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| Costal-Oliveira,Fernanda; Guerra-Duarte,Clara; Oliveira,Maira Souza; Castro,Karen Larissa Pereira de; Lopes-de-Sousa,Leticia; Lara,Aline; Gomes,Enéas Ricardo de Morais; Bonilla,Cesar; Guatimosim,Sílvia; Melo,Marília Martins; Chávez-Olórtegui,Carlos. |
| Abstract Background Hadruroides lunatus is the most abundant scorpion species in the Peruvian central coast, where most of the accidents involving humans are registered. In spite of its prevalence, there are only very few studies on H. lunatus envenomation. The aim of the present study was to analyze the cardiorespiratory alterations caused by H. lunatus envenomation in rodents. Methods Wistar rats injected with H. lunatus scorpion venom were submitted to electrocardiography. After euthanasia, rat lungs were collected and histopathologically analyzed. Mouse cardiomyocytes were used to perform immunofluorescence and calcium transient assays. Data were analyzed by ANOVA or Student’s t-test. The significance level was set at p< 0.05. Results It was... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Hadruroides lunatus venom; Cardiorespiratory alterations; Electrocardiography; Immunofluorescence; Calcium transient. |
| Ano: 2017 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992017000100301 |
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| Andrade,Débora Roque de Freitas; Rezende,Adalgiza Souza Carneiro; Santos,Sandra Aparecida; Nogueira,Márcia Furlan; Santiago,Juliano Martins; Lage,Jéssica; Melo,Marília Martins; Reis,Jenner Karlisson Pimenta; Trigo,Pablo. |
| Abstract: The objective of this work was to evaluate the effects of equine infectious anemia (EIA) on the physical performance of equines from the Brazilian Pantanal region. A total of 16 males were evaluated, divided into two groups: 8 seronegative (G1) and 8 seropositive (G2) for EIA. Two graded exercise tests were carried out before (T1) and after (T2) 42 days of training. Heart rate, lactate concentration, distance covered, and hematocrit level were recorded. In both tests, G1 covered a greater distance. In T2, G2 had lower hematocrit levels and lower speeds reached at different lactate concentrations and heart rates. The athletic performance of the evaluated equines is affected by equine infectious anemia. |
| Tipo: Info:eu-repo/semantics/report |
Palavras-chave: Brazilian breed; Endemic areas; Equideoculture; Equine infectious anemia; Physiology of equine exercise. |
| Ano: 2018 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-204X2018001001184 |
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| Pedroza,Heloisa de Paula; Ferreira,Marina Guimarães; Carvalho,Júlia Gomes de; Melo,Karla Dias Antunes; Keller,Kelly Moura; Melo,Marília Martins; Soto-Blanco,Benito. |
| Nerium oleander é uma planta ornamental responsável por intoxicações em animais e humanos. Todas as partes da planta contém glicosídeos cardiotóxicos, principalmente a oleandrina. Alguns autores apontam que a toxicidade da planta apresentaria variação em função da cor da flor. O objetivo deste trabalho foi determinar se existe variação na concentração de oleandrina nas folhas de N. oleander de exemplares da planta com diferentes cores de inflorescências. Foram coletadas 10 amostras de folhas para cada tipo de flor (branca, rosea e vermelha). Os níveis de oleandrina foram determinados por meio de HPLC-UV após extração com metanol, precipitação com acetato de chumbo e separação em cartucho de C18. A média da concentração obtida em todas as folhas analisadas... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Apocynaceae; Plantas tóxicas; Cardiotoxicidade; Glicosídeos cardíacos; Cardenolídeos. |
| Ano: 2015 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782015000500864 |
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| Telles,Thalita da Costa; Botelho,Ana Flávia Machado; Miranda,Ana Luisa Soares de; Soto-Blanco,Benito; Serakides,Rogéria; Ocarino,Natália de Melo; Melo,Marília Martins. |
| ABSTRACT: The aim of this study was to evaluate the use of mesenchymal stem cells (MSC) in the treatment of myonecrosis induced by Bothrops alternatus venom in rats. Seventy-five male adult Wistar rats were divided into three experimental groups. G1 and G2 were injected in the gastrocnemius muscle with 120μg of B. alternatus venom, while G3 received 200μL of PBS only. Three days after the venom injection, 12 rats from G1 were treated with 5.0 x 106 MSC in PBS, whereas G2 and G3 rats received PBS. Every three days, blood and muscle samples of five animals from each group were taken for serum biochemical and pathological analyses. Histological examinations showed more intense muscle lesions following MSC treatment, characterized by disorganization and loss... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Viperidae envenomation; Stem cells; Rats; Myonecrosis; Muscular repair. |
| Ano: 2018 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782018000300602 |
