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	Provedor de dados BJMBR (2) Autor Gerová,M. (2) Kristek,F. (2) Cacányiová,S. (1) Cebová,M. (1) Palavra-chave Hypertension (2) Artery (1) Conduit iliac artery (1) Extracellular matrix (1) Iliac artery (1) Molsidomine (1) Morphometry (1) Nitric oxide (1) Offspring (1) Pentaerythritol tetranitrate (1) Resistance arteries (1) Structure (1) Vascular smooth muscle (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2005 (1) 2004 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Hypotrophy of conduit artery walls of the offspring of nitric oxide-defective rats BJMBR Kristek,F.; Gerová,M.. The objective of the present study was to investigate the structure of the arterial walls of the offspring stemming from nitric oxide (NO)-defective hypertensive parents. The parents were treated with N G-nitro-L-arginine methyl ester (40 mg kg-1 day-1) for 5 weeks. Blood pressure was measured noninvasively in six 30-day-old rats and nine age-matched controls. The cardiovascular system was perfused with glutaraldehyde at 120 mmHg. The thoracic aorta and carotid artery were processed for electron microscopy, and geometry was determined by light microscopy. Endothelial cells, smooth muscle cells (SMC) and extracellular matrix (ECM) were determined by the point counting method in electron micrographs of the carotid artery. The blood pressure of experimental... Tipo: Info:eu-repo/semantics/article Palavras-chave: Artery; Nitric oxide; Offspring; Hypertension; Vascular smooth muscle; Extracellular matrix; Morphometry. Ano: 2004 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2004000400018 Acetylcholine and bradykinin enhance hypotension and affect the function of remodeled conduit arteries in SHR and SHR treated with nitric oxide donors BJMBR Gerová,M.; Kristek,F.; Cacányiová,S.; Cebová,M.. Discrepancy was found between enhanced hypotension and attenuated relaxation of conduit arteries in response to acetylcholine (ACh) and bradykinin (BK) in nitric oxide (NO)-deficient hypertension. The question is whether a similar phenomenon occurs in spontaneously hypertensive rats (SHR) with a different pathogenesis. Wistar rats, SHR, and SHR treated with NO donors [molsidomine (50 mg/kg) or pentaerythritol tetranitrate (100 mg/kg), twice a day, by gavage] were studied. After 6 weeks of treatment systolic blood pressure (BP) was increased significantly in experimental groups. Under anesthesia, the carotid artery was cannulated for BP recording and the jugular vein for drug administration. The iliac artery was used for in vitro studies and determination... Tipo: Info:eu-repo/semantics/article Palavras-chave: Hypertension; Conduit iliac artery; Resistance arteries; Molsidomine; Pentaerythritol tetranitrate; Iliac artery; Structure. Ano: 2005 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2005000600019 Registros recuperados: 2 Primeira ... 1 ... Última

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