonstrated lower... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Passiflora edulis Sims/pharmacognosy; Passiflora edulis Sims/ethanolic extract/effects; Blood glucose; Protein glycation; Reactive oxygen species; Diabetes/treatment/experimental study; Medicinal plants.. |
| Ano: 2015 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502015000400869 |
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| Hameed,Asiya; Qadri,Tabasum N.; Mahmooduzzafar,; Siddiqi,T.O.; Iqbal,M.. |
| Cadmium and Mercury induced varying responses in Abelmoschus esculentus L. in relation to enzymes (ascorbate peroxidase (APX, 1.11.1.11), catalase (CAT, 1.11.1.6), glutathione reductase (GR, 1.6.4.2) and superoxide dismutase (SOD, 1.15.1.1) which are most related to the levels of Hg and Cd applied and concentrations of thiol groups already present or induced upon treatment. In the present investigation varying concentrations of CdCl2 and HgCl2 (0, 0.05, 0.10, 0.50, 1 and 2mM respectively) applied to plant in the soil shows a significant increase in ascorbate peroxidase, glutathione reductase and superoxide dismutase activities, and the respective metal accumulation. It reveals a mechanism for constant detoxification of H2O2 that have to be associated with... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Antioxidative enzymes; Metals detoxification; Reactive oxygen species. |
| Ano: 2011 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1677-04202011000100007 |
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| Ribeiro,Cleberson; Cambraia,José; Peixoto,Paulo Henrique Pereira; Fonseca Júnior,Élcio Meira da. |
| The antioxidant defense system response was evaluated in two rice cultivars (Oryza sativa L.), Fernandes (CNA-1158) and Maravilha (CNA-6843-1), treated with toxic levels of aluminum. After exposure to aluminum we determined plant growth, H2O2 and O2•- contents, lipid peroxidation, antioxidant enzymes activities and ascorbate and dehydroascorbate contents. Al predominantly accumulated in roots of both cultivars but it reduced root and shoot growth only in the Maravilha cultivar. Treatment with aluminum resulted in a reduction of 84 and 60% in the levels of H2O2 in the roots of the cultivars Maravilha and Fernandes, respectively, and of 26% in the levels of O2•- only in the roots of Fernandes cultivar. Increased lipid peroxidation was observed only in the... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Aluminum; Enzymes; Reactive oxygen species; Oryza sativa; Oxidative stress. |
| Ano: 2012 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1677-04202012000200004 |
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| Oliveira,Karen Maciel de; Binda,Nancy Scardua; Lavor,Mário Sérgio Lima; Silva,Carla Maria Osório; Rosado,Isabel Rodrigues; Taguchi,Tatiana Malagoli; Alves,Endrigo Gabellini Leonel; Melo,Marília Martins; Gomez,Marcus Vinícius; Melo,Eliane Gonçalves de. |
| This study aimed to investigate the neuroprotective effect of ω-conotoxin MVIIA (MVIIA) intralesional application in rats submitted to spinal cord injury. Male Wistar rats, weighing 300g±23.4, were distributed in five groups: negative control (SHAM), placebo (PLA), 5μM MVIIA, 10μM MVIIA and 20μM MVIIA MVIIA. After laminectomy of the 12th thoracic vertebra (SHAM), the PLA, 5μM MVIIA, 10μM MVIIA and 20μM MVIIA groups were subjected to acute compressive spinal cord trauma for five minutes, and then five minutes later, the animals received specific treatment in a standard total volume of 2µL, by intralesional route, using sterile PBS as placebo. Locomotor activity was assayed using Basso Beattie Bresnahan (BBB) scale to show the patterning of SCI. With 48... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: MVIIA; Cone snail; Cell viability; Glutamate; Reactive oxygen species; Lipid peroxidation. |
| Ano: 2016 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782016000100150 |
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| Registros recuperados: 66 | |
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