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A spider derived peptide, PnPP-19, induces central antinociception mediated by opioid and cannabinoid systems J. Venom. Anim. Toxins incl. Trop. Dis.
Pacheco,Daniela da Fonseca; Freitas,Ana Cristina Nogueira; Pimenta,Adriano Monteiro C.; Duarte,Igor Dimitri Gama; Lima,Maria Elena de.
Abstract Background Some peptides purified from the venom of the spider Phoneutria nigriventer have been identified as potential sources of drugs for pain treatment. In this study, we characterized the antinociceptive effect of the peptide PnPP-19 on the central nervous system and investigated the possible involvement of opioid and cannabinoid systems in its action mechanism. Methods Nociceptive threshold to thermal stimulation was measured according to the tail-flick test in Swiss mice. All drugs were administered by the intracerebroventricular route. Results PnPP-19 induced central antinociception in mice in the doses of 0.5 and 1 μg. The non-selective opioid receptor antagonist naloxone (2.5 and 5 μg), μ-opioid receptor antagonist clocinnamox (2...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Peptide PnPP-19; Central antinociception; Phoneutria nigriventer; Μ-opioid receptor; Δ-opioid receptor; CB1 receptor; CB2 receptor.
Ano: 2016 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992016000100325
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