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	Provedor de dados Genet. Mol. Biol. (1) Autor Ferreira,Cristiane A. (1) Garcia,Daniel Fantozzi (1) Garcia,Luiz V. (1) Marques,Adriana A. (1) Molfetta,Greice A. (1) Oliveira,Ticiano G. (1) Silva Jr.,Wilson Araujo (1) Mais... Palavra-chave Butyrylcholinesterase (1) DNA polymorphism (1) Hereditary hypocholinesterasemia (1) Succinylcholine BCHE gene (1) Tipo do documento Info:eu-repo/semantics/article (1) Ano 2011 (1) País Brazil (1) Idioma Inglês (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última Biochemical and genetic analysis of butyrylcholinesterase (BChE) in a family, due to prolonged neuromuscular blockade after the use of succinylcholine Genet. Mol. Biol. Garcia,Daniel Fantozzi; Oliveira,Ticiano G.; Molfetta,Greice A.; Garcia,Luiz V.; Ferreira,Cristiane A.; Marques,Adriana A.; Silva Jr.,Wilson Araujo. Butyrylcholinesterase (BChE) is a plasma enzyme that catalyzes the hydrolysis of choline esters, including the muscle-relaxant succinylcholine and mivacurium. Patients who present sustained neuromuscular blockade after using succinylcholine usually carry BChE variants with reduced enzyme activity or an acquired BChE deficiency. We report here the molecular basis of the BCHE gene underlying the slow catabolism of succinylcholine in a patient who underwent endoscopic nasal surgery. We measured the enzyme activity of BChE and extracted genomic DNA in order to study the promoter region and all exons of the BCHE gene of the patient, her parents and siblings. PCR products were sequenced and compared with reference sequences from GenBank. We detected that the... Tipo: Info:eu-repo/semantics/article Palavras-chave: Hereditary hypocholinesterasemia; Butyrylcholinesterase; Succinylcholine BCHE gene; DNA polymorphism. Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572011000100008 Registros recuperados: 1 Primeira ... 1 ... Última

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