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Determination of myocardial infarction size in rats by echocardiography and tetrazolium staining: correlation, agreements, and simplifications BJMBR
Dos Santos,L.; Mello,A.F.S.; Antonio,E.L.; Tucci,P.J.F..
Triphenyltetrazolium chloride (TTC) staining and echocardiography (ECHO) are methods used to determine experimental myocardial infarction (MI) size, whose practical applicability should be expanded. Our objectives were to analyze the accuracy of ECHO in determining infarction size in rats during the first days following coronary occlusion and to test whether a simplified single measurement by TTC correctly indicates MI size, as determined by the average value for multiple slices. Infarction was induced in female Wistar rats by coronary artery occlusion and MI size analysis was performed after the acute (7th day) and chronic periods (after 4 weeks) by ECHO matched with TTC. ECHO and TTC showed similar values of MI size (% of left ventricle perimeter) in...
Tipo: Info:eu-repo/semantics/other Palavras-chave: Myocardial infarction size; Echocardiography and triphenyltetrazolium comparison; Bland-Altman test.
Ano: 2008 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2008000300004
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