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	Provedor de dados BJPS (2) Autor Gremião,Maria Palmira Daflon (2) Pedreiro,Liliane Neves (2) Carvalho,Flávia Chiva (1) Chaud,Marco Vinícius (1) Cury,Beatriz Stringhetti Ferreira (1) Gonzaga,Edeilson Vitor (1) Lacerda,Gabriel José Silveira (1) Naves,Valéria de Moura Leite (1) Pereira,Gislaine Ribeiro (1) Piantino,Beatriz Lemos (1) Mais... Palavra-chave Chemical cross-linking (1) Chitosan (1) Emulsion method (1) Intestinal permeability. (1) Mesalazine (1) Mucoadhesion (1) P-glycoprotein (1) Polyelectrolyte crosslinking (1) Solid dispersion (1) Zidovudine (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2019 (1) 2016 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Evaluation of polyelectrolyte and emulsion covalent crosslink of chitosan for producing mesalasine loaded submicron particles BJPS Lacerda,Gabriel José Silveira; Piantino,Beatriz Lemos; Gonzaga,Edeilson Vitor; Naves,Valéria de Moura Leite; Pedreiro,Liliane Neves; Gremião,Maria Palmira Daflon; Pereira,Gislaine Ribeiro; Carvalho,Flávia Chiva. This study evaluates various techniques for producing mesalamine (5ASA)-loaded particles employing chitosan as a biopolymer: (1) the polyelectrolyte complexation of chitosan with phthalate hypromelose (HP), (2) the chemical crosslinking of chitosan with genipin and (3) the water-in-oil emulsion method associated with chemical crosslinking with genipin. Systems were characterized by dynamic light scattering, zeta potential (ζ), powder X-ray diffraction (PXRD), Fourier transform infrared spectroscopy (FTIR) and a drug release profile. Method (1) was efficiently produced unloaded nanoparticles (491 nm, PdI=0.26 and ζ = 23.2), but the conditions for chitosan and HP cross-linking enhanced the precipitation of 5ASA. Method (2) caused the degradation of the drug.... Tipo: Info:eu-repo/semantics/article Palavras-chave: Emulsion method; Polyelectrolyte crosslinking; Chemical cross-linking; Chitosan; Mesalazine. Ano: 2019 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502019000100602 A novel approach in mucoadhesive drug delivery system to improve zidovudine intestinal permeability BJPS Pedreiro,Liliane Neves; Cury,Beatriz Stringhetti Ferreira; Chaud,Marco Vinícius; Gremião,Maria Palmira Daflon. ABSTRACT Zidovudine (AZT) mucoadhesive solid dispersions (SD) were prepared using a sodium starch glycolate (SSG) and hypromellose phthalate (HPMCP) mixtures as carrier to enhance the intestinal permeability and bioavailability of zidovudine. SDs were prepared using the co-precipitation method followed by solvent evaporation and characterized according to their physicochemical properties such as particle size, crystallinity, thermal behavior, and liquid uptake ability. In vitro drug dissolution, mucoadhesiveness and AZT intestinal permeability were also determined. Thermal behavior and X-ray diffraction patterns demonstrated the amorphous state of AZT in SD systems. The HPMCP polymer restricted the liquid uptake ability in the acid medium; however, this... Tipo: Info:eu-repo/semantics/article Palavras-chave: Zidovudine; Solid dispersion; Mucoadhesion; P-glycoprotein; Intestinal permeability.. Ano: 2016 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502016000400715 Registros recuperados: 2 Primeira ... 1 ... Última

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