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| Griffin, K.; Matthai, E.; Hommel, M.; Weitz, J. C.; Baxby, D.; Hart, C. A.. |
| A panel of monoclonal antibodies has been produced against the protozoan parasite Cryptosporidium parvum which is a major cause of diarrhoeal disease in man and other animals. C. parvum oocysts from both a human and a bovine case of cryptosporidiosis were used as immunogens. A total of 11 different monoclonal antibodies were obtained which could bind to formalin-fixed oocysts. One was IgA but the remainder were all of IgM isotype. The reactivity of these monoclonal antibodies against a series of C. parvum oocysts obtained from 25 patients in Chile was examined using indirect immuno-fluorescence. Although a mixture of all of the 11 antibodies would have detected oocysts in each of the samples, no one monoclonal antibody recognised all oocysts. Each antibody... |
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Palavras-chave: Cryptosporidium parvum; Monoclonal antibody; Antigenic diversity. |
| Ano: 1992 |
URL: http://ir.obihiro.ac.jp/dspace/handle/10322/169 |
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