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| Albino,C.C.; Graf,H.; Paz-Filho,G.; Diehl,L.A.; Olandoski,M.; Sabbag,A.; Buchpiguel,C.. |
| Recombinant human thyrotropin (rhTSH) reduces the activity of radioiodine required to treat multinodular goiter (MNG), but acute airway compression can be a life-threatening complication. In this prospective, randomized, double-blind, placebo-controlled study, we assessed the efficacy and safety (including airway compression) of different doses of rhTSH associated with a fixed activity of 131I for treating MNG. Euthyroid patients with MNG (69.3 ± 62.0 mL, 20 females, 2 males, 64 ± 7 years) received 0.1 mg (group I, N = 8) or 0.01 mg (group II, N = 6) rhTSH or placebo (group III, N = 8), 24 h before 1.11 GBq 131I. Radioactive iodine uptake was determined at baseline and 24 h after rhTSH and thyroid volume (TV, baseline and 6 and 12 months after treatment)... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Hyperthyroidism; Multinodular goiter; Tracheal airway; 131I; Thyrotropin alpha. |
| Ano: 2010 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2010000300013 |
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| Silveira,P.P.; Benetti,C. da Silva; Portella,A.K.; Diehl,L.A.; Molle,R. Dalle; Lucion,A.B.; Dalmaz,C.. |
| Neonatal handling induces several behavioral and neurochemical alterations in pups, including decreased responses to stress and reduced fear in new environments. However, there are few reports in the literature concerning the behavioral effects of this neonatal intervention on the dams during the postpartum period. Therefore, the aim of the current study was to determine if brief postpartum separation from pups has a persistent impact on the dam's stress response and behavior. Litters were divided into two neonatal groups: 1) non-handled and 2) handled [10 min/day, from postnatal day (PND) 1 to 10]. Weaning occurred at PND 21 when behavioral tasks started to be applied to the dams, including sweet food ingestion (PND 21), forced swimming test (PND 28), and... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Feeding behavior; Neonatal handling; Psychostimulants; Stress response; Dam behavior. |
| Ano: 2013 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2013000500426 |
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