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	Provedor de dados Genet. Mol. Biol. (2) Autor Lage,Claudia (2) Almeida,Renata (1) Alves,Adriana M. (1) Alves,Gilda (1) Cypriano,Ana Sheila (1) Kuster,Ricardo M. (1) Leitão,Alvaro C. (1) Ornellas,Antonio Augusto (1) Scheinkman,José (1) Scherrer,Luciano (1) Vidal,Leonardo S. (1) Mais... Palavra-chave DNA repair (1) Echinodorus macrophyllus (1) Gene-environment interaction (1) Genotoxicity (1) Mutagenesis (1) Prostate cancer (1) Reactive oxygen species (1) Single nucleotide polymorphism (1) XPD (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2017 (1) 2010 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Relationship between XPD, RAD51, and APEX1 DNA repair genotypes and prostate cancer risk in the male population of Rio de Janeiro, Brazil Genet. Mol. Biol. Cypriano,Ana Sheila; Alves,Gilda; Ornellas,Antonio Augusto; Scheinkman,José; Almeida,Renata; Scherrer,Luciano; Lage,Claudia. Abstract Susceptibility to cancer ensues in individuals carrying malfunctioning DNA repair mechanisms. The impact of Single Nucleotide Polymorphisms (SNPs) in key DNA repair mechanisms on risk for prostate cancer was investigated in this case-control study. Samples consisted of 110 patients with confirmed prostate cancer and 200 unaffected men, from Rio de Janeiro, Brazil. XPD/Lys751Gln (rs13181), APEX1/Asp148Glu (rs1130409), and RAD51/G135C (rs1801320) SNPs were analyzed by PCR-RFLP. Allelic and genotypic frequencies were calculated and compared by Chi-Square test. The association between SNPs and clinical/epidemiological data was considered significant by Odds Ratio analysis, with IC95% and a p-value≤0.05. Only the XPD/Lys751Gln SNP significantly... Tipo: Info:eu-repo/semantics/article Palavras-chave: Prostate cancer; Single nucleotide polymorphism; XPD; DNA repair; Gene-environment interaction. Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572017000500751 Genotoxicity and mutagenicity of Echinodorus macrophyllus (chapéu-de-couro) extracts Genet. Mol. Biol. Vidal,Leonardo S.; Alves,Adriana M.; Kuster,Ricardo M.; Lage,Claudia; Leitão,Alvaro C.. Echinodorus macrophyllus, commonly known as chapéu-de-couro, is a medicinal plant used in folk medicine to treat inflammation and rheumatic diseases. In this work, we used short-term bacterial assays based on the induction of SOS functions to examine the genotoxicity and mutagenicity of an aqueous extract of E. macrophyllus leaves. Whole extract and an ethyl acetate fraction showed similar genotoxicity and caused an ~70-fold increase in lysogenic induction. The extract also gave a positive result in the SOS chromotest with an increase of 12-fold in β-Galactosidase enzymatic units. There was a strong trend towards base substitutions and frameshifts at purine sites in the mutations induced by the extract in Escherichia coli (CC103 and CC104 strains) and... Tipo: Info:eu-repo/semantics/article Palavras-chave: Echinodorus macrophyllus; Genotoxicity; Mutagenesis; Reactive oxygen species. Ano: 2010 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572010000300028 Registros recuperados: 2 Primeira ... 1 ... Última

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