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| Registros recuperados: 2.284 | |
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| Stuart L. Moodie; Nicolas Le Novere; Emek Demir; Huaiyu Mi; Falk Schreiber. |
| Standard graphical representations have played a crucial role in science and engineering throughout the last century. Without electrical symbolism, it is very likely that our industrial society would not have evolved at the same pace. Similarly, specialized notations such as the Feynmann notation or the process flow diagrams did a lot for the adoption of concepts in their own fields. With the advent of Systems Biology, and more recently of Synthetic Biology, the need for precise and unambiguous descriptions of biochemical interactions has become more pressing. While some ideas have been advanced over the last decade, with a few detailed proposals, no actual community standard has emerged. The Systems Biology Graphical Notation (SBGN) is a graphical... |
| Tipo: Manuscript |
Palavras-chave: Biotechnology; Bioinformatics. |
| Ano: 2011 |
URL: http://precedings.nature.com/documents/3721/version/3 |
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| Gary Griffith; Ross Vennell. |
| The Southern Ocean is considered a zone of high nutrients and low chlorophyll (HNLC). Despite the year round availability of nutrients, phytoplankton biomass remains low. Key modes of control are now thought to be light, grazing, iron and supply of silicic acid^1^. Physiological photoprotective mechanisms used by phytoplankton to regulate photosynthesis versus rapid light fluctuations have not been considered important. In diatoms and haptophytes, which are the major component of phytoplankton biodiversity in the Southern Ocean, the one step de-epoxidation of diadinoxanthin (Dd) into diatoxanthin (Dt) of the Dd-cycle constitutes the main photoprotective mechanism^2,3^. Here we show that Southern Ocean diatoms and haptophytes have higher concentrations of... |
| Tipo: Manuscript |
Palavras-chave: Ecology; Earth & Environment. |
| Ano: 2010 |
URL: http://precedings.nature.com/documents/5377/version/1 |
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| Kai Wang; Shile Zhang; Jessica Weber; David Baxter; David J. Galas. |
| The discovery of microRNAs (miRNAs) as a new class of regulators of gene expression has triggered an explosion of research, but has left many unanswered questions about how this regulation works and how it is integrated with other regulatory mechanisms. A number of miRNAs have been found to be present in blood plasma and other body fluids of humans and mice in surprisingly high concentrations. This observation was unexpected in two respects: first, the fact that these molecules are present at all outside the cell at significant concentrations; and second, that these molecules appear to be stable outside of the cell. In light of this it has been suggested that the biological function of miRNAs may also extend outside of the cell and mediate cell-cell... |
| Tipo: Manuscript |
Palavras-chave: Molecular Cell Biology. |
| Ano: 2009 |
URL: http://precedings.nature.com/documents/3718/version/1 |
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| Sohail Ahmad. |
| Previously, the concept of a gestation period of sheep shorter than 121 days was unheard of in the field of sheep biology. Our findings during a farmers’ survey in the Lotkho area of Chitral, Pakistan, revealed that the sheep native to the region, locally called “Kari”, gestates for a period of only three months. This duration is 25-40% short of the usual gestation length and is shorter than ever recorded for the species. The mean and mode gestation length (GL) was 110 and 92 days respectively and was concentrated in three distinct clusters: day 87-95, 120-123 and 151-153, accounting for 52% of all observations. GL was influenced by location, season of conception and lambing and the interaction of location with season; had... |
| Tipo: Manuscript |
Palavras-chave: Ecology. |
| Ano: 2008 |
URL: http://precedings.nature.com/documents/1620/version/1 |
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| Gudmundur A. Thorisson; Mikael Linden; Anthony J. Brookes; Myles Byrne; Juha Muilu; Tommi Nyronen. |
| Motivation for the IRISC workshop came from the observation that identity and digital identification are increasingly important factors in modern scientific research, especially with the now near-ubiquitous use of the Internet as a global medium for dissemination and debate of scientific knowledge and data, and as a platform for scientific collaborations and large-scale e-science activities.

