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	Provedor de dados BJMBR (2) Autor Bacellar,O. (2) Carvalho,E.M. (2) Almeida,R.P. (1) Lessa,H. (1) Ribeiro-de-Jesus,A. (1) Russo,C. (1) Mais... Palavra-chave /FONT> (1) And HLA class I soluble antigen and HLA class I (1) Cytokines (1) FONT FACE=Symbol> (1) G< (1) HLA class I tegumentary leishmaniasis modulation of T cell response by HLA class I interferon-< (1) Human leishmaniasis (1) Immunological responses (1) Leishmaniasis (1) Pathology (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 1998 (2) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Regulation of T cell response to leishmania antigens by determinants of histocompatibility leukocyte class I and II molecules BJMBR Bacellar,O.; Russo,C.; Carvalho,E.M.. It has been shown that HLA class I molecules play a significant role in the regulation of the proliferation of T cells activated by mitogens and antigens. We evaluated the ability of mAb to a framework determinant of HLA class I molecules to regulate T cell proliferation and interferon gamma (IFN-<FONT FACE="Symbol">g</FONT>) production against leishmania, PPD, C. albicans and tetanus toxoid antigens in patients with tegumentary leishmaniasis and healthy subjects. The anti-major histocompatibility complex (MHC) mAb (W6/32) suppressed lymphocyte proliferation by 90% in cultures stimulated with <FONT FACE="Symbol">a</FONT>CD3, but the suppression was variable in cultures stimulated with leishmania antigen. This suppression ranged from... Tipo: Info:eu-repo/semantics/article Palavras-chave: HLA class I tegumentary leishmaniasis modulation of T cell response by HLA class I interferon-<; FONT FACE=Symbol>; G<; /FONT>; And HLA class I soluble antigen and HLA class I. Ano: 1998 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1998001200010 Cytokine profile and pathology in human leishmaniasis BJMBR Ribeiro-de-Jesus,A.; Almeida,R.P.; Lessa,H.; Bacellar,O.; Carvalho,E.M.. The clinical spectrum of leishmaniasis and control of the infection are influenced by the parasite-host relationship. The role of cellular immune responses of the Th1 type in the protection against disease in experimental and human leishmaniasis is well established. In humans, production of IFN-<FONT FACE="Symbol">g</font> is associated with the control of infection in children infected by Leishmania chagasi. In visceral leishmaniasis, an impairment in IFN-<FONT FACE="Symbol">g</font> production and high IL-4 and IL-10 levels (Th2 cytokines) are observed in antigen-stimulated peripheral blood mononuclear cells (PBMC). Moreover, IL-12 restores IFN-<FONT FACE="Symbol">g</font> production and enhances the cytotoxic... Tipo: Info:eu-repo/semantics/article Palavras-chave: Leishmaniasis; Human leishmaniasis; Cytokines; Pathology; Immunological responses. Ano: 1998 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1998000100020 Registros recuperados: 2 Primeira ... 1 ... Última

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