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| MARTINS,WALESKA B.; RODRIGUES,SHEYLA A.; SILVA,HATAMY K.; DANTAS,CAMILA G.; JÚNIOR,WALDECY DE LUCCA; FILHO,LAURO XAVIER; CARDOSO,JULIANA C.; GOMES,MARGARETE Z.. |
| ABSTRACT The Portulaca oleracea L. (Portulacaceae) is a cosmopolitan species with a wide range of biological activities, including antioxidant and neuroprotective actions. We investigated the effects of P. oleracea extracts in a 6-hydroxydopamine rat model of Parkinson's disease, a debilitating disorder without effective treatments. Chemical profiles of aqueous and ethanolic extracts of whole plant were analyzed by thin layer chromatography and the antioxidant activity was assessed by 2,2-diphenyl-1-picrilhidrazila method. Male Wistar rats received intrastriatal 6-hydroxydopamine and were treated with vehicle or extracts (oral, 200 and 400 mg/kg) daily for two weeks. The behavioral open field test was conducted at days 1 and 15. Immunohistochemical... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Parkinson Disease; Antioxidant Response Elements; Levodopa; Purslane. |
| Ano: 2016 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652016000401439 |
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