The 1 1/2 day IRISC2011 workshop sought to explore a series of interrelated topics under two main themes: i) unambiguously identifying authors/creators & attributing their scholarly works, and ii) individual identification and access management in the context of identity federations. Specific aims of the workshop... |
| Tipo: Manuscript |
Palavras-chave: Biotechnology; Data Standards. |
| Ano: 2011 |
URL: http://precedings.nature.com/documents/6609/version/1 |
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| Lucie Kalvodova; Yongmin Zhang. |
| In this short report, we demonstrate that liposomes bearing the Lewis X trisaccharide on the surface (“Awesosomes”) efficiently target human dendritic cells. We chose a glycolipid with Lewis X trisaccharide headgroup to facilitate the targeted liposome uptake via the DC-SIGN internalization pathway. While no uptake of Awesosomes was detected with wild-type human HEK293 cells, HEK293 cells transfected with human DC-SIGN internalized Awesosomes extensively. In samples of human blood-derived leukocytes, the extent of uptake of Awesosomes correlated with the expression of DC-SIGN, which is a dendritic cells marker. There was a marked difference in the uptake of Awesosomes and plain liposomes by DC-SIGN expressing dendritic cells. There... |
| Tipo: Manuscript |
Palavras-chave: Immunology; Pharmacology. |
| Ano: 2010 |
URL: http://precedings.nature.com/documents/4764/version/1 |
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| Wei Sheng Zeng; Shou Zheng Tang; Qian Hui Xiao. |
| Calorific values of plants are important indices for evaluating and reflecting material cycle and energy conversion in forest ecosystems. Based on the data of Masson Pine (Pinus massoniana) in southern China, the calorific values (CVs) and ash contents (ACs) of different plant organs were analyzed systematically using hypothesis test and regression analysis in this paper. The results show: (i) the CVs and ACs of different plant organs are almost significantly different, and the order by AFCV (ash-free calorific value) from the largest to the smallest is foliage (23.55 kJ/g), branches (22.25 kJ/g), stem bark (21.71 kJ/g), root (21.52 kJ/g) and stem wood (21.35 kJ/g); and the order by AC is foliage (2.35%), stem bark (1.44%), root (1.42%), branches (1.08%)... |
| Tipo: Manuscript |
Palavras-chave: Ecology. |
| Ano: 2012 |
URL: http://precedings.nature.com/documents/6750/version/1 |
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| Kojiro Yano. |
| Background:Detection of correlated gene expression is a fundamental process in the characterization of gene functions using microarray data. Commonly used methods such as the Pearson correlation can detect only a fraction of interactions between genes or their products. However, the performance of correlation analysis can be significantly improved either by providing additional biological information or by combining correlation with other techniques that can extract various mathematical or statistical properties of gene expression from microarray data. In this article, I will test the performance of three correlation methods-the Pearson correlation, the rank (Spearman) correlation, and the Mutual Information approach-in detection of protein-protein... |
| Tipo: Manuscript |
Palavras-chave: Biotechnology; Genetics & Genomics; Bioinformatics. |
| Ano: 2010 |
URL: http://precedings.nature.com/documents/4430/version/1 |
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| Robert Muetzelfeldt. |
| Most simulation models in ecological and environmental research are implemented as computer programs in a conventional programming language. This brief paper argues for a radically different approach, based on the representation of the model structure, relationships and equations in a declarative format (e.g. XML). Simulation code can then be generated from this, but in addition the model can be displayed and processed in a wide range of useful ways, greatly increasing the efficiency and effectiveness of the modelling process. |
| Tipo: Manuscript |
Palavras-chave: Ecology; Earth & Environment. |
| Ano: 2007 |
URL: http://precedings.nature.com/documents/17/version/1 |
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| Örjan Hallberg. |
