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| SASAKI, Naoki; LEE, Inhyung; AYUKAWA, Yu; YAMADA, Haruo; 佐々木, 直樹. |
| The effects of mosapride, a 5-hydroxytryptamine 4 (5-HT4) receptor agonist, on the motility of horse small intestine were examined by means of electrointestinography (EIG). Six adult healthy thoroughbreds were used, in which EIG signals from the small intestine were measured by a Degetorappar EGG system. Mosapride, dissolved in 200 ml water, was orally administered at a dose of 2 mg/kg. The total power of EIG signals at a frequency band of 3 cpm was 419.1 ± 122.0 (μV) 2 × cpm (n=6) before, and 2,093.6 ± 850.0 (μV)2 × cpm (n=6) after the drug administration, the latter mean value being significantly greater than the former. This result suggests that mosapride has a prokinetic action on the motility of horse small intestine. |
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Palavras-chave: Equine; Gastrokinetic agent; Mosapride; Oral administration; 5-HT4 receptor agonist. |
| Ano: 2004 |
URL: http://ir.obihiro.ac.jp/dspace/handle/10322/3100 |
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| SASAKI, Naoki; LEE, Inhyung; AYUKAWA, Yu; YAMADA, Haruo; 佐々木, 直樹. |
| It is thought that in order to effectively treat gastrointestinal dysfunction, it should be detected at an early stage. The present study aimed to observe the movement via Electrointestinography (EIG) in the small intestine, cecum, right ventral colon and right dorsal colon, and to examine the procedure for assessing gastrointestinal function. Seven healthy thoroughbred horses were used. They were allowed food twice a day. EIG was measured at ten-minute intervals over a 24 hr period, and running spectral analysis was used. As a result, it was clear that EIG could non-invasively assess gastrointestinal function by setting the cut-off value of the frequency band to 1.8-12.0 cpm for a part of the digestive tract which is in a comparatively fixed position. The... |
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Palavras-chave: Electrointestinography; Equine; Intestine; Power spectral analysis; Running spectral analysis. |
| Ano: 2004 |
URL: http://ir.obihiro.ac.jp/dspace/handle/10322/3101 |
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