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| Registros recuperados: 2.284 | |
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| Taras K. Oleksyk. |
| The genome of the Puerto Rican parrot (Amazona vittata) has been sequenced and assembled in an international collaboration supported by many individual donations from the people of Puerto Rico. This is a critically endangered endemic bird, the only surviving native parrot species in the territory of the United States, and the first parrot belonging to the large genus Amazona to have its genome sequenced and assembled. A genome of one A. vittata female was sequenced resulting in a total of almost 42.5 billion nucleotide bases equivalent to 26.89X average coverage depth. After filtering out the short fragments (<500bp), the assembly resulted in 259,423 short fragment library contigs, half of them (N50) of at least 6,983 bp in length, with a... |
| Tipo: Manuscript |
Palavras-chave: Genetics & Genomics; Bioinformatics; Evolutionary Biology. |
| Ano: 2011 |
URL: http://precedings.nature.com/documents/6552/version/1 |
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| Takayuki Tanaka; Yuko Ishizaka; Toru Mitushima; Mizuki Tani; Akiko Toda; Eiichi Toda; Minoru Okada; Hiroshi Yamamoto; Minoru Yamakado. |
| Background: The plasma amino acid profile can be a useful indicator in clinical settings because it changes in response to various metabolic alternations. However, the association between the plasma amino acid profile and body fat accumulation has not been evaluated in humans.Objective: This study aimed to relate plasma amino acids to visceral fat accumulation in humans because excess visceral fat raises the odds ratio of developing metabolic syndrome.Design: A total of 1,449 subjects (985 males and 464 females) who had undergone a comprehensive health screening were enrolled in this study. The visceral fat area (VFA) was determined in each subject using CT imaging. Subjects were then divided into two groups according to VFA: high-VFA (≥100 cm2,... |
| Tipo: Manuscript |
Palavras-chave: Bioinformatics. |
| Ano: 2011 |
URL: http://precedings.nature.com/documents/5560/version/1 |
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| Meysam Shafiee Ardestani; Abbas Abbasi. |
| In this research the Abderaz Formation at its type section with an age of Turonian-early Campanian and a thickness of 300 m containing.light grey shale and marls was investigated. Statistical Studise of the morphotype groups of planktonic foraminifera shows that the majority of them are of shallow water forms (SWF) and deep water forms (DWF) and planktonic to benthic ratio is high indicating specific condition of oligotrophy and sedimentation in a relatively deeper marine condition |
| Tipo: Manuscript |
Palavras-chave: Earth & Environment. |
| Ano: 2010 |
URL: http://precedings.nature.com/documents/4359/version/1 |
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| Aaron G. Filler. |
| A steady series of advances in physics, mathematics, computers and clinical imaging science have progressively transformed diagnosis and treatment of neurological and neurosurgical disorders in the 115 years between the discovery of the X-ray and the advent of high resolution diffusion based functional MRI. The story of the progress in human terms, with its battles for priorities, forgotten advances, competing claims, public battles for Nobel Prizes, and patent priority litigations bring alive the human drama of this remarkable collective achievement in computed medical imaging. |
| Tipo: Manuscript |
Palavras-chave: Biotechnology; Cancer; Neuroscience. |
| Ano: 2009 |
URL: http://precedings.nature.com/documents/3267/version/5 |
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| Sierra Rayne; Kaya Forest. |
| Theoretical studies were conducted on the predicted gas and solution phase thermodynamic properties for isomerization of various [1.1]paracyclophane derivatives to their corresponding transannular[4+4] adducts at representative levels of density functional and composite method theory. Calculations suggest the [1.1]paracyclophane to transannular[4+4] adduct isomerizations are not likely amenable to thermodynamic solvent tuning for the methylene, ether, and thioether bridged derivatives using a broad range of nonpolar and polar aprotic and polar protic implicit solvation models, but may be receptive towards solvent tuning for the amine bridged analogs. Varying the nature of the cyclophanic bridging atoms and the electron withdrawing/releasing character of... |
