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	Provedor de dados Genet. Mol. Biol. (3) Braz. J. Genet. (1) Autor Dias,Francisca da Luz (4) Takahashi,Catarina S. (3) Antunes,Lusânia M.G. (2) Araújo,Maria Cristina P. (2) Antunes,Lusânia Maria Greggi (1) Araújo,Maria Cristina Paiva (1) Cecchi,Andréa O. (1) Kronka,Sergio N. (1) Takahashi,Catarina Satie (1) Mais... Palavra-chave CHO (1) Chromosomal aberrations (1) Curcumin (1) Hydrogen peroxide (1) Mutagenesis (1) Tipo do documento Info:eu-repo/semantics/article (4) Ano 2005 (1) 1999 (1) 1998 (1) 1997 (1) País Brazil (4) Idioma Inglês (4)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 4 Primeira ... 1 ... Última Effects of H2O2, Fe2+ and Fe3+ on curcumin-induced chromosomal aberrations in CHO cells Genet. Mol. Biol. Antunes,Lusânia Maria Greggi; Araújo,Maria Cristina Paiva; Dias,Francisca da Luz; Takahashi,Catarina Satie. The effects of H2O2, Fe2+ and Fe3+ on curcumin-induced clastogenicity were evaluated in CHO cells. Curcumin combined with H2O2 did not increase the chromosomal aberrations more than expected based on a simple additive effect. In contrast, the combination of curcumin-Fe significantly decreased the total number of chromosomal aberrations and the number of abnormal metaphases. The clastogenicity of curcumin may be related to its pro-oxidant properties and its ability to generate free radicals. Tipo: Info:eu-repo/semantics/article Palavras-chave: CHO; Chromosomal aberrations; Curcumin; Hydrogen peroxide; Mutagenesis. Ano: 2005 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572005000100028 Chromosome damage induced by DNA topoisomerase II inhibitors combined with g-radiation in vitro Genet. Mol. Biol. Araújo,Maria Cristina P.; Dias,Francisca da Luz; Cecchi,Andréa O.; Antunes,Lusânia M.G.; Takahashi,Catarina S.. Combined radiation and antineoplastic drug treatment have important applications in cancer therapy. In the present work, an evaluation was made of two known topoisomerase II inhibitors, doxorubicin (DXR) and mitoxantrone (MXN), with g-radiation. The effects of DXR or MXN on g-radiation-induced chromosome aberrations in Chinese hamster ovary (CHO) cells were analyzed. Two concentrations of each drug, 0.5 and 1.0 µg/ml DXR, and 0.02 and 0.04 µg/ml MXN, were applied in combination with two doses of g-radiation (20 and 40 cGy). A significant potentiating effect on chromosomal aberrations was observed in CHO cells exposed to 1.0 µg/ml DXR plus 40 cGy. In the other tests, the combination of g-radiation with DXR or MXN gave approximately additive effects. Reduced... Tipo: Info:eu-repo/semantics/article Ano: 1998 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47571998000300021 Effects of turmeric and its active principle, curcumin, on bleomycin-induced chromosome aberrations in Chinese hamster ovary cells Genet. Mol. Biol. Araújo,Maria Cristina P.; Dias,Francisca da Luz; Kronka,Sergio N.; Takahashi,Catarina S.. Naturally occurring antioxidants have been extensively studied for their capacity to protect organisms and cells from oxidative damage. Many plant constituents including turmeric and curcumin appear to be potent antimutagens and antioxidants. The effects of turmeric and curcumin on chromosomal aberration frequencies induced by the radiomimetic agent bleomycin (BLM) were investigated in Chinese hamster ovary (CHO) cells. Three concentrations of each drug, turmeric (100, 250 and 500 <FONT FACE="Symbol">m</FONT>g/ml) and curcumin (2.5, 5 and 10 <FONT FACE="Symbol">m</FONT>g/ml), were combined with BLM (10 <FONT FACE="Symbol">m</FONT>g/ml) in CHO cells treated during the G1/S, S or G2/S phases of the cell cycle. Neither... Tipo: Info:eu-repo/semantics/article Ano: 1999 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47571999000300021 Effect of taxol on chromosome aberrations induced by gamma radiation or by doxorubicin in Chinese hamster ovary cells Braz. J. Genet. Dias,Francisca da Luz; Antunes,Lusânia M.G.; Takahashi,Catarina S.. Combined therapy with radiation and chemotherapy has being increasingly used in cancer treatment. The effect of combinations of taxol (0.08 mug/ml) with doxorubicin (DXR, 0.5 or 1.0 mug/ml) or gamma radiation (20 or 40 cGy) was examined in two different treatment schedules (pretreatment or simultaneous treatment) using Chinese hamster ovary (CHO) cells treated at the G2 phase of the cell cycle. The results showed that taxol did not have a radiosensitizing effect on the chromosomal aberrations induced by gamma radiation nor did it have a potentiating effect on the chromosomal aberrations induced by DXR in CHO cells treated in the G2 phase of the cell cycle Tipo: Info:eu-repo/semantics/article Ano: 1997 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-84551997000300006 Registros recuperados: 4 Primeira ... 1 ... Última

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