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| FUNARI,Cristiano S.; ALMEIDA,Letícia de; PASSALACQUA,Thais G.; MARTINEZ,Isabel; AMBRÓSIO,Daniela L.; CICARELLI,Regina Maria B.; SILVA,Dulce Helena S.; GRAMINHA,Márcia A. S.. |
| ABSTRACT Leishmaniasis and Chagas disease affect millions of people in tropical and subtropical regions. Drugs used currently to treat such diseases often present undesirable side effects and low efficiency. The aim of this work was to identify extracts and isolated compounds from the genus Lippia with leishmanicidal and trypanocidal activity. Fifteen extracts from different plant parts of Lippia species with partially known chemical compositions, four partition fractions, six compounds and a mixture of four interconverting flavanones previously isolated from Lippia salviaefolia and Lippia lupulina were assayed in vitro towards epimastigote forms of Trypanosoma cruzi and promastigote forms of Leishmania amazonensis. The root extract of L. lupulina had... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Leishmanicidal; Trypanocidal; Triterpenoids; Flavonoids; T. cruzi. |
| Ano: 2016 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0044-59672016000400411 |
