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| Zhang,Wei; Lv,Shengqing; Liu,Jun; Zang,Zhenle; Yin,Junyi; An,Ning; Yang,Hui; Song,Yechun. |
| PCI-24781 is a novel histone deacetylase inhibitor that inhibits tumor proliferation and promotes cell apoptosis. However, it is unclear whether PCI-24781 inhibits Enhancer of Zeste 2 (EZH2) expression in malignant gliomas. In this work, three glioma cell lines were incubated with various concentrations of PCI-24781 (0, 0.25, 0.5, 1, 2.5 and 5 M) and analyzed for cell proliferation by the MTS 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium assay and colony formation, and cell cycle and apoptosis were assessed by flow cytometry. The expression of EZH2 and apoptosis-related proteins was assessed by western blotting. Malignant glioma cells were also transfected with EZH2 siRNA to examine how PCI-24781 suppresses tumor... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: EZH2; Malignant gliomas; PCI-24781; PIK3K/Akt/mTOR signaling pathway. |
| Ano: 2014 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572014000500015 |
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| Wang,Congyan; Jiang,Kun; Zhou,Jiawei; Liu,Jun. |
| ABSTRACT Allelopathic suppression of the growth of co-occurring plant species in invaded ecosystems is an important factor in some plant invasions. This study uses leaf extracts of the invasive plant species Conyza canadensis to determine its allelopathic effects along a latitudinal gradient, and under different cover classes and degrees of invasion, on seed germination and growth of Lactuca sativa, a sensitive bioindicator of allelochemicals. The allelopathic effects of C. canadensis on seedling height, root length, seedling biomass, germination percentage, germination potential, germination index, germination rate index, and vigor index of L. sativa increased significantly with increasing latitude. A possible explanation is that the leaves of plants... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Allelopathic effects; Conyza canadensis; Invasive plant species; Lactuca sativa; Seed germination and growth. |
| Ano: 2017 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-33062017000200212 |
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