| Incidence rates of several cancers, including melanoma of the skin and breast cancer, have increased since the middle of the 20th century in Western countries. Here, we developed a model for cancer incidence over time, when considering a suddenly increased cancer risk from an environmental change. A two parameter exponential function was used to simulate cancer risk over calendar time since birth, taking into account the time lapse since the environmental change took place. The calculated incidence for all age cohorts over calendar time was used to calculate the age-standardized rates. The best fit between calculated and reported age-standardized rates was sought by parameter variation. The model was tested using reported rates for melanoma and breast... |
| Tipo: Manuscript |
Palavras-chave: Cancer. |
| Ano: 2012 |
URL: http://precedings.nature.com/documents/6779/version/1 |
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| Karo Michaelian. |
| The homochirality of the molecules of life has been a vexing problem with no generally accepted solution to date. Since a racemic mixture of chiral nucleotides frustrates the extension and replication of RNA and DNA, understanding the origin of homochirality has important implications to the investigation of the origin of life. Theories on the origin of life have generally elected to presume an abiotic mechanism giving rise to a large prebiotic enantiomer enrichment. Although a number of such mechanism have been suggested, none has enjoyed sufficient plausibility or relevance to be generally accepted. Here we suggest a novel solution to the homochirality problem based on a recently proposed thermodynamic dissipation theory for the origin of life. The... |
| Tipo: Manuscript |
Palavras-chave: Genetics & Genomics; Evolutionary Biology. |
| Ano: 2010 |
URL: http://precedings.nature.com/documents/5177/version/1 |
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| Khalisanni Khalid; Lee Hung Kiong. |
| Lactic Acid Bacteria was known as potential probiotic used in food industries and dairy products and probable to produce antimicrobial compound that inhibit variety of microorganisms. The objectives of the research are to determine the optimum condition and glucose utilization in relation to antimicrobial compound production. Two species of Lactic Acid Bacteria namely Lactococcus and Lactobacillus were used as probiotic. The Lactic Acid Bacteria were fermentated in different medium, initial substrate pH and incubation temperature for the production of antimicrobial compound. The test organisms such as E.coli and Salmonella were selected as test organisms. Amongst the two species of Lactic Acid Bacteria, Lactococcus produced the highest amount of... |
| Tipo: Manuscript |
Palavras-chave: Biotechnology. |
| Ano: 2009 |
URL: http://precedings.nature.com/documents/3326/version/1 |
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| Michael J. Bucknum. |
| Lattice parameters (a & c) of powdered, polycrystalline calcite in the trigonal-hexagonal system have been determined as a function of pressure and temperature using a hydrothermal diamond anvil cell (DAC), that has been separately described, and a synchrotron x-ray source. Diffraction data was collected using white synchrotron radiation in an energy dispersive technique (EDXRD). Temperature in the resistance heated hydrothermal DAC was measured by thermocouples to a maximum temperature of 800 K, and pressure was measured by the equation of state (EOS) of water, in which powdered calcite was immersed, to a maximum pressure of 7.62 Kb. The resulting study is an attempt to explore the potential of calcite as a double (P & T) internal x-ray... |
| Tipo: Manuscript |
Palavras-chave: Chemistry; Earth & Environment. |
| Ano: 2008 |
URL: http://precedings.nature.com/documents/1514/version/1 |
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| Wei Sheng Zeng; Shou Zheng Tang. |
| Non-linear models with heteroscedasticity are commonly used in ecological and forestry modeling, and logarithmic regression and weighted regression are usually employed to estimate the parameters. Using the single-tree biomass data of three large samples, the bias correction in logarithmic regression for non-linear models was studied and comparison between logarithmic regression and weighted regression was discussed in this paper. Firstly, the imminent cause producing bias in logarithmic regression was analyzed, and a new correction factor was presented with which three commonly used bias correction factors were examined together, and the results showed that the correction factors presented here and derived by Baskerville (1972) should be recommended,... |
| Tipo: Manuscript |
Palavras-chave: Ecology. |
| Ano: 2011 |
URL: http://precedings.nature.com/documents/6708/version/1 |
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| Registros recuperados: 2.284 | |
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