| Tipo: Manuscript |
Palavras-chave: Chemistry. |
| Ano: 2010 |
URL: http://precedings.nature.com/documents/5332/version/1 |
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| Gaurav Pandey; Gowtham Atluri; Michael Steinbach; Vipin Kumar. |
| An application of great interest in microarray data analysis is the identification of a group of genes that show very similar patterns of expression in a data set, and are expected to represent groups of genes that perform common/similar functions, also known as functional modules. Although clustering offers a natural solution to this problem, it suffers from the limitation that it uses all the conditions to compare two genes, whereas only a subset of them may be relevant. Association analysis offers an alternative route for finding such groups of genes that may be co-expressed only over a subset of the experimental conditions used to prepare the data set. The techniques in this field attempt to find groups of data objects that contain coherent values... |
| Tipo: Manuscript |
Palavras-chave: Genetics & Genomics; Molecular Cell Biology; Bioinformatics. |
| Ano: 2008 |
URL: http://precedings.nature.com/documents/2184/version/1 |
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| Sivapuram Venkata Rama Krishna Prabhakar; S Narsa Reddy. |
| A field experiment was conducted to study the effect of different dates of dry seeding and staggered nursery sowing on growth and yield of Kharif rice. The experiment was based on the difficulties faced by the farmers in the coastal areas of Andhra Pradesh and those who depend on canal irrigation and are located at the tail end areas. The experimental results have showed no difference among the methods of stand establishment in terms of yield. However, among the dates of sowing the delay in sowing beyond 30th July significantly reduced the grain yield and returns per rupee invested. It has been concluded that the rice crop may be established either by direct seeding or by transplanting nurseries but the sowing of the respective cultures should be done by... |
| Tipo: Manuscript |
Palavras-chave: Earth & Environment. |
| Ano: 2010 |
URL: http://precedings.nature.com/documents/5399/version/1 |
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| Shantanu Ghosh; Amrita Basu; Subash Khushu; Senthil S. Kumaran. |
| Language, regarded as a hierarchical cognitive code activated by functional operational modes of the brain by most neuropsychologists, is characterized by increased cognitive load in successively higher levels of processing. Language comprehension is posited to be executed through symbolic-iconic information being encoded neurally as modulated phenomena, and can be studied _in vivo_ by functional brain imaging. Using a lexical decision-making task in conjunction with syntactic error correction that effectively isolated the regulatory neural substrate of processing structural-functional information, and minimizing the possible confounds of gender and proficiency, functional magnetic resonance imaging (fMRI) was performed on bilingual volunteers to ascertain... |
| Tipo: Manuscript |
Palavras-chave: Neuroscience. |
| Ano: 2009 |
URL: http://precedings.nature.com/documents/3941/version/1 |
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| Michael A. Corner. |
| Chronic blockade of actively excitatory glutamatergic synaptic receptors in co-cultured organotypic rodent neocortex explants leads to a compensatory up-regulation of otherwise inactive input channels so as to maintain almost normal levels of ongoing bursts of action potentials. We report here that this homeostatic return of spontaneous (now kainate receptor driven) firing is accompanied by a reciprocal down-regulation of blocked AMPA and NMDA receptors, such that the developing cortical network is protected against becoming hyperactive when those synaptic inputs are again able to transmit normally. |
| Tipo: Manuscript |
Palavras-chave: Neuroscience. |
| Ano: 2007 |
URL: http://precedings.nature.com/documents/1260/version/3 |
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| Hua Huang. |
| Evaporation-condensation, a significant process, happens during impact events. Of special interest, this process can lead to significant isotope fractionations e.g. C, O, Mg, Si, S, Fe,and Cr.The nature of mass-independent fractionation of sulphur of the sulfur isotopes is that the fractionation of isotope is still mass dependent during impacts, which means the measured nonzero 
