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| CIRINO,LORENA M.D.; VERGNE,DAVIANE M.C.; SANTANA,PATRÍCIA F.; ALMEIDA,ENRIK DE; COSTA,LUIZ P. DA; ALBUQUERQUE-JÚNIOR,RICARDO L.C. DE; LIMA-VERDE,ISABEL B.; PADILHA,FRANCINE F.; CARDOSO,JULIANA C.. |
| ABSTRACT The objective of this work was to study the reduction in the capsaicin toxicity by encapsulation in liposomes. Capsaicin was extracted from peppers and characterized with high performance liquid chromatography (HPLC). We determined the zeta potential, polydispersivity index (PdI) and vesicle size of liposomes. Wistar rats were submitted to intravesical instillation of liposomes (LIP), capsaicin (CAP) or liposomes with capsaicin (CAPLIP). After 24 hours, bladders were removed for histological analysis. Vesicle size ranged from 68 to 105 nm with PdI smaller than 0.2 and zeta potential around -30 mV. The vesicles maintained stability over the 14-day study. The histological analysis of the CAP group showed intense inflammation in almost all bladder... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Capsaicin; Liposomes; Urinary incontinence; Intravesical administration. |
| Ano: 2016 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652016000401539 |
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| MARTINS,WALESKA B.; RODRIGUES,SHEYLA A.; SILVA,HATAMY K.; DANTAS,CAMILA G.; JÚNIOR,WALDECY DE LUCCA; FILHO,LAURO XAVIER; CARDOSO,JULIANA C.; GOMES,MARGARETE Z.. |
| ABSTRACT The Portulaca oleracea L. (Portulacaceae) is a cosmopolitan species with a wide range of biological activities, including antioxidant and neuroprotective actions. We investigated the effects of P. oleracea extracts in a 6-hydroxydopamine rat model of Parkinson's disease, a debilitating disorder without effective treatments. Chemical profiles of aqueous and ethanolic extracts of whole plant were analyzed by thin layer chromatography and the antioxidant activity was assessed by 2,2-diphenyl-1-picrilhidrazila method. Male Wistar rats received intrastriatal 6-hydroxydopamine and were treated with vehicle or extracts (oral, 200 and 400 mg/kg) daily for two weeks. The behavioral open field test was conducted at days 1 and 15. Immunohistochemical... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Parkinson Disease; Antioxidant Response Elements; Levodopa; Purslane. |
| Ano: 2016 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652016000401439 |
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