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| Oliveira,Karen Maciel de; Binda,Nancy Scardua; Lavor,Mário Sérgio Lima; Silva,Carla Maria Osório; Rosado,Isabel Rodrigues; Taguchi,Tatiana Malagoli; Alves,Endrigo Gabellini Leonel; Melo,Marília Martins; Gomez,Marcus Vinícius; Melo,Eliane Gonçalves de. |
| This study aimed to investigate the neuroprotective effect of ω-conotoxin MVIIA (MVIIA) intralesional application in rats submitted to spinal cord injury. Male Wistar rats, weighing 300g±23.4, were distributed in five groups: negative control (SHAM), placebo (PLA), 5μM MVIIA, 10μM MVIIA and 20μM MVIIA MVIIA. After laminectomy of the 12th thoracic vertebra (SHAM), the PLA, 5μM MVIIA, 10μM MVIIA and 20μM MVIIA groups were subjected to acute compressive spinal cord trauma for five minutes, and then five minutes later, the animals received specific treatment in a standard total volume of 2µL, by intralesional route, using sterile PBS as placebo. Locomotor activity was assayed using Basso Beattie Bresnahan (BBB) scale to show the patterning of SCI. With 48... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: MVIIA; Cone snail; Cell viability; Glutamate; Reactive oxygen species; Lipid peroxidation. |
| Ano: 2016 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782016000100150 |
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| Carvalho,Ciro José Sousa de; Melo,Marília Martins; Michell,Ana Flávia Ribeiro Machado; Torres,Bruno Benetti Junta; Riet-Correa,Franklin; Guedes,Roberto Maurício Carvalho; Ferraz,Vany Perpetua; Soto-Blanco,Benito; Silva,Silvana Maria Medeiros de Sousa. |
| ABSTRACT: In Brazil, at least 16 poisonous plant species can affect the central nervous system of livestock. Recently in the state of Piauí, Northeastern Brazil, Brunfelsia uniflora was reported as a cause of nervous signs in donkeys, cattle, and small ruminants. In order to assess the toxicity of B. uniflora extracts, 20 Swiss mice were distributed into four groups (n=5) receiving by gavage alkaloids, flavonoids, saponins, or saline (control group). After administration of the extracts in a single dose (5g kg-1), all mice were observed daily for clinical signs. Mice that received the extracts showed moderate to severe clinical signs, including piloerection, vocalization, and seizures. All mice dosed with saponins died between 10 and 20min after... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Toxicity; Alkaloids; Saponins; Flavonoids; Brunfelsia; Solanaceae. |
| Ano: 2018 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782018000100552 |
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| Telles,Luiz Flávio; Malm,Christina; Melo,Marília Martins; Vilela,Daniel Ambrosio da Rocha; Lago,Luiz Alberto; Silva,Marco Xavier; Martins,Nelson Rodrigo da Silva. |
| Este trabalho avaliou a eficácia dos métodos de enriquecimento ambiental (EA) e da administração do fármaco haloperidol no controle de arrancamento de penas em maritacas mantidas em cativeiro. Foram formados três grupos: G1 tratado com haloperidol, G2 receberam enriquecimento ambiental e G3 aves sem arrancamento de penas. Utilizou-se registro scan, instantâneo dos comportamentos: antes, durante e depois dos tratamentos. Fotografias auxiliaram na avaliação da plumagem através de escore de 0 a 10. No G1, as maritacas reduziram significativamente a atividade física, aumentando o tempo em que ficavam paradas sobre o poleiro e redução também na expressão de outros comportamentos. Nenhuma maritaca do G1 apresentou melhora na qualidade da plumagem, já, no G2,... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Arrancamento de penas haloperidol enriquecimento ambiental Aratinga leucophthalma; Comportamento bem estar animal. |
| Ano: 2015 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782015000601099 |
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| Labarrère,Carla Rosa; Faria,Paulo Mário Carvalho de; Teixeira,Edgar de Alencar; Melo,Marília Martins. |
| Massive production, such as fish growing in water recirculation system, imposes challenges to animals capable of altering their homeostatic balance, and is able to affect their physiological performance. Therefore, the levels of ions and serum enzymes can be used as indicators of fish health. This study aimed to analyze the blood biochemistry profile of hybrid surubim (P. reticulatum X P. corruscans) submitted to different stocking densities in water recirculation system, in two distinct stages of production, from 150 to 400 g (first trial), and 400 to 1000 g (second trial). In the first trial, the five stocking rates were: 27.5, 47.5, 67.5, 87.5 and 107.5 fish/m³ of water. To obtain these densities, it was used 11, 19, 27, 35 and 43 fish per tank,... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Fish; Hybrid; Plasma biochemistry. |
| Ano: 2013 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-70542013000300008 |
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