⊿33S values of Archean sulfide- and sulfate-bearing minerals indicate that their different condensation sequences. |
| Tipo: Manuscript |
Palavras-chave: Earth & Environment. |
| Ano: 2010 |
URL: http://precedings.nature.com/documents/4622/version/2 |
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| Rajeev Singh Yadav. |
| Schiff base complexes of oxovanadium(IV) with amino acids and acetylacetone were synthesized and characterized by elemental analysis, conductivity measurements, spectral and magnetic data. The complexes were found to be non-electrolytes and stoichiometry shown 1:1. The spectral and magnetic data were suggesting the square pyramidal geometry |
| Tipo: Manuscript |
Palavras-chave: Chemistry. |
| Ano: 2010 |
URL: http://precedings.nature.com/documents/4378/version/1 |
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| Duhita Narendra; Saruhashi Satoshi; Hamada Kazuo; Miyata Daisuke; Horiike Tokumasa; Shinozawa Takao. |
| The origin of peroxisomes as having developed from the endoplasmic reticulum (ER) was proposed on the basis of the similarity between some peroxisomal proteins and ER proteins, and the localization of some peroxisomal proteins on the ER. To study the evolutionary distance between peroxisomes and ER and Prokaryotes, we carried out a phylogenetic analysis of CDC48 (cell division control 48) and its homologs, including ER-localized CDC48, CDC48 homologs in Prokaryotes and peroxisome-localized PEX1 and PEX6. A similarity search analysis of peroxisomal protein sequences to prokaryotic protein sequences using BLAST at several thresholds (E-values) was also done. We propose Actinobacteria symbiosis for the origin of peroxisomes based on the following evidence:... |
| Tipo: Manuscript |
Palavras-chave: Genetics & Genomics; Evolutionary Biology. |
| Ano: 2008 |
URL: http://precedings.nature.com/documents/1866/version/1 |
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| M.M Ali; Palash Sinha; Sarika Jain; U.C Mohanty. |
| Predicting accurate cyclone tracks is crucial for disaster management practices. The unusual westward movement of the 6-11 May 2002 Arabian Sea cyclone has been investigated through community mesoscale National Centre for Atmospheric Research model by giving different sea surface temperatures (SST) in different experiments keeping all other conditions same. In one experiment, we converted sea surface height anomalies (SSHAs) to SST. Oceanic eddies and SSHAs, representing the subsurface thermal structure, played a prominent role in the unusual westward movement of this cyclone. This is the first time that the effect of eddies and SSHAs on cyclone track has been reported. |
| Tipo: Manuscript |
Palavras-chave: Earth & Environment. |
| Ano: 2007 |
URL: http://precedings.nature.com/documents/1001/version/1 |
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| Barry Smith. |
| Increasingly, in data-intensive areas of the life sciences, experimental results are being described in algorithmically useful ways with the help of ontologies. Such ontologies are authored and maintained by scientists to support the retrieval, integration and analysis of their data. The proposition to be defended here is that ontologies of this type – the Gene Ontology (GO) being the most conspicuous example – are a _part of science_. Initial evidence for the truth of this proposition (which some will find self-evident) is the increasing recognition of the importance of empirically-based methods of evaluation to the ontology develop¬ment work being undertaken in support of scientific research. Ontologies created by... |
| Tipo: Manuscript |
Palavras-chave: Bioinformatics. |
| Ano: 2008 |
URL: http://precedings.nature.com/documents/2027/version/2 |
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| Dong-Young Choi; Randy Hunter; Mei Liu; Wayne Cass; Jignesh Pandya; Patrick Sullivan; Eun-Joo Shin; Hyoung-Chun Kim; Don Gash; Guoying Bing. |
| The specific role of neuroinflammation in the pathogenesis of Parkinson's disease remains to be fully elucidated. By infusing lipopolysaccharide (LPS) into the striatum, we investigated the effect of neuroinflammation on the dopamine nigrostriatal pathway. Here, we report that LPS-induced neuroinflammation in the striatum causes progressive degeneration of the dopamine nigrostriatal system, which is accompanied by motor impairments resembling parkinsonism. Our results indicate that neurodegeneration is associated with defects in the mitochondrial respiratory chain related to extensive S-nitrosylation/nitration of mitochondrial proteins. Mitochondrial injury was prevented by treatment of L-N^6^-(l-iminoethyl)-lysine, an inducible nitric oxide... |
