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	Provedor de dados Biol. Res. (2) Autor CABELLO,GERTRUDIS (2) INOSTROZA,JUAN (2) PARRA,EDUARDO (2) CALAF,GLORIA (1) SÁENZ,LEONARDO (1) VISSE,EDWARD (1) Mais... Palavra-chave C-Jun N-terminal kinase (1) CD28 response element (1) Extracellular signal regulated kinase (1) Interleukin-2 (1) Kinase JNK-1 (1) Phosphatase PP4 (1) Prostate cancer (1) Staphylococcal Enterotoxin A-E (1) Mais... Tipo do documento Journal article (2) Ano 2005 (1) 2003 (1) País Chile (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última The MAP Kinases are Differently Utilized by CD28 and CD2 Adhesion Pathways in Superantigen-Activated Jurkat T cells Biol. Res. VISSE,EDWARD; INOSTROZA,JUAN; CABELLO,GERTRUDIS; PARRA,EDUARDO. To mimic the two-signal requirements for T cell activation mediated by ligands, we exposed the superantigens SEA or SEE (signal 1) to T cells incubated with HLA-DR/LFA-3 or HLA-DR/B7-1-CHO transfected cells (signal 2). LFA-3 costimulation was able to induce T cell proliferation as well as IFN-g and IL-4 production at similar levels as in cells induced by B7-1. Analysis of the CD28RE of the IL-2 promoter showed specific transcription factor recruitment at the CD28RE element upon induction by B7-1/SEE. Further functional studies with an IL-2 enhancer-promoter carrying either wild type or mutated versions of the CD28RE site revealed that this element is necessary for full activation upon B7-1 costimulation. While both CD28/B7-1 and CD2/LFA-3 costimulation... Tipo: Journal article Palavras-chave: CD28 response element; Staphylococcal Enterotoxin A-E; Extracellular signal regulated kinase; C-Jun N-terminal kinase; Interleukin-2. Ano: 2003 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602003000200016 Role of the phosphatase PP4 in the activation of JNK-1 in prostate carcinoma cell lines PC-3 and LNCaP resulting in increased AP-1 and EGR-1 activity Biol. Res. INOSTROZA,JUAN; SÁENZ,LEONARDO; CALAF,GLORIA; CABELLO,GERTRUDIS; PARRA,EDUARDO. The specific signaling connections between the mitogen-activated protein kinases (MAPK) such as c-Jun N-terminal kinase (JNK-1) and phosphatases PP4 and M3/6, affecting the family of early nuclear factors, is complex and remains poorly understood. JNK-1 regulates cellular differentiation, apoptosis and stress responsiveness by up-regulating early nuclear factors such as c-Jun, a member of the activating protein (AP-1) family, and the Early Growth Factor (EGR-1). C-Jun, when phosphorylated by c-Jun N-terminal kinase (JNK-1) associates with c-Fos to form the AP-1 transcription factor that activates gene expression. We have investigated the regulation of the JNK-1 kinase by co-transfecting phosphatases PP4 and M3/6 in prostate cancer cell lines PC-3 and... Tipo: Journal article Palavras-chave: Prostate cancer; Phosphatase PP4; Kinase JNK-1. Ano: 2005 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602005000200006 Registros recuperados: 2 Primeira ... 1 ... Última

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