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	Provedor de dados BJM (1) Autor Alfieri,Alice Fernandes (1) Alfieri,Amauri Alcindo (1) Barreiros,Marco Antônio Bacellar (1) Takiuchi,Elisabete (1) Palavra-chave BCoV (1) Cleavage site (1) Mutation (1) Sequencing (1) Spike protein (1) Tipo do documento Info:eu-repo/semantics/article (1) Ano 2007 (1) País Brazil (1) Idioma Inglês (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última Identification of a mutation in the spike protein cleavage site in Brazilian strains of wild-type bovine coronavirus BJM Takiuchi,Elisabete; Barreiros,Marco Antônio Bacellar; Alfieri,Alice Fernandes; Alfieri,Amauri Alcindo. The spike (S) protein of coronaviruses, a type I membrane glycoprotein, is primarily responsible for entry into susceptible cells by binding with specific receptors on cells and mediating subsequent virus-cell fusion. The bovine coronavirus (BCoV) S protein is cleaved into two subunits, the N-terminal S1 and the C-terminal S2. The proteolytic cleavage site of S protein is highly conserved among BCoV strains and is located between amino acids 763 and 768 (KRRSRR). This study describes a single mutation in the S protein cleavage site of three Brazilian strains of BCoV detected in diarrheic fecal samples from calves naturally infected. The sequenced PCR products revealed that amino acid sequence of the cleavage site of our strains was KRRSSR, indicating a... Tipo: Info:eu-repo/semantics/article Palavras-chave: BCoV; Sequencing; Spike protein; Cleavage site; Mutation. Ano: 2007 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822007000400021 Registros recuperados: 1 Primeira ... 1 ... Última

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