| Tipo: Manuscript |
Palavras-chave: Neuroscience. |
| Ano: 2008 |
URL: http://precedings.nature.com/documents/1970/version/1 |
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| Seikoh Nishida; Tamaki Sasaki; Yasushi Hirokawa; Michihiro Matsuki; Tsutomu Nohno. |
| We first discovered autoantibodies to ACE (angiotensin converting enzyme) in patients with type 2 diabetes mellitus^1^. The antibodies were positive for 64.5% of the patients with diabetes and were positive in 83.3% in the early stage of clinical diabetic nephropathy. In addition, in genetically diabetogenic OLETF (Otsuka Long-Evans Tokushima Fatty) rats^2^, one of the characteristics of which strain is spontaneous nephropathy resembling those of human type 2 diabetes, and in control LETO rats^2^, immunization with rabbit lung ACE developed glomerulopathy similar to that seen in diabetics^3^. Also, in normal New Zealand white rabbits, immunization with the rabbit lung ACE induced glomerular changes similar to those seen in diabetic nephropathy^3^. In this... |
| Tipo: Manuscript |
Palavras-chave: Immunology. |
| Ano: 2009 |
URL: http://precedings.nature.com/documents/3275/version/1 |
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| Jian-Ping Lu; Laura Beatty; Jehonathan Pinthus. |
| Identification of novel protein interactions and their mediators is fundamental in understanding cellular processes and is necessary for protein-targeted therapy. Evidently high throughput formatting of these applications in living cells would be beneficial, however no adequate system exists. We present a novel platform technology for the high throughput screening and verification of protein interactions in living cells. The platform’s series of Dual Expression Recombinase Based (DERB) destiny vectors individually encode two sets of recombinase recognizable sequences for inserting the protein open reading frame (ORF) of interest, two sets of promoters and reporter tags in frame with the ORFs for detecting interactions. Introduction into living... |
| Tipo: Manuscript |
Palavras-chave: Biotechnology; Molecular Cell Biology. |
| Ano: 2008 |
URL: http://precedings.nature.com/documents/1550/version/2 |
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| Stephanie Balor; Marc Daëron; Pierre Bruhns; Denis Hudrisier. |
| T cells acquire various proteins from their cellular partners by the process of trogocytosis. We recently demonstrated that the FcγRIIIA receptor and its associated FcRγ are captured by T cells during their co-culture with FcγR-expressing target cells upon both antigen- or antibody-mediated stimulation. Interestingly, we found that FcR captured by T cells could bind ligands but did not transmit detectable intracellular signals or signaling-depending functions upon ligand binding suggesting their improper integration in the recipient T cell membrane. In this study, we provide morphological data in support of this hypothesis. Indeed, we show that the FcRγ-subunit, which we used as a fusion to GFP, was clearly present... |
| Tipo: Manuscript |
Palavras-chave: Immunology. |
| Ano: 2009 |
URL: http://precedings.nature.com/documents/3824/version/1 |
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| Yeturu Kalidas; Nagasuma Chandra. |
| Background: Recognizing similarities and deriving relationships among protein molecules is a fundamental
requirement in present-day biology. Similarities can be present at various levels which can be detected through comparison of protein sequences or their structural folds. In some cases similarities obscure at these levels could be present merely in the substructures at their binding sites. Inferring functional similarities between protein molecules by comparing their binding sites is still largely exploratory and not as yet a routine protocol. One of
the main reasons for this is the limitation in the choice of appropriate analytical tools that can compare binding sites with high sensitivity. To benefit from the... |
| Tipo: Manuscript |
Palavras-chave: Bioinformatics. |
| Ano: 2008 |
URL: http://precedings.nature.com/documents/2142/version/2 |
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| Registros recuperados: 2.